Futures down hugely at about midnight eastern time

Futures down hugely at about midnight eastern time, but no way of telling where they'll be at the open. I remember times in the past where they were down like this and then the open the next morning was only slightly red.

My only conclusion is not to draw any conclusions tomorrow morning. If I were the CEO of CTIX, I would sure wait if I could to put out any press release until the market stabilizes and my good news wouldn't get lost in the shuffle.