" To assess Kevetrin’s bioavailability, groups o

" To assess Kevetrin’s bioavailability, groups of mice were administered Kevetrin either intravenously or orally. At several different time points, blood samples were taken and then analyzed for concentrations of Kevetrin in the plasma using LC-MS/MS methodology. Results of these analyses demonstrated highly encouraging bioavailability via the oral route. Further studies in a mouse model, in which human ovarian cancer cell line OV90 was examined, showed both intraperitoneal and oral Kevetrin administration were successful in prolonging survival. On the basis of these results, Cellceutix has now selected CROs to perform the additional nonclinical studies, including necessary bridging toxicology, required to support clinical dosing of Kevetrin via the oral route. Additional laboratory research is underway to further expand these findings

https://globenewswire.com/news-release/2016/1...-Drug.html