One E-Commerce Corp (ISLT) 0.0500 $ISLT
Clinical Study Includes Islet Sciences MDNA Diagnostic for Early Detection of Insulin Dependent Diabetes
ACCESSWIRE - Fri May 20, 7:30AM CDT
Study Supported by NIH Funding
Islet Sciences Appoints Dr. Gary Blackburn, Senior Pharma and Diagnostics Executive at Roche, Genmark, Motorola, and other Global Healthcare Enterprises, to the Board of Directors
ACCESSWIRE - Mon Apr 18, 1:15PM CDT
NEW YORK, NY / ACCESSWIRE / April 18, 2016 / Islet Sciences, Inc. (OTC: ISLT) ("Islet Sciences"
, a biopharmaceutical company focused on developing new technologies and medicines for the early detection, intervention and pre-treatment to prevent and slow the progression of metabolic disease, today announced that Dr. Gary Blackburn has been appointed to the Board of Directors, effective immediately.
Islet Sciences Announces the Appointment of Christian W. Mende, M.D. as Chief Scientific Officer
ACCESSWIRE - Wed Mar 23, 7:01AM CDT
NEW YORK, NY / ACCESSWIRE / March 23, 2016 / Islet Sciences, Inc. (OTC: ISLT) ("Islet Sciences" , a biopharmaceutical company focused on developing new technologies and medicines for the early detection, intervention, and pre-treatment to prevent and slow the progression of metabolic disease, today announced that Christian W. Mende, M.D., has joined the Company as Chief Scientific Officer.
Diabetic Retinopathy - Pipeline Review, H2 2015
M2 - Thu Dec 17, 2:54AM CST
Research and Markets (http://www.researchandmarkets.com/research/kr3mll/diabetic) has announced the addition of the "Diabetic Retinopathy - Pipeline Review, H2 2015" report to their offering. The report provides an overview of the Diabetic Retinopathy's therapeutic pipeline. The report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Reasons to Buy: - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Diabetic Retinopathy - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Diabetic Retinopathy pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline Companies Include: - Acucela Inc. - Aerpio Therapeutics, Inc. - Angstrom Pharmaceuticals, Inc. - Antisense Therapeutics Limited - BCN Peptides, S.A. - BioDiem Ltd - Biomar Microbial Technologies - Charlesson LLC. - Crinetics Pharmaceuticals, Inc. - Dimerix Bioscience Pty Ltd - Dynamis Therapeutics, Inc. - EyeGene, Inc. - Foresee Pharmaceuticals, LLC - GTx, Inc. - Icon Bioscience, Inc. - IMMD Inc. - Islet Sciences, Inc. - Kowa Company, Ltd. - LegoChem Biosciences, Inc - Lpath, Inc. - Others (20) For more information visit http://www.researchandmarkets.com/research/kr3mll/diabetic
GTXI: 0.59 (+0.01), LPTN: 2.75 (-0.07)
Global Non-Alcoholic SteatoHepatitis (NASH) Analysis 2015 - Disease Prevalence, Drugs in Development, Regulatory Guidelines and Market Opportunities
M2 - Fri Dec 11, 9:09AM CST
Research and Markets (http://www.researchandmarkets.com/research/m95wfc/nonalcoholic) has announced the addition of the "Non-Alcoholic SteatoHepatitis (NASH): An Analysis of Disease Prevalence, Drugs in Development, Regulatory Guidelines and Market Opportunity in Various Geographies" report to their offering. Sales of Hepatitis C drugs crossed -$10bn in 2014 proving that treatments for liver disease could become mega-blockbusters and Non-Alcoholic SteatoHepatitis (NASH) is expected to be equally lucrative. Improved diagnosis rate and change in treatment guidelines along with defined clinical trials endpoint are the concerns for the emerging therapy. US FDA is expected to release guidelines for the clinical trial in CY16 and this should accelerate the development of the drugs targeting NASH. NASH is the progressive form of Non-Alcoholic Fatty Liver Disease - NAFLD. While NASH can reverse itself, in many cases, the resulting liver scarring causes a patient's liver to harden and failure to work properly. It is estimated that NASH affects 2 to 5% of the US population. Other developed countries such as Europe and Japan also have similar or higher incidence of NASH disease. Due to the varying physical and metabolism traits across various geographies, development of drugs for NASH is facing difficulty. In Japan, the prevalence of NASH is rising although the population is not typically overweight. Countries like India and China with bigger population and changes in lifestyles face a greater risk of NASH along with other lifestyle diseases like Diabetes and Cardiovascular related complexities. As per the US Association of Liver Disease, of those who develop NASH, -15-25% will progress to end stage liver disease (ESLD) and hepatocellular carcinoma (HCC) over 10-20 years. Today, 1/3rd of Liver transplants and HCC are caused by NASH and the total cost burden of this on US is over -$5 billion per year. Only new treatments in NASH could lead to a cut in this major cost burden along with improving quality of life. Since a new innovation in NASH has been enlightened, the interest in companies developing drugs for NASH has also gone up. In Jan. 2015, Gilead Sciences (GILD) acquired Phenex Pharma's Farnesoid X Receptor (FXR) program comprising small molecule FXR agonists for the treatment of liver diseases including nonalcoholic steatohepatitis (NASH) and other Liver Diseases. Merck-NGM Biopharma and Boehringer Ingelheim - Pharmaxis also entered