Portola Pharmaceuticals Announces AndexXa™ (ande
Post# of 301275
SOUTH SAN FRANCISCO, Calif., Nov. 28, 2016 (GLOBE NEWSWIRE) -- Portola Pharmaceuticals (Nasdaq: PTLA ) today announced that clinical and preclinical results from studies of all three of its investigational drugs -- AndexXa™ (andexanet alfa), betrixaban and cerdulatinib -- will be presented at the upcoming 58 th American Society of Hematology (ASH) Annual Meeting and Exposition, which is taking place from December 3-6 at the San Diego Convention Center.
AndexXa, a U.S. Food and Drug Administration (FDA)-designated Breakthrough Therapy, is in development for patients treated with a direct (apixaban, rivaroxaban or edoxaban) or indirect (enoxaparin) Factor Xa inhibitor when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding. Betrixaban, which has Fast Track designation from the FDA, is an oral Factor Xa inhibitor anticoagulant in development for the prevention of venous thromboembolism (VTE) in acute medically ill patients. Cerdulatinib, an oral, dual Syk/JAK kinase inhibitor, is in development to treat patients with resistant or relapsed hematologic cancer.
The abstracts are now available at https://ash.confex.com/ash/2016/webprogram/start.html . Following are details of the oral and poster presentations, which will include additional data not available in the abstracts.
AndexXa™ (andexanet alfa)
- Abstract Title: Reversal of betrixaban-induced anticoagulation in healthy volunteers by andexanet alfa
Publication #: 143 Presenting Author: Mark Crowther, M.D., MSc, FRCPC, Professor, Department of Medicine, Hematology and Thromboembolism and Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario Oral Session Name: 332. Antithrombotic Therapy: Anticoagulation and Bleeding Presentation Date and Time: Saturday, December 3, 1:00 p.m. PT Presentation Location: Room 30
- Abstract Title: Andexanet alfa reverses anticoagulation effects of enoxaparin and associated bleeding in a rabbit acute hemorrhage model
Publication #: 1445 Presenting Author: Pamela B. Conley, Ph.D., Vice President, Biology, Portola Pharmaceuticals Poster Session Name: 332. Antithrombotic Therapy: Poster I Presentation Date and Time: Saturday, December 3, 5:30-7:30 p.m. PT Location: Hall GH
- Abstract Title: Andexanet alfa, a universal antidote under development for Factor Xa inhibitors, reverses rivaroxaban-induced inhibition of thrombin generation initiated by the intrinsic coagulation pathway independent of TFPI
Publication #: 3831 Presenting Author: Genmin Lu, Ph.D., Senior Scientist, Portola Pharmaceuticals Poster Session Name: 332. Antithrombotic Therapy: Poster III Presentation Date and Time: Monday, December 5, 6:00-8:00 p.m. PT Location: Hall GH
Betrixaban
- Abstract Title: The safety and efficacy of full versus reduced dose betrixaban in the Acute Medically Ill VTE (venous thromboembolism) Prevention with Extended Duration Betrixaban (APEX) trial
Publication #: 3824 Presenting Author: Russell Hull, MBBS, University of Calgary, R.A.H. Faculty of Medicine, Alberta, Canada Poster Session Name: 332. Antithrombotic Therapy: Poster III Presentation Date and Time: Monday, December 5, 6:00-8:00 p.m. PT Location: Hall GH
Cerdulatinib
- Abstract Title: Regulation of B-cell receptor signalling by the tumour microenvironment in chronic lymphocytic leukemia (CLL) and its impact on adhesion and miRNA expression
Publication #: 351 Presenting Author: Andrew Steele, Ph.D., Associate Professor, Medicine, University of Southampton, Southampton, UK Oral Session Name: 641. CLL: Biology and Pathophysiology, excluding Therapy: CLL Microenvironment: Cell Intrinsic and Extrinsic Factors Presentation Date and Time: Sunday, December 4, 10:00 a.m. PT Location: Room 5AB
- Abstract Title: Genetic or CD40L-mediated loss of Iκbα is associated with resistance to the dual SYK/JAK inhibitor cerdulatinib in DLBCL cell lines
Publication #: 2768 Presenting Author: Greg Coffey, Ph.D., Senior Scientist II, Portola Pharmaceuticals Poster Session Name: 605. Molecular Pharmacology, Drug Resistance -- Lymphoid and Other Diseases: Poster II Presentation Date and Time: Sunday, December 4, 6:00-8:00 p.m. PT Location: Hall GH
About Portola Pharmaceuticals, Inc. Portola Pharmaceuticals is a biopharmaceutical company developing product candidates that could significantly advance the fields of thrombosis and other hematologic diseases. The Company is advancing three programs, including betrixaban, an oral, once-daily Factor Xa inhibitor; AndexXa™ (andexanet alfa), a recombinant protein designed to reverse the anticoagulant effect in patients treated with an oral or injectable Factor Xa inhibitor; and cerdulatinib, a Syk/JAK inhibitor in development to treat hematologic cancers. Portola's partnered program is focused on developing selective Syk inhibitors for inflammatory conditions. For more information, visit www.portola.com and follow the Company on Twitter @Portola_Pharma.
Investor Contact: Ana Kapor Portola Pharmaceuticals ir@portola.com Media Contact: Julie Normart W2O Group jnormart@w2ogroup.com 415.946.1087
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