Director/PDMR Shareholding 26 September 2016 16:00

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Director/PDMR Shareholding

26 September 2016 16:00 Transaction by Person Discharging Managerial Responsibilities Disclosure Rule DTR 3.1.4 On 26 September 2016, the interest of Sean Bohen, a person discharging managerial responsibilities, in the ordinary shares of AstraZeneca PLC changed as detailed below. The change in interest relates to the vesting of an award of AstraZeneca American Depositary Shares (ADSs) made in September 2015 under the AstraZeneca Restricted Share Plan. One ordinary share equals two ADSs. After sufficient vested shares were withheld to satisfy certain tax obligations arising on the vesting, Mr Bohen has become beneficially entitled to and has received 12,385 ADSs into a personal brokerage account. For tax purposes, the fair market value of the shares at vest was $33.97 per ADS being the closing price on the last trading day preceding the vesting day. The attached notification, made in accordance with the requirements of the EU Market Abuse Regulation, gives further detail. Notification and public disclosure of transactions by persons discharging managerial responsibilities and persons closely associated with them 1 Details of the person discharging managerial responsibilities / person closely associated a) Name Sean Bohen 2 Reason for the notification a) Position/status Executive Vice -President, Global Medicines Development and Chief Medical Officer b) Initial notification /Amendment Initial notification 3 Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor a) Name AstraZeneca PLC b) LEI Not applicable 4 Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted a) Description of the financial AstraZeneca instrument, type of instrument PLC American Identification code Depositary Shares CUSIP: 046353108 b) Nature of the transaction Acquisition of AstraZeneca American Depositary Shares pursuant to the vesting of an award under the AstraZeneca Restricted Share Plan c) Price(s) and volume(s)  Price(s)       Volume(s)         12,385 $33.97 d) Aggregated information - Aggregated Not volume - Price applicable - single transaction e) Date of the transaction 26 September 2016 f) Place of the transaction New York About AstraZeneca AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of diseases in three therapy areas - Respiratory and Autoimmunity, Cardiovascular and Metabolic Diseases, and Oncology. The Company is also active in inflammation, infection and neuroscience through numerous collaborations. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information please visit: www.astrazeneca.com CONTACTS Media Enquiries Neil Burrows UK/Global +44 203 749 5637 Vanessa Rhodes UK/Global +44 203 749 5736 Karen Birmingham UK/Global +44 203 749 5634 Rob Skelding UK/Global +44 203 749 5821 Jacob Lund Sweden +46 8 553 260 20 Michele Meixell US +1 302 885 2677 Investor Relations UK Thomas Kudsk Larsen +44 203 749 5712 Craig Marks Finance, Fixed Income, M&A +44 7881 615 764 Nick Stone Respiratory & Autoimmunity +44 203 749 5716 Henry Wheeler Oncology +44 203 749 5797 Christer Gruvris Infection & Neuroscience +44 203 749 5711 US Lindsey Trickett Cardiovascular & Metabolic Diseases +1 240 543 7970 Mitchell Chan  Oncology +1 240 477 3771 Toll-free +1 866 381 7277 Adrian Kemp Company Secretary AstraZeneca PLC -ENDS-

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