into an exclusive agreement for the pipeline products which are being developed for NASH with a potential deal value of -$450-600mn. This report will provide detailed analysis on NASH disease and Drugs in development in broader pharma market. This report list all the drugs in clinical trial and their design and the population recruited, also tells about the pathways representing possible targets for the treatment of NASH. Key Topics Covered: 1. Executive Summary 2. Overview of NASH 2.1 Possible targets for the treatment of NASH 2.2 Drugs in the pipeline 2.3 Key Milestones 2.4 Drivers of M&A/ Licensing deals in NASH 2.5 NASH disease market opportunity to 2025 3. Products in Development and Competitive Landscape 3.1 Key Drugs/Companies Developing Drugs Against NASH 3.1.1 Obeticholic Acid - Intercept Pharmaceuticals/ Dainippon Sumitomo 3.1.2 Elafibranor - Genfit 3.1.3 Multiple programs - Gilead 3.1.4 Emricasan - Conatus Pharmaceuticals 3.1.5 Aramchol - Galmed Pharmaceuticals 3.1.6 Cenicriviroc - Tobira Therapeutics 3.1.7 IMM-124E - Immuron 3.1.8 GR-MD-02 - Galectin Therapeutics 3.1.9 TD139 - Galecto Biotech 3.1.10 SHP626 - Shire 3.1.11 PXS4728A - Boehringer Ingelheim 3.2 Repurposed Drugs for NASH 3.2.1 Remogliflozin etabonate - Islet Sciences/BHV pharma 3.2.2 Lipaglyn (saroglitazar) - Cadila Healthcare 3.2.3 Victoza (liraglutide) - Novo Nordisk 4. NASH - Etiology, Pathogenesis, Diagnosis and Current Treatment 4.1 Cause, Symptoms, Pathogenesis, Diagnosis 4.2 Current treatment including Herbal Medicine 5. Regulatory Pathway 5.1 Challenges in trials using endpoints to define clinically meaningful benefits 5.2 Potential Clinical Trial Design for NASH and Endpoints 6. Annexure Companies Mentioned - Boehringer Ingelheim - Cadila Healthcare - Conatus Pharmaceuticals - Galectin Therapeutics - Galecto Biotech - Galmed Pharmaceuticals - Genfit - Gilead - Immuron, - Intercept Pharmaceuticals/ Dainippon Sumitomo - Islet Sciences/BHV pharma - Novo Nordisk - Shire - Tobira Therapeutics For more information visit http://www.researchandmarkets.com/research/m9...nalcoholic
NVO: 46.89 (+0.04), GLMD: 3.78 (+0.08), GILD: 79.77 (-0.31), MRK: 62.85 (+0.53), CNAT: 1.90 (-0.04), GALT: 1.62 (-0.15), ICPT: 154.96 (+1.32), TBRA: 4.86 (+0.09)
Nonalcoholic Steatohepatitis (NASH) Commercial Opportunities - Pipeline Analysis & Forecast Report
M2 - Mon Dec 07, 8:47AM CST
Research and Markets (http://www.researchandmarkets.com/research/p3853f/nonalcoholic) has announced the addition of the "Nonalcoholic steatohepatitis (NASH) - Pipeline Analysis" report to their offering. NASH Facts: - 10% of the adult population in U.S has NASH - NASH can occur in all age groups and even in children but mostly it is diagnosed in the patients between the age of 40-60 - NASH affects between 9.5-16 million people in United States accounting for 3 to 5 % of the population - NASH is a third leading and rapidly increasing indication for liver transplants accounting for 10% of liver transplants in U.S. - In America, the obesity rate has doubled in adults and tripled in children in the past 10 years which would impact the prevalence of NASH in the coming years, being one of the major risk factors for NASH - NASH has the potential to become one of the leading cause of end stage liver disease, liver transplantation, and hepatocellular carcinoma in the next decades This report enables Pharmaceutical/Biotech companies, Academic institutes, Individual researchers, Investors, Medical technology companies, Service providers and other associated stake holders to identify and analyze the available licensing/collaborative commercial opportunities in the Nonalcoholic steatohepatitis (NASH) Drug market. The report also provides strategic insights on medicines that are likely to have an impact on future NASH treatment space. As some of the candidates are nearing key R&D milestones, there is a huge competition among large pharmaceutical and biotech companies to acquire these assets. Gilead's acquisition of Phenex FXR program & Boehringer's acquisition of NASH clinical asset from Pharmaxis supports this trend. Diagnosis of NASH still requires histological confirmation and there is a great demand for specific non-invasive diagnosis for distinguishing NASH from other liver diseases. Therefore, there is a need to develop better diagnostic and therapeutic strategies for patients with NASH. There is a tremendous opportunity for upcoming therapies specific to NASH such as MAbs, RNA-based therapies & Recombinant proteins. These modalities may provide Anti-fibrosis, Anti-inflammatory and metabolic benefits. Companies Mentioned: - Boehringer Ingelheim - Cerenis Therapeutics - Connexios Life Sciences - Genfit - Gilead Sciences - Intercept - Islet Sciences - Nimbus Therapeutics - Verva Pharmaceuticals - Viking Therapeutics Report Structure: 1. Report Description 2. Introduction 3. Hot Targets, Mechanisms & Therapies 4. Market Data 5. Pipeline Analysis 6. Small Molecules 7. Large Molecule 8. RNA-based Therapy 9. Recombinant Proteins 10. Antibodies 11. Large Molecules (Unspecified) 12. Other Molecules 13. NASH Drug Analysis based on Mechanisms 14. Major Players 15. References For more information visit http://www.researchandmarkets.com/research/p3...nalcoholic
