A snapshot of the hard work, built over time, to t
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Posted On: 03/12/2015 5:12:02 PM
A snapshot of the hard work, built over time, to the growing value and increasing potential of RGBP/BMSN
June 06, 2012 08:30 ET
Bio-Matrix' Regen BioPharma Unit Establishes Scientific Advisory Board and Research Relationship With Clinartis in Anticipation of Beginning Clinical Development Stem Cell Studies
SAN DIEGO, CA--(Marketwire - Jun 6, 2012) -
World renowned experts to accelerate development of stem cell therapeutics
Regen anticipates new relationship with Clinartis to fast track clinical studies
Bio-Matrix Scientific Group (OTCQB: BMSN) (PINKSHEETS: BMSN) announced today that its Regen BioPharma unit has appointed three internationally renowned regenerative medicine experts to its Scientific Advisory Board (SAB). The new SAB members appointed are David White, M.D., PhD; Wei-Ping Min, M.D., PhD and Vlad Bogin, M.D.
Dr. White is a member of the Surgery and Immunology faculty of The Schulic School of Medicine, University of Western Ontario. He is one of the leading experts on using regenerative medicine transplant procedures to treat pancreatic conditions, including diabetes. He is also the Chief Scientific Officer of Sernova Corp and was formerly a Therapeutic Area Head for Novartis. He received the B.Sc. degree from the University of Surrey and the M.D. and PhD degrees from Cambridge University.
Dr. Wei-Ping Min is Professor at the Lawson Health Research Center in Canada. He is inventor of siRNA therapeutics in the area of immunology and cell therapy to inhibit disease modalities. He is also the founder/cofounder of several biotech companies including MedVax Pharma Corp, and ToleroTech Inc. Dr. Min brings detailed scientific and mechanistic expertise to Regen BioPharma. He earned graduate and medical degrees from Nanchang University Medical School and the PhD degree from Kyushu University.
Dr. Bogin is the President and CEO of Cromos Pharma, a contract research organization that specializes in biopharmaceutical clinical outsourcing. He was formerly the Director of Boehringer Ingelheim in charge of the phase IV program for Dabigatran Etexilate. He studied at the Yale University School of Medicine and the University of Rochester School of Medicine and Dentistry.
Regen BioPharma has also entered into a Letter of Intent with Clinartis LLC, a global contract research organization (CRO). Clinartis is a full service global CRO serving pharmaceutical, biotech and medical device companies to support Phase I - IV drug and device clinical trials in the US and Europe.
The SAB and Clinartis will assist the Company in its acquisition of intellectual property related to stem cells, translation of the intellectual property into treatments, and optimizing the value of these new therapies.
"The potential of regenerative medicine products is significant," says Christopher Mizer, the President of Regen BioPharma. "We believe that strategic collaborative relationships between Regen BioPharma, our SAB and Clinartis will facilitate our efforts to create value from that potential by developing proprietary, life sciences technologies and demonstrating their clinical utility."
"Our strong SAB has scientific and regulatory expertise, coupled with Clinartis' access to world-class researchers and investigators will be very instrumental for accelerated commercialization of the cutting-edge biotechnology research on which Regen BioPharma is focused," according to Bio-Matrix Scientific Group's Chairman & CEO David Koos.
About Bio-Matrix Scientific Group Inc. and Regen BioPharma, Inc.:
Bio-Matrix Scientific Group, Inc. (OTCQB: BMSN) (PINKSHEETS: BMSN) is a biotechnology company focused on the development of regenerative medicine therapies and tools. The Company is focused on human therapies that address unmet medical needs. Specifically, Bio-Matrix Scientific Group Inc. is looking to increase the quality of life through therapies involving stem cell treatments. These treatments are focused in areas relating to cardiovascular, hematology, oncology and other indications.
Through Its wholly owned subsidiary, Regen BioPharma, it is the Company's goal to develop translational medicine platforms for the rapid commercialization of stem cell therapies. The Company is looking to use these translational medicine platforms to advance intellectual property licensed from entities, institutions and universities that show promise towards fulfilling the Company's goal of increased quality of life.
Disclaimer
This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward-looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
http://www.marketwired.com/press-release/bio-...665962.htm
June 07, 2012 08:30 ET
Bio-Matrix Scientific Group's Regen BioPharma Subsidiary Executes Option Agreement to License Stem Cell Intellectual Property
SAN DIEGO, CA--(Marketwire - Jun 7, 2012) - Bio-Matrix Scientific Group, Inc. (OTCQB: BMSN) (PINKSHEETS: BMSN) announced today that its wholly owned subsidiary Regen BioPharma, Inc. has executed an exclusive option agreement which grants Regen BioPharma an option to license Patent #6,821,513 which patents methods of stimulating blood production in patients with deficient stem cells. The patent, as well as data licensed with the patent, covers methods of stimulating the bone marrow to generate new blood cells. The patent and option agreement are disclosed in the Company's most recent 8K filed with the US Securities and Exchange Commission on June 6, 2012.
