Study Shows BioPharmX Formulation Offers More Effe
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Posted On: 11/04/2015 9:27:06 AM
Study Shows BioPharmX Formulation Offers More Effective Acne Treatment by Targeted Delivery of Minocycline
Research suggests a 1% dose could work as well as 4% topical products under development; lower doses reduce the likelihood of undesirable side effects
MENLO PARK, Calif., Nov. 4, 2015 /PRNewswire/ -- BioPharmX Corporation (NYSE MKT: BPMX), a specialty pharmaceutical company developing products for use in dermatology and women's health, announced today that research being presented at the Skin Disease Education Foundation's 16th Annual Las Vegas Dermatology Seminar shows that a unique formulation of minocycline known as BPX-01 may offer a breakthrough in acne treatment because it can deliver the antibiotic to the area of skin where acne develops. Study findings will be shared during the SDEF dermatology meeting Nov. 5-7.

The novel hydrophilic (non oil-based) formulation of minocycline may be more effective than other topical alternatives because they either use less effective antibiotics to penetrate the top layer of skin or rely on higher concentrations of minocycline, which could lead to unpleasant side effects.
BPX-01 is the first and only stable hydrophilic topical gel with fully solubilized minocycline. Minocycline, an antibacterial and anti-inflammatory medicine, is the most commonly prescribed acne treatment because it has a lower resistance rate than other antibiotics. No stable form of hydrophilic topical minocycline is currently commercially available.
"Our preliminary studies in animals indicate that minocycline delivered by BPX-01 is efficiently absorbed into the skin, reaching the epidermis and the pilosebaceous region where acne develops," said Kin F. Chan, Ph.D., executive vice president of research and development at BioPharmX Corporation. "The results suggest that lower doses of the antibiotic may be used to provide a treatment that is superior to higher-dose topical formulations and oral therapies."
Topical targeted formulations are preferable to oral dosing that can have,side effects such as diarrhea, nausea, and dizziness that can discourage compliance. Lipophilic (oil-based) topical antibiotic products are occlusive and can compromise drug delivery. To compensate for the inefficiency, some products use less effective antibiotics while others rely on significantly higher concentrations of antibiotics. The BioPharmX research found that the hydrophilic BPX-01 formulation distributes evenly, is not sticky and does not occlude or irritate the skin, an advantage in the treatment of acne.
Dermatologists often prescribe combinations of oral minocycline and topical products to treat the skin where acne conditions develop, but have never had an option for a topical minocycline solution.
The American Academy of Dermatology calls acne the "most common skin condition in the United States," affecting 40 million to 50 million American at any given moment. The disease can cause permanent scarring, low self-esteem, depression and anxiety.
Research suggests a 1% dose could work as well as 4% topical products under development; lower doses reduce the likelihood of undesirable side effects
MENLO PARK, Calif., Nov. 4, 2015 /PRNewswire/ -- BioPharmX Corporation (NYSE MKT: BPMX), a specialty pharmaceutical company developing products for use in dermatology and women's health, announced today that research being presented at the Skin Disease Education Foundation's 16th Annual Las Vegas Dermatology Seminar shows that a unique formulation of minocycline known as BPX-01 may offer a breakthrough in acne treatment because it can deliver the antibiotic to the area of skin where acne develops. Study findings will be shared during the SDEF dermatology meeting Nov. 5-7.

The novel hydrophilic (non oil-based) formulation of minocycline may be more effective than other topical alternatives because they either use less effective antibiotics to penetrate the top layer of skin or rely on higher concentrations of minocycline, which could lead to unpleasant side effects.
BPX-01 is the first and only stable hydrophilic topical gel with fully solubilized minocycline. Minocycline, an antibacterial and anti-inflammatory medicine, is the most commonly prescribed acne treatment because it has a lower resistance rate than other antibiotics. No stable form of hydrophilic topical minocycline is currently commercially available.
"Our preliminary studies in animals indicate that minocycline delivered by BPX-01 is efficiently absorbed into the skin, reaching the epidermis and the pilosebaceous region where acne develops," said Kin F. Chan, Ph.D., executive vice president of research and development at BioPharmX Corporation. "The results suggest that lower doses of the antibiotic may be used to provide a treatment that is superior to higher-dose topical formulations and oral therapies."
Topical targeted formulations are preferable to oral dosing that can have,side effects such as diarrhea, nausea, and dizziness that can discourage compliance. Lipophilic (oil-based) topical antibiotic products are occlusive and can compromise drug delivery. To compensate for the inefficiency, some products use less effective antibiotics while others rely on significantly higher concentrations of antibiotics. The BioPharmX research found that the hydrophilic BPX-01 formulation distributes evenly, is not sticky and does not occlude or irritate the skin, an advantage in the treatment of acne.
Dermatologists often prescribe combinations of oral minocycline and topical products to treat the skin where acne conditions develop, but have never had an option for a topical minocycline solution.
The American Academy of Dermatology calls acne the "most common skin condition in the United States," affecting 40 million to 50 million American at any given moment. The disease can cause permanent scarring, low self-esteem, depression and anxiety.
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