GILD: 79.77 (-0.31), VKTX: 1.39 (+0.08)
Islet Sciences Appoints Chief Financial and Chief Operating Officer
ACCESSWIRE - Wed Oct 21, 3:05PM CDT
Seasoned Financial Executive, David E. Wilder, Joins Biopharmaceutical Company
Former American Diabetes Association Executive Chairman and Eli Lilly Executive Joins Islet Sciences as Chairman, President and CEO
ACCESSWIRE - Thu Oct 01, 3:54PM CDT
Larry K. Ellingson, Proven Pharmacy Executive, Adds Significant Diabetes and Public Company Expertise
Diabetic Retinopathy Therapeutics Pipeline Review, H1 2015 - 34 Companies & 50 Drug Profiles
M2 - Tue Jul 21, 3:44AM CDT
Research and Markets (http://www.researchandmarkets.com/research/7fgxcs/diabetic) has announced the addition of the "Diabetic Retinopathy - Pipeline Review, H1 2015" report to their offering. This report provides comprehensive information on the therapeutic development for Diabetic Retinopathy, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Diabetic Retinopathy and special features on late-stage and discontinued projects. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Companies Involved in Therapeutics Development - Acucela Inc. - Aerpio Therapeutics, Inc. - Angstrom Pharmaceuticals, Inc. - Antisense Therapeutics Limited - Aprogen, Inc. - BioDiem Ltd - Biomar Microbial Technologies - Charlesson LLC. - Crinetics Pharmaceuticals, Inc. - Dimerix Bioscience Pty Ltd - EyeGene, Inc. - Foresee Pharmaceuticals, LLC - GTx, Inc. - Icon Bioscience, Inc. - IMMD Inc. - Islet Sciences, Inc. - Kowa Company, Ltd. - LegoChem Biosciences, Inc - MacuCLEAR, Inc. - MingSight Pharmaceuticals - Molecular Design International, Inc. - OcuCure Therapeutics, Inc. - Ohr Pharmaceutical Inc. - PanOptica, Inc. - Promedior, Inc. - R-Tech Ueno, Ltd. - Resolvyx Pharmaceuticals, Inc - RestorGenex Corporation - Sirnaomics, Inc. - Stelic Institute & Co. - Stemedica Cell Technologies, Inc. - Targazyme, Inc. - ThromboGenics NV - TWi Pharmaceuticals, Inc. Drug Profiles - 49-B - A-6 - A-717 - AC-301 - AKB-9778 - ALG-1001 - AP-202 - ATL-1103 - BDM-E - Beta-LGND2 - CLT-01001 - CLT-01007 - CLT-01012 - cyclosporine - Cyndacel-M - DG-3173 - DMX-200 - Drug to Activate EGF-Like-Domain Multiple 7 for Oncology and Diabetic Retinopathy - DT-23552 - E-1086 - EG-Mirotin - emixustat hydrochloride - FP-008 - IB-09A0133 - IMD-0354 - JP-153 - L-779976 - LCB-030110 For more information visit http://www.researchandmarkets.com/research/7fgxcs/diabetic
GTXI: 0.59 (+0.01), OHRP: 2.73 (+0.04)
Nonalcoholic steatohepatitis (NASH) - 2015 Pipeline Analysis
M2 - Tue Jul 21, 3:00AM CDT
Research and Markets (http://www.researchandmarkets.com/research/kf56cl/nonalcoholic) has announced the addition of the "Nonalcoholic steatohepatitis (NASH) - Pipeline Analysis" report to their offering. This report gives comprehensive insight on the various drugs being developed for the treatment of NASH. The report covers all the drugs being developed in various phases (Discovery, Preclinical & Clinical development). The pipeline focuses on novel medicines covering small molecules, monoclonal antibodies, Recombinant proteins and RNA-based therapeutics, but excludes Off-label, symptom relief drugs, generic combinations. The report also covers hot targets in research for NASH treatments and disease progression biomarkers. This report enables Pharmaceutical/Biotech companies, Academic institutes, Individual researchers, Investors, Medical technology companies, Service providers and other associated stake holders to identify and analyze the available licensing/collaborative commercial opportunities in the Nonalcoholic steatohepatitis (NASH) Drug market. The report also provides strategic insights on medicines that are likely to have an impact on future NASH treatment space. NASH is associated with fatty liver, hepatic inflammation, hepatocyte injury and fibrogenesis and may worsen into fibrosis or cirrhosis, liver failure and rarely into liver cancer. Currently, there are no approved drugs for NASH by U.S. Food and Drug Administration (FDA) and there a high unmet clinical need. NASH, if untreated can progress to liver-destroying cirrhosis and potentially cancer. Majority of the NASH pipeline drugs are from specialised small to mid pharmaceutical & biotech companies. As some of the candidates are nearing key R&D milestones, there is a huge competition among large pharmaceutical and biotech companies to acquire these assets. Gilead's acquisition of Phenex FXR program & Boehringer's acquisition of NASH clinical asset from Pharmaxis supports this trend. Diagnosis of NASH still requires histological confirmation and there is a great demand for specific non-invasive diagnosis for distinguishing NASH from other liver diseases. Therefore, there is a need to develop better diagnostic and therapeutic strategies for patients with NASH. There is a tremendous opportunity for upcoming therapies specific to NASH such as MAbs, RNA-based therapies & Recombinant proteins. These modalities may provide Anti-fibrosis, Anti-inflammatory and metabolic benefits. Key Topics Covered: 1. Report Description 2. Introduction 3. Hot Targets, Mechanisms & Therapies 4. Market Data 5. Pipeline Analysis 6. Small Molecules 7. Large Molecule 8. RNA-based Therapy 9. Recombinant Proteins 10. Antibodies 11. Large Molecules (Unspecified) 12. Other Molecules 13. NASH Drug Analysis based on Mechanisms 14. Major Players - Boehringer Ingelheim - Cerenis Therapeutics - Connexios Life Sciences - Genfit - Gilead Sciences - Intercept - Islet Sciences - Nimbus Therapeutics - Verva Pharmaceuticals - Viking Therapeutics For more information visit http://www.researchandmarkets.com/research/kf...nalcoholic