"The technology has broad applicability to help cancer patients recover faster following chemotherapy, as well as for recipients of bone marrow and cord blood transplants. Currently, new blood cell production is stimulated by expensive drugs such as Neupogen and Neulasta which replicate the body's growth factors but can cause side effects and rely upon the diminished recuperative powers of an immune compromised patient," stated J. Christopher Mizer, President of Regen BioPharma.
David Koos, Chairman & CEO of Bio-Matrix Scientific Group, added, "We are excited to get this therapy into the clinic. Based on peer-reviewed published animal data, it has the potential to restore immune function faster and more effectively than the existing standard of care."
The licensed technology covers the use of a naturally-occurring cell type for stimulation of bone marrow stem cells. By utilizing cells as opposed to drugs, Regen BioPharma believes it possesses a substantial advantage to existing approaches in terms of safety and economics of production. Currently the market for growth factors that stimulate blood making stem cells is more than $4.84 billion per year (www.wikinvest.com/stock/Amgen).
About Bio-Matrix Scientific Group Inc. and Regen BioPharma, Inc.:
Bio-Matrix Scientific Group, Inc. (OTCQB: BMSN) (PINKSHEETS: BMSN) is a biotechnology company focused on the development of regenerative medicine therapies and tools. The Company is focused on human therapies that address unmet medical needs. Specifically, Bio-Matrix Scientific Group Inc. is looking to increase the quality of life through therapies involving stem cell treatments. These treatments are focused in areas relating to cardiovascular, hematology, oncology and other indications.
Through Its wholly owned subsidiary, Regen BioPharma, it is the Company's goal to develop translational medicine platforms for the rapid commercialization of stem cell therapies. The Company is looking to use these translational medicine platforms to advance intellectual property licensed from entities, institutions and universities that show promise towards fulfilling the Company's goal of increased quality of life.
Disclaimer
This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward-looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
http://www.marketwired.com/press-release/bio-...666586.htm
September 16, 2014 11:43 ET
Regen BioPharma Files Patent Application on New Therapy That Uses the "Innate" Immune System to Kill Cancer
Invention Leverages Research Discoveries in Development of dCellVax for New Cancer Immunotherapy Product
SAN DIEGO, CA--(Marketwired - Sep 16, 2014) - Regen BioPharma Inc. (OTCBB: RGBP) announced today filing of a patent application covering novel means of stimulating the "innate" immune system to kill cancer. The patent discloses specific siRNA molecules that were discovered by Regen BioPharma during the preclinical development of dCellVax. Preliminary data generated by the Company suggests that the new approach appears effective against various human cancers including lung, skin, glioma, and breast cancer.
The patent application describes the utilization of gene silencing, which is the basis of the Company's dCellVax product, together with specific peptides that have previously been demonstrated to stimulate aspects of the innate immune system that is effective at inducing tumor regression.
"To my knowledge there is only one reproducible system in which cancer is destroyed by the immune system, this is the SR/CR mice developed by Wake Forest University1. In these mice, which are resistant to challenges with various tumors, the 'innate' and not the 'adaptive' immune system is responsible for eradication of the cancer," said Thomas Ichim, Ph.D., Chief Scientific Officer of Regen BioPharma. "By following the example of nature and focusing augmenting immune responses that are already known to be effective, we believe we are pioneering a novel approach to treatment of cancer."
The immune system is divided into "innate," which recognizes threats to the body regardless of prior exposures to the threat, and "adaptive," which recognizes threats that the body has previously been exposed to. The majority of cancer immunotherapies in clinical development and FDA trials, including checkpoint inhibitors and CAR-T cells work through the "adaptive" immune system.
"While our efforts are focused on moving forward towards initiation of our HemaXellerate clinical trial and filing the IND for dCellVax, intellectual property on these novel products positions us for the possibility of licensing and co-development deals, which does not detract from the core developmental operations," said David Koos, Ph.D., Chairman & CEO of Regen BioPharma Inc.
The Company is currently preparing to file an IND application on its dCellVax therapy, which involves gene silencing for treating cancer.
About Regen BioPharma Inc.: Regen BioPharma Inc. (OTCBB: RGBP) is a majority owned subsidiary of Bio-Matrix Scientific Group, Inc. (PINKSHEETS: BMSN). Regen is a biotechnology company focused on identifying undervalued regenerative medicine applications in the stem cell space and rapidly advancing these technologies through pre-clinical and Phase I/ II clinical trials.
Currently the Company is focused on developing treatments for Aplastic Anemia and a gene silencing therapy for treating cancer. For more information refer to the company's website http://www.regenbiopharma.com/
Disclaimer: This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
References
1 Hicks AM et al. Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proceedings of the National Academy of Sciences USA, 2006, 103:7753.
http://www.marketwired.com/press-release/rege...947770.htm
November 25, 2014 08:30 ET
Regen BioPharma Acquires University of Toronto Cancer Stem Cell Intellectual Property
Company Aims to Use Small Molecule and Gene Silencing to Target "Root" of Cancer
SAN DIEGO, CA--(Marketwired - Nov 25, 2014) - Regen BioPharma Inc. (OTCBB: RGBP) announced today acquisition of patent application # US 13/652,395 with a priority date of November 2008 which covers a novel gene target essential for the survival of cancer stem cells. Inventors of the intellectual property on which this patent application was filed are University of Toronto Hematologist Dr. Richard Wells and Dr. Christine Ichim, Senior Research Consultant for Regen BioPharma.
