PORT HUENEME, CA--(Marketwired - Apr 30, 2015) - Stellar Biotechnologies, Inc. ("Stellar" or the "Company") (
The abstract titled " Measuring the Properties of Different Forms of KLH Reveals Important Differences " will be presented at IMMUNOLOGY 2015 in a poster session at the Annual Meeting of the American Association of Immunologists (AAI) (May 8-12, 2015) at the Ernest Morial Convention Center in New Orleans, Louisiana.
The abstract is authored by Stellar Biotechnologies scientists Shuguang Bi, Ph.D., Laura Milbrandt, and Catherine Brisson, Ph.D. The Company will also exhibit at the AAI meeting (Booth # 648).
KLH is widely used as a carrier protein in immunotherapy vaccine development for diseases such as cancer, immune disorders, inflammatory diseases, and Alzheimer's. KLH is also used extensively in drug immunotoxicology to measure T-cell dependent antibody response.
The poster presentation is a report on Stellar's research in developing functional assays to evaluate the immunogenicity of different forms and preparations of KLH.
"We know that different forms of KLH can elicit different immune responses, so we are developing test methods to identify the suitable form of KLH for any given application," said Dr. Catherine Brisson, Chief Operating Officer at Stellar. "Our goal is to improve the predictive outcome when using KLH as an immunotherapy vaccine carrier or diagnostic immunogen, whether in clinical or research applications."
The poster recaps recent preclinical studies conducted by Stellar comparing the efficiency of various types of KLH to elicit KLH-specific and antigen-specific adaptive immune responses. Dendritic cells (DCs) derived from animal and human cell lines as well as mouse bone marrow mononuclear cells and human peripheral blood mononuclear cells (PBMC) were treated with different forms and preparations of KLH. DC antigen uptake, DC maturation, T-cell proliferation, and cytokine secretion were compared. The studies reveal significantly different responses, the results of which support the need for methods to identify appropriate forms of KLH when used as a hapten carrier or immunogen.
IMMUNOLOGY 2015 Poster Presentation Title: Measuring the Properties of Different Forms of KLH Reveals Important Differences Session: Vaccines and Immunotherapy Date & Time: Saturday, May 9, 2015, 2:30pm - 3:45pm Central (12:30pm - 1:45pm Pacific) Presenter: Shuguang Bi Link to poster abstract: https://immunology2015.zerista.com/poster/member/35107 Visit Stellar at AAI Booth # 648.
About Immunology 2015 Immunology 2015, the Annual Meeting of The American Association of Immunologists (AAI), ( www.immunology2015.org ) brings together the world leaders in immunology to present their research in lectures and major symposia. The AAI is an association of professionally trained scientists from all over the world dedicated to advancing the knowledge of immunology and its related disciplines, fostering the interchange of ideas and information among investigators, and addressing the potential integration of immunologic principles into clinical practice. AAI owns and publishes The Journal of Immunology.
Stellar Biotechnologies, Inc. (
Visit www.stellarbiotech.com and the Stellar KLH knowledge base www.klhsite.org .
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Stellar Biotechnologies Company Contact: Mark A. McPartland Vice President of Corporate Development and Communications Phone: +1 (805) 488-2800 ext. 103 markmcp@stellarbiotech.com www.stellarbiotech.com