GILD: 79.77 (-0.31), VKTX: 1.39 (+0.08)
Global Diabetic Nephropathy Pipeline Review, H1 2015
M2 - Tue Jun 02, 7:58AM CDT
Research and Markets (http://www.researchandmarkets.com/research/frxw7k/diabetic) has announced the addition of the "Diabetic Nephropathy - Pipeline Review, H1 2015" report to their offering. This report provides comprehensive information on the therapeutic development for Diabetic Nephropathy, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Diabetic Nephropathy and special features on late-stage and discontinued projects. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Companies Involved in Therapeutics Development - AbbVie Inc. - Aerpio Therapeutics, Inc. - Antisense Therapeutics Limited - Astellas Pharma Inc. - AstraZeneca PLC - Bayer AG - Bristol-Myers Squibb Company - Cellmid Limited - ChemoCentryx, Inc. - Concert Pharmaceuticals, Inc. - CTI BioPharma Corp. - Daiichi Sankyo Company, Limited - DiaMedica Inc. - Dimerix Bioscience Pty Ltd - Dong Wha Pharma Co., Ltd. - Eli Lilly and Company - Galectin Therapeutics, Inc. - GenKyoTex S.A. - Gentium S.p.A. - Gilead Sciences, Inc. - GlaxoSmithKline plc - Glucox Biotech AB - GNI Group Ltd. - IMMD Inc. - Intercept Pharmaceuticals, Inc. - InterMune, Inc. - Inventiva SAS - Islet Sciences, Inc. - Jenrin Discovery, Inc. - Johnson & Johnson - Mallinckrodt plc - Mesoblast Limited - Mitsubishi Tanabe Pharma Corporation - NephroGenex, Inc. - Noxxon Pharma AG For more information visit http://www.researchandmarkets.com/research/frxw7k/diabetic
NRX: 0.14 (+0.01), GALT: 1.62 (-0.15), LLY: 78.24 (+0.23), GSK: 43.55 (-0.19), BMY: 58.77 (+0.01), CTIC: 0.35 (+0.01), CNCE: 10.14 (-0.49), JNJ: 119.04 (+0.47), GILD: 79.77 (-0.31), AZN: 33.05 (-0.18), CCXI: 5.00 (+0.16), ICPT: 154.96 (+1.32), ABBV: 64.61 (-0.11)
Islet Sciences, Inc. Publishes Data Supporting Remogliflozin Etabonate as a Potential Treatment for NAFLD and NASH
GlobeNewswire - Mon May 04, 6:47AM CDT
Islet Sciences, Inc. (OTCQB:ISLT), a biopharmaceutical company developing new medicines and technologies for the treatment and diagnosis of metabolic disease, has announced publication of pre-clinical data that demonstrates remogliflozin etabonate has significant potential as a novel therapeutic for the treatment of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).
Islet Sciences, Inc. Presented at 50th International Liver Conference
GlobeNewswire - Thu Apr 23, 11:02AM CDT
Islet Sciences, Inc. (OTCQB:ISLT), a biopharmaceutical company developing new medicines and technologies for the treatment of metabolic disease, announced today that Chief Operating Officer, Dr. William Wilkison presented "Remogliflozin Etabonate Reduces Insulin Resistance and Liver Function Enzymes: Role for Treatment of NASH" at the 50th International Liver Conference hosted by the European Association for the Study of Liver (EASL) in Vienna, Austria.
Islet Holdings, Inc. Continues With Pursuing Damages in Federal Court
GlobeNewswire - Thu Mar 26, 7:11AM CDT
Islet Holdings, Inc. (OTC:ISHI) ("the Company" previously announced that in August 2012, the Company and its subsidiary filed a complaint in Federal District Court for the District of Utah against Islet Sciences, Inc., a publicly-held company trading under the symbol "ISLT", and several individuals intimately involved with Islet Sciences. The complaint is related to the Company's prior work and development in the type 1 diabetes treatment industry.
Islet Sciences, Inc. COO to Present at Metabolic Leaders Forum
GlobeNewswire - Tue Mar 24, 6:55AM CDT
Islet Sciences, Inc. (OTCQB:ISLT), a biopharmaceutical company developing new medicines and technologies for the treatment of metabolic disease, announced today that Chief Operating Officer, Dr. William Wilkison, will present data on remogliflozin etabonate and its efficacy and safety in the treatment of type 2 diabetes and NAFLD/NASH as well as participating in a panel discussion at the Metabolic Leaders Forum 2015 in Boston, MA on March 24th.
Islet Sciences, Inc. COO to Present at EASL: Remogliflozin Etabonate as Novel Treatment for Non-alcoholic Steatohepatitis (NASH)
GlobeNewswire - Mon Mar 09, 7:07AM CDT
Islet Sciences, Inc. (OTCQB:ISLT), a biopharmaceutical company developing new medicines and technologies for the treatment of metabolic disease, announced today that Chief Operating Officer, Dr. William Wilkison, was invited to present clinical and preclinical data highlighting the unique properties of selective sodium glucose transporter 2 (SGLT2) inhibitor, remogliflozin etabonate, as a novel treatment for non-alcoholic steatohepatitis (NASH) and its precursor, non-alcoholic fatty liver disease (NAFLD). The data will be presented at the 50th International Liver Conference held in Vienna, Austria April 22 - 26, 2015 by the European Association for the Study of Liver (EASL).
