$ETST Hepatic (liver) endocannabinoid levels are similar to

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$ETST Hepatic (liver) endocannabinoid levels are similar to those in the brain and they are important in the regulation of hepatic hemodynamics, fibrogenesis, as well as lipid metabolism, and in the dysregulation of these functions in liver pathological states. CBD has been shown in vivo to be efficient in treating non-alcoholic fatty liver disease (NAFLD). NAFLD is the most common liver disease throughout the world. Several studies have demonstrated that oxidative stress is a major trigger of the progression of NAFLD to steato-hepatitis (non-alcoholic steato-hepatitis: NASH). NASH leads to exacerbation of inflammatory response and to liver cell dysfunction. A report, published by Allied Market Research, forecasts that the non-alcoholic steato-hepatitis market is expected to garner $1.6 billion by 2020 in North America alone. The high prevalence of Type II diabetes and obesity, which lead to NASH and NAFLD, will sustain that market’s growth. Type II diabetes shares many aspects of NAFLD, and other inflammatory processes in the adipose tissue and liver. Most non-alcoholic fatty liver disease patients are obese and at high risk of developing Type II diabetes. The number of patients living with diabetes worldwide is nearly 400 million and is expected to be more than 500 million by 2030.

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