De-activating the Ticking Bomb of Brain Diseases w

De-activating the Ticking Bomb of Brain Diseases with Nanomedicines

Strong efficacy and excellent safety have been demonstrated with no evidence of central nervous system (CNS) toxicity or immunogenicity, even after repeat dosing of up to 22 cycles

Nanomedicines are the only technologies today that have shown significant promise in brain delivery without comprising the integrity of the BBB in preclinical and early clinical phase trials . The size of the particles is a crucial parameter. Particles less than 70 nm have shown higher percentages of dose levels in the brain compared to larger particles when they are not functionalized with peptides or proteins for endocytosis across the BBB (3).

Nanoparticles conjugated with ligands able to interact with BBB receptors at a relatively low density (low avidity) have the best performance.

http://www.pharmtech.com/de-activating-tickin...omedicines


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