Clinical Study Includes Islet Sciences MDNA Diagnostic for Early Detection of Insulin Dependent Diabetes
ACCESSWIRE - Fri May 20, 7:30AM CDT
Study Supported by NIH Funding
Islet Sciences Appoints Dr. Gary Blackburn, Senior Pharma and Diagnostics Executive at Roche, Genmark, Motorola, and other Global Healthcare Enterprises, to the Board of Directors
ACCESSWIRE - Mon Apr 18, 1:15PM CDT
NEW YORK, NY / ACCESSWIRE / April 18, 2016 / Islet Sciences, Inc. (OTC: ISLT) ("Islet Sciences"
, a biopharmaceutical company focused on developing new technologies and medicines for the early detection, intervention and pre-treatment to prevent and slow the progression of metabolic disease, today announced that Dr. Gary Blackburn has been appointed to the Board of Directors, effective immediately. Islet Sciences Announces the Appointment of Christian W. Mende, M.D. as Chief Scientific Officer
ACCESSWIRE - Wed Mar 23, 7:01AM CDT
NEW YORK, NY / ACCESSWIRE / March 23, 2016 / Islet Sciences, Inc. (OTC: ISLT) ("Islet Sciences"
, a biopharmaceutical company focused on developing new technologies and medicines for the early detection, intervention, and pre-treatment to prevent and slow the progression of metabolic disease, today announced that Christian W. Mende, M.D., has joined the Company as Chief Scientific Officer. Diabetic Retinopathy - Pipeline Review, H2 2015
M2 - Thu Dec 17, 2:54AM CST
Research and Markets (http://www.researchandmarkets.com/research/kr3mll/diabetic) has announced the addition of the "Diabetic Retinopathy - Pipeline Review, H2 2015" report to their offering. The report provides an overview of the Diabetic Retinopathy's therapeutic pipeline. The report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Reasons to Buy: - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Diabetic Retinopathy - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Diabetic Retinopathy pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline Companies Include: - Acucela Inc. - Aerpio Therapeutics, Inc. - Angstrom Pharmaceuticals, Inc. - Antisense Therapeutics Limited - BCN Peptides, S.A. - BioDiem Ltd - Biomar Microbial Technologies - Charlesson LLC. - Crinetics Pharmaceuticals, Inc. - Dimerix Bioscience Pty Ltd - Dynamis Therapeutics, Inc. - EyeGene, Inc. - Foresee Pharmaceuticals, LLC - GTx, Inc. - Icon Bioscience, Inc. - IMMD Inc. - Islet Sciences, Inc. - Kowa Company, Ltd. - LegoChem Biosciences, Inc - Lpath, Inc. - Others (20) For more information visit http://www.researchandmarkets.com/research/kr3mll/diabetic
GTXI: 0.59 (+0.01), LPTN: 2.75 (-0.07)
Global Non-Alcoholic SteatoHepatitis (NASH) Analysis 2015 - Disease Prevalence, Drugs in Development, Regulatory Guidelines and Market Opportunities
M2 - Fri Dec 11, 9:09AM CST
Research and Markets (http://www.researchandmarkets.com/research/m95wfc/nonalcoholic) has announced the addition of the "Non-Alcoholic SteatoHepatitis (NASH): An Analysis of Disease Prevalence, Drugs in Development, Regulatory Guidelines and Market Opportunity in Various Geographies" report to their offering. Sales of Hepatitis C drugs crossed -$10bn in 2014 proving that treatments for liver disease could become mega-blockbusters and Non-Alcoholic SteatoHepatitis (NASH) is expected to be equally lucrative. Improved diagnosis rate and change in treatment guidelines along with defined clinical trials endpoint are the concerns for the emerging therapy. US FDA is expected to release guidelines for the clinical trial in CY16 and this should accelerate the development of the drugs targeting NASH. NASH is the progressive form of Non-Alcoholic Fatty Liver Disease - NAFLD. While NASH can reverse itself, in many cases, the resulting liver scarring causes a patient's liver to harden and failure to work properly. It is estimated that NASH affects 2 to 5% of the US population. Other developed countries such as Europe and Japan also have similar or higher incidence of NASH disease. Due to the varying physical and metabolism traits across various geographies, development of drugs for NASH is facing difficulty. In Japan, the prevalence of NASH is rising although the population is not typically overweight. Countries like India and China with bigger population and changes in lifestyles face a greater risk of NASH along with other lifestyle diseases like Diabetes and Cardiovascular related complexities. As per the US Association of Liver Disease, of those who develop NASH, -15-25% will progress to end stage liver disease (ESLD) and hepatocellular carcinoma (HCC) over 10-20 years. Today, 1/3rd of Liver transplants and HCC are caused by NASH and the total cost burden of this on US is over -$5 billion per year. Only new treatments in NASH could lead to a cut in this major cost burden along with improving quality of life. Since a new innovation in NASH has been enlightened, the interest in companies developing drugs for NASH has also gone up. In Jan. 2015, Gilead Sciences (GILD) acquired Phenex Pharma's Farnesoid X Receptor (FXR) program comprising small molecule FXR agonists for the treatment of liver diseases including nonalcoholic steatohepatitis (NASH) and other Liver Diseases. Merck-NGM Biopharma and Boehringer Ingelheim - Pharmaxis also entered into an exclusive agreement for