Director Declaration 22 September 2016 11.00 New external

22 September 2016 11.00 New external board appointment Listing Rule LR 9.6.14 R (2) Ann Cairns, a Non-Executive Director of AstraZeneca PLC, is expected to join the Board of Directors of Intercontinental Exchange, Inc., a company listed on the New York Stock Exchange, effective from 2017. About AstraZeneca AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of diseases in three therapy areas - Respiratory and Autoimmunity, Cardiovascular and Metabolic Diseases, and Oncology. The Company is also active in inflammation, infection and neuroscience through numerous collaborations. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information please visit: www.astrazeneca.com CONTACTS Media Enquiries Neil Burrows UK/Global +44 203 749 5637 Vanessa Rhodes UK/Global +44 203 749 5736 Karen Birmingham UK/Global +44 203 749 5634 Rob Skelding UK/Global +44 203 749 5821 Jacob Lund Sweden +46 8 553 260 20 Michele Meixell US +1 302 885 2677 Investor Relations UK Thomas Kudsk Larsen +44 203 749 5712 Craig Marks Finance, Fixed Income, M&A +44 7881 615 764 Nick Stone Respiratory & Autoimmunity +44 203 749 5716 Henry Wheeler Oncology +44 203 749 5797 Christer Gruvris Infection & Neuroscience +44 203 749 5711 US Lindsey Trickett Cardiovascular & Metabolic Diseases +1 240 543 7970 Mitchell Chan  Oncology +1 240 477 3771 Toll-free +1 866 381 7277 Adrian Kemp Company Secretary AstraZeneca PLC -ENDS-