A link from patent and trademark office on "Plus"
Post# of 1460
https://drive.google.com/file/d/0B4aGhjyMOhXx...sp=sharing
From a north40000 PM to me about AVXL patent.
PTO examiner may have established a prima facie case that the claimed invention would have been obvious to of ordinary skill in the art. Evidence may be submitted to rebut that rejection...evidence that the particular claimed combination has superiority beyond what one of ordinary skill would expect is an example.
Matters may not be so dire...I expect affidavit evidence with supporting data to support affiant's opinion of non-obviousness in light of data would be filed...will study further.
BTW, north40000 is a patent attorney,
Fletch