the pipeline products which are being developed for NASH with a potential deal value of -$450-600mn. This report will provide detailed analysis on NASH disease and Drugs in development in broader pharma market. This report list all the drugs in clinical trial and their design and the population recruited, also tells about the pathways representing possible targets for the treatment of NASH. Key Topics Covered: 1. Executive Summary 2. Overview of NASH 2.1 Possible targets for the treatment of NASH 2.2 Drugs in the pipeline 2.3 Key Milestones 2.4 Drivers of M&A/ Licensing deals in NASH 2.5 NASH disease market opportunity to 2025 3. Products in Development and Competitive Landscape 3.1 Key Drugs/Companies Developing Drugs Against NASH 3.1.1 Obeticholic Acid - Intercept Pharmaceuticals/ Dainippon Sumitomo 3.1.2 Elafibranor - Genfit 3.1.3 Multiple programs - Gilead 3.1.4 Emricasan - Conatus Pharmaceuticals 3.1.5 Aramchol - Galmed Pharmaceuticals 3.1.6 Cenicriviroc - Tobira Therapeutics 3.1.7 IMM-124E - Immuron 3.1.8 GR-MD-02 - Galectin Therapeutics 3.1.9 TD139 - Galecto Biotech 3.1.10 SHP626 - Shire 3.1.11 PXS4728A - Boehringer Ingelheim 3.2 Repurposed Drugs for NASH 3.2.1 Remogliflozin etabonate - Islet Sciences/BHV pharma 3.2.2 Lipaglyn (saroglitazar) - Cadila Healthcare 3.2.3 Victoza (liraglutide) - Novo Nordisk 4. NASH - Etiology, Pathogenesis, Diagnosis and Current Treatment 4.1 Cause, Symptoms, Pathogenesis, Diagnosis 4.2 Current treatment including Herbal Medicine 5. Regulatory Pathway 5.1 Challenges in trials using endpoints to define clinically meaningful benefits 5.2 Potential Clinical Trial Design for NASH and Endpoints 6. Annexure Companies Mentioned - Boehringer Ingelheim - Cadila Healthcare - Conatus Pharmaceuticals - Galectin Therapeutics - Galecto Biotech - Galmed Pharmaceuticals - Genfit - Gilead - Immuron, - Intercept Pharmaceuticals/ Dainippon Sumitomo - Islet Sciences/BHV pharma - Novo Nordisk - Shire - Tobira Therapeutics For more information visit http://www.researchandmarkets.com/research/m9...nalcoholic
NVO: 46.89 (+0.04), GLMD: 3.78 (+0.08), GILD: 79.77 (-0.31), MRK: 62.85 (+0.53), CNAT: 1.90 (-0.04), GALT: 1.62 (-0.15), ICPT: 154.96 (+1.32), TBRA: 4.86 (+0.09)
Nonalcoholic Steatohepatitis (NASH) Commercial Opportunities - Pipeline Analysis & Forecast Report
M2 - Mon Dec 07, 8:47AM CST
Research and Markets (http://www.researchandmarkets.com/research/p3853f/nonalcoholic) has announced the addition of the "Nonalcoholic steatohepatitis (NASH) - Pipeline Analysis" report to their offering. NASH Facts: - 10% of the adult population in U.S has NASH - NASH can occur in all age groups and even in children but mostly it is diagnosed in the patients between the age of 40-60 - NASH affects between 9.5-16 million people in United States accounting for 3 to 5 % of the population - NASH is a third leading and rapidly increasing indication for liver transplants accounting for 10% of liver transplants in U.S. - In America, the obesity rate has doubled in adults and tripled in children in the past 10 years which would impact the prevalence of NASH in the coming years, being one of the major risk factors for NASH - NASH has the potential to become one of the leading cause of end stage liver disease, liver transplantation, and hepatocellular carcinoma in the next decades This report enables Pharmaceutical/Biotech companies, Academic institutes, Individual researchers, Investors, Medical technology companies, Service providers and other associated stake holders to identify and analyze the available licensing/collaborative commercial opportunities in the Nonalcoholic steatohepatitis (NASH) Drug market. The report also provides strategic insights on medicines that are likely to have an impact on future NASH treatment space. As some of the candidates are nearing key R&D milestones, there is a huge competition among large pharmaceutical and biotech companies to acquire these assets. Gilead's acquisition of Phenex FXR program & Boehringer's acquisition of NASH clinical asset from Pharmaxis supports this trend. Diagnosis of NASH still requires histological confirmation and there is a great demand for specific non-invasive diagnosis for distinguishing NASH from other liver diseases. Therefore, there is a need to develop better diagnostic and therapeutic strategies for patients with NASH. There is a tremendous opportunity for upcoming therapies specific to NASH such as MAbs, RNA-based therapies & Recombinant proteins. These modalities may provide Anti-fibrosis, Anti-inflammatory and metabolic benefits. Companies Mentioned: - Boehringer Ingelheim - Cerenis Therapeutics - Connexios Life Sciences - Genfit - Gilead Sciences - Intercept - Islet Sciences - Nimbus Therapeutics - Verva Pharmaceuticals - Viking Therapeutics Report Structure: 1. Report Description 2. Introduction 3. Hot Targets, Mechanisms & Therapies 4. Market Data 5. Pipeline Analysis 6. Small Molecules 7. Large Molecule 8. RNA-based Therapy 9. Recombinant Proteins 10. Antibodies 11. Large Molecules (Unspecified) 12. Other Molecules 13. NASH Drug Analysis based on Mechanisms 14. Major Players 15. References For more information visit http://www.researchandmarkets.com/research/p3...nalcoholic
