leads to the belief that serious price action may

>>leads to the belief that serious price action may precede establishment of MTD?

If the data is released before the round where MTD is reached. This is a rapid trial. The usual time is 18 months to two years. This will be done in 6 months. That's just more confirmation of what everyone, including the FDA, expects to see.

Yes, even with 3 species, there are surprises once humans enter the picture. But, the species Nude Mice mimic the expected reaction in humans very closely. They tolerated high doses very well, as in no observed adverse effects. The other two species only showed the outcome range.