yes, the whole question now hinges around whether the superior results from lab studies translate to human trials in the clinic/hospital. In my younger days this would be called the sixty-four thousand dollar question. Today, it is more like the 6.4 billion dollar question (to be conservative).
In addition to Karin's excellent info in post #15390, take a look at the pictures of the mice in the human xenograft model, if you haven't already. Taken during the Prurisol studies, these mice were engrafted with human psoriatic tissue under the skin:
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