GILD: 79.77 (-0.31), VKTX: 1.39 (+0.08)
Islet Sciences Appoints Chief Financial and Chief Operating Officer
ACCESSWIRE - Wed Oct 21, 3:05PM CDT
Seasoned Financial Executive, David E. Wilder, Joins Biopharmaceutical Company
Former American Diabetes Association Executive Chairman and Eli Lilly Executive Joins Islet Sciences as Chairman, President and CEO
ACCESSWIRE - Thu Oct 01, 3:54PM CDT
Larry K. Ellingson, Proven Pharmacy Executive, Adds Significant Diabetes and Public Company Expertise
Diabetic Retinopathy Therapeutics Pipeline Review, H1 2015 - 34 Companies & 50 Drug Profiles
M2 - Tue Jul 21, 3:44AM CDT
Research and Markets (http://www.researchandmarkets.com/research/7fgxcs/diabetic) has announced the addition of the "Diabetic Retinopathy - Pipeline Review, H1 2015" report to their offering. This report provides comprehensive information on the therapeutic development for Diabetic Retinopathy, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Diabetic Retinopathy and special features on late-stage and discontinued projects. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Companies Involved in Therapeutics Development - Acucela Inc. - Aerpio Therapeutics, Inc. - Angstrom Pharmaceuticals, Inc. - Antisense Therapeutics Limited - Aprogen, Inc. - BioDiem Ltd - Biomar Microbial Technologies - Charlesson LLC. - Crinetics Pharmaceuticals, Inc. - Dimerix Bioscience Pty Ltd - EyeGene, Inc. - Foresee Pharmaceuticals, LLC - GTx, Inc. - Icon Bioscience, Inc. - IMMD Inc. - Islet Sciences, Inc. - Kowa Company, Ltd. - LegoChem Biosciences, Inc - MacuCLEAR, Inc. - MingSight Pharmaceuticals - Molecular Design International, Inc. - OcuCure Therapeutics, Inc. - Ohr Pharmaceutical Inc. - PanOptica, Inc. - Promedior, Inc. - R-Tech Ueno, Ltd. - Resolvyx Pharmaceuticals, Inc - RestorGenex Corporation - Sirnaomics, Inc. - Stelic Institute & Co. - Stemedica Cell Technologies, Inc. - Targazyme, Inc. - ThromboGenics NV - TWi Pharmaceuticals, Inc. Drug Profiles - 49-B - A-6 - A-717 - AC-301 - AKB-9778 - ALG-1001 - AP-202 - ATL-1103 - BDM-E - Beta-LGND2 - CLT-01001 - CLT-01007 - CLT-01012 - cyclosporine - Cyndacel-M - DG-3173 - DMX-200 - Drug to Activate EGF-Like-Domain Multiple 7 for Oncology and Diabetic Retinopathy - DT-23552 - E-1086 - EG-Mirotin - emixustat hydrochloride - FP-008 - IB-09A0133 - IMD-0354 - JP-153 - L-779976 - LCB-030110 For more information visit http://www.researchandmarkets.com/research/7fgxcs/diabetic
GTXI: 0.59 (+0.01), OHRP: 2.73 (+0.04)
Nonalcoholic steatohepatitis (NASH) - 2015 Pipeline Analysis
M2 - Tue Jul 21, 3:00AM CDT
Research and Markets (http://www.researchandmarkets.com/research/kf56cl/nonalcoholic) has announced the addition of the "Nonalcoholic steatohepatitis (NASH) - Pipeline Analysis" report to their offering. This report gives comprehensive insight on the various drugs being developed for the treatment of NASH. The report covers all the drugs being developed in various phases (Discovery, Preclinical & Clinical development). The pipeline focuses on novel medicines covering small molecules, monoclonal antibodies, Recombinant proteins and RNA-based therapeutics, but excludes Off-label, symptom relief drugs, generic combinations. The report also covers hot targets in research for NASH treatments and disease progression biomarkers. This report enables Pharmaceutical/Biotech companies, Academic institutes, Individual researchers, Investors, Medical technology companies, Service providers and other associated stake holders to identify and analyze the available licensing/collaborative commercial opportunities in the Nonalcoholic steatohepatitis (NASH) Drug market. The report also provides strategic insights on medicines that are likely to have an impact on future NASH treatment space. NASH is associated with fatty liver, hepatic inflammation, hepatocyte injury and fibrogenesis and may worsen into fibrosis or cirrhosis, liver failure and rarely into liver cancer. Currently, there are no approved drugs for NASH by U.S. Food and Drug Administration (FDA) and there a high unmet clinical need. NASH, if untreated can progress to liver-destroying cirrhosis and potentially cancer. Majority of the NASH pipeline drugs are from specialised small to mid pharmaceutical & biotech companies. As some of the candidates are nearing key R&D milestones, there is a huge competition among large pharmaceutical and biotech companies to acquire these assets. Gilead's acquisition of Phenex FXR program & Boehringer's acquisition of NASH clinical asset from Pharmaxis supports this trend. Diagnosis of NASH still requires histological confirmation and there is a great demand for specific non-invasive diagnosis for distinguishing NASH from other liver diseases. Therefore, there is a need to develop better diagnostic and therapeutic strategies for patients with NASH. There is a tremendous opportunity for upcoming therapies specific to NASH such as MAbs, RNA-based therapies & Recombinant proteins. These modalities may provide Anti-fibrosis, Anti-inflammatory and metabolic benefits. Key Topics Covered: 1. Report Description 2. Introduction 3. Hot Targets, Mechanisms & Therapies 4. Market Data 5. Pipeline Analysis 6. Small Molecules 7. Large Molecule 8. RNA-based Therapy 9. Recombinant Proteins 10. Antibodies 11. Large Molecules (Unspecified) 12. Other Molecules 13. NASH Drug Analysis based on Mechanisms 14. Major Players - Boehringer Ingelheim - Cerenis Therapeutics - Connexios Life Sciences - Genfit - Gilead Sciences - Intercept - Islet Sciences - Nimbus Therapeutics - Verva Pharmaceuticals - Viking Therapeutics For more information visit http://www.researchandmarkets.com/research/kf...nalcoholic
