Repost This part could easily be overlooked. "
Post# of 72440
Posted On: 05/24/2016 11:24:36 AM
Repost
This part could easily be overlooked.
" 43.7% of patients in the 200mg Prurisol arm would have met the primary endpoint. Patient responses in the 50mg and 100mg arms were statistically comparable to the placebo arm.
This seems to definitely point to a dose dependent response since the response rates weren't mixed among the dosing arms. Now they know the minimum effective dosing and can likely increase that, since the only SAE was in the 50mg arm not the 200 mg arm. It's follows that efficacy will improve even further with a higher dose IMO.
This part could easily be overlooked.
" 43.7% of patients in the 200mg Prurisol arm would have met the primary endpoint. Patient responses in the 50mg and 100mg arms were statistically comparable to the placebo arm.
This seems to definitely point to a dose dependent response since the response rates weren't mixed among the dosing arms. Now they know the minimum effective dosing and can likely increase that, since the only SAE was in the 50mg arm not the 200 mg arm. It's follows that efficacy will improve even further with a higher dose IMO.
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