GILD: 79.77 (-0.31), VKTX: 1.39 (+0.08)
Global Diabetic Nephropathy Pipeline Review, H1 2015
M2 - Tue Jun 02, 7:58AM CDT
Research and Markets (http://www.researchandmarkets.com/research/frxw7k/diabetic) has announced the addition of the "Diabetic Nephropathy - Pipeline Review, H1 2015" report to their offering. This report provides comprehensive information on the therapeutic development for Diabetic Nephropathy, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Diabetic Nephropathy and special features on late-stage and discontinued projects. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Companies Involved in Therapeutics Development - AbbVie Inc. - Aerpio Therapeutics, Inc. - Antisense Therapeutics Limited - Astellas Pharma Inc. - AstraZeneca PLC - Bayer AG - Bristol-Myers Squibb Company - Cellmid Limited - ChemoCentryx, Inc. - Concert Pharmaceuticals, Inc. - CTI BioPharma Corp. - Daiichi Sankyo Company, Limited - DiaMedica Inc. - Dimerix Bioscience Pty Ltd - Dong Wha Pharma Co., Ltd. - Eli Lilly and Company - Galectin Therapeutics, Inc. - GenKyoTex S.A. - Gentium S.p.A. - Gilead Sciences, Inc. - GlaxoSmithKline plc - Glucox Biotech AB - GNI Group Ltd. - IMMD Inc. - Intercept Pharmaceuticals, Inc. - InterMune, Inc. - Inventiva SAS - Islet Sciences, Inc. - Jenrin Discovery, Inc. - Johnson & Johnson - Mallinckrodt plc - Mesoblast Limited - Mitsubishi Tanabe Pharma Corporation - NephroGenex, Inc. - Noxxon Pharma AG For more information visit http://www.researchandmarkets.com/research/frxw7k/diabetic
NRX: 0.14 (+0.01), GALT: 1.62 (-0.15), LLY: 78.24 (+0.23), GSK: 43.55 (-0.19), BMY: 58.77 (+0.01), CTIC: 0.35 (+0.01), CNCE: 10.14 (-0.49), JNJ: 119.04 (+0.47), GILD: 79.77 (-0.31), AZN: 33.05 (-0.18), CCXI: 5.00 (+0.16), ICPT: 154.96 (+1.32), ABBV: 64.61 (-0.11)
Islet Sciences, Inc. Publishes Data Supporting Remogliflozin Etabonate as a Potential Treatment for NAFLD and NASH
GlobeNewswire - Mon May 04, 6:47AM CDT
Islet Sciences, Inc. (OTCQB:ISLT), a biopharmaceutical company developing new medicines and technologies for the treatment and diagnosis of metabolic disease, has announced publication of pre-clinical data that demonstrates remogliflozin etabonate has significant potential as a novel therapeutic for the treatment of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).
Islet Sciences, Inc. Presented at 50th International Liver Conference
GlobeNewswire - Thu Apr 23, 11:02AM CDT
Islet Sciences, Inc. (OTCQB:ISLT), a biopharmaceutical company developing new medicines and technologies for the treatment of metabolic disease, announced today that Chief Operating Officer, Dr. William Wilkison presented "Remogliflozin Etabonate Reduces Insulin Resistance and Liver Function Enzymes: Role for Treatment of NASH" at the 50th International Liver Conference hosted by the European Association for the Study of Liver (EASL) in Vienna, Austria.
Islet Holdings, Inc. Continues With Pursuing Damages in Federal Court
GlobeNewswire - Thu Mar 26, 7:11AM CDT
Islet Holdings, Inc. (OTC:ISHI) ("the Company"
previously announced that in August 2012, the Company and its subsidiary filed a complaint in Federal District Court for the District of Utah against Islet Sciences, Inc., a publicly-held company trading under the symbol "ISLT", and several individuals intimately involved with Islet Sciences. The complaint is related to the Company's prior work and development in the type 1 diabetes treatment industry. Islet Sciences, Inc. COO to Present at Metabolic Leaders Forum
GlobeNewswire - Tue Mar 24, 6:55AM CDT
Islet Sciences, Inc. (OTCQB:ISLT), a biopharmaceutical company developing new medicines and technologies for the treatment of metabolic disease, announced today that Chief Operating Officer, Dr. William Wilkison, will present data on remogliflozin etabonate and its efficacy and safety in the treatment of type 2 diabetes and NAFLD/NASH as well as participating in a panel discussion at the Metabolic Leaders Forum 2015 in Boston, MA on March 24th.
Islet Sciences, Inc. COO to Present at EASL: Remogliflozin Etabonate as Novel Treatment for Non-alcoholic Steatohepatitis (NASH)
GlobeNewswire - Mon Mar 09, 7:07AM CDT
Islet Sciences, Inc. (OTCQB:ISLT), a biopharmaceutical company developing new medicines and technologies for the treatment of metabolic disease, announced today that Chief Operating Officer, Dr. William Wilkison, was invited to present clinical and preclinical data highlighting the unique properties of selective sodium glucose transporter 2 (SGLT2) inhibitor, remogliflozin etabonate, as a novel treatment for non-alcoholic steatohepatitis (NASH) and its precursor, non-alcoholic fatty liver disease (NAFLD). The data will be presented at the 50th International Liver Conference held in Vienna, Austria April 22 - 26, 2015 by the European Association for the Study of Liver (EASL).