The invention is based on findings that leukemic stem cells, which are capable of giving rise to aggressive leukemias, contained high levels of the NR2F6 gene, whereas leukemic cells that are less aggressive and cannot give rise to disease lack this gene. Importantly, when the NR2F6 gene was silenced by shRNA in leukemic stem cells, the stem cells lost leukemia forming ability and turned into normal cells. Some of these data were published in the peer-reviewed literature1. Subsequently, it was discovered that the same gene target NR2F6 is also found in cancer stem cells in other types of tumors such as breast, lung, ovarian, and colon2.
"Dr. Christine Ichim has spent over 10 years in identifying the importance of NR2F6 in cancer stem cells and devising means of killing these tumor initiating cells by genetically or chemically blocking NR2F6. We are enthusiastic about adding this new piece of intellectual property to our developmental pipeline," stated David Koos, Chairman & CEO of Regen BioPharma. "The area of cancer stem cells is associated with extremely high valuation at early stages of clinical development. An example of this is the $155 million upfront payment in the Celgene-OncoMed deal last year for preclinical candidates and one candidate in early phase 1.3 Through the acquisition of this intellectual property, which has such an early priority date, we believe we are well-positioned in this exciting new area at the interface between regenerative medicine and oncology."
Cancer stem cells are the subpopulation of cells in a tumor responsible for driving growth and metastasis of the tumor. These cells exhibit certain properties which include the capacity to divide and give rise to new cancer stem cells via a process called self-renewal and the capacity to differentiate or change into the other cells that form the bulk of the tumor. Common cancer drugs target bulk tumor cells but have limited impact on cancer stem cells, thereby not "hitting" the right target and allowing for cancer recurrence and metastases.
"Regen BioPharma has a track record of rapidly translating university originating intellectual property into products, as seen with granting of IND numbers for HemaXellerate and dCellVax. Additionally, the company has recruited top notch translational researchers such as Drs. Amit Patel, David White and David Suhy. I am very excited at the prospects of clinical implementation of the intellectual property that was assigned today," said Thomas Ichim, Ph.D.
About Regen BioPharma Inc.: Regen BioPharma Inc. (OTCBB: RGBP) is a majority owned subsidiary of Bio-Matrix Scientific Group, Inc. (PINKSHEETS: BMSN). Regen is a biotechnology company focused on identifying undervalued regenerative medicine applications in the stem cell space and rapidly advancing these technologies through pre-clinical and Phase I/ II clinical trials. Currently the Company is focused on developing treatments for Aplastic Anemia and a gene silencing therapy for treating cancer. For more information refer to the company's website http://www.regenbiopharma.com/
Disclaimer: This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
1 Ichim et al. Leukemia. 2011 Nov;25(11):1687-96
2 Safe et al. Mol Endocrinol. 2014 Feb;28(2):157-72
3 http://www.drugs.com/news/celgene-oncomed-177...49294.html
http://www.marketwired.com/press-release/rege...971502.htm
January 08, 2015 08:30 ET
Regen BioPharma Inc. Identifies Second Generation Gene Silencing Candidates for Blocking Cancer Stem Cell Gene Target
Company Augments Intellectual Property Portfolio Related to Cancer Stem Cell
SAN DIEGO, CA--(Marketwired - Jan 8, 2015) - Regen BioPharma Inc. (OTCBB: RGBP) announced today the discovery and demonstration of in vitro efficacy of a second generation of gene silencing drug candidates with specificity to the cancer stem cell gene NR2F6.
The Company has rights to an invention covered by a non-provisional patent application disclosing compositions of matter, protocols and methods of use of treatment for cancer and other diseases of aberrant cellular proliferation. The patent covers the use of its proprietary novel candidates administered as short interfering nucleic acid (siNA) antisense, short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA).
Proof-of-concept studies originally identifying NR2F6 as a target for cancer stem cells were performed by Dr. Christine Ichim, senior research consultant with Regen Biopharma, along with scientists at the University of Toronto. These studies showed that silencing of the NR2F6 gene in leukemia cells led to the cells losing their leukemic characteristics. This finding was the subject of a US patent application "Modulation of NR2F6 and methods and uses thereof" which was assigned to Regen BioPharma. The data was subsequently published in the peer-reviewed journal Leukemia1.
"The identification of novel means of more effectively blocking the NR2F6 gene provides a series of therapeutic candidates that we plan to develop as therapeutic agents, initially for leukemia, and subsequently for solid tumors," stated David Koos, Chairman and CEO of Regen BioPharma. "As we plan on rapidly moving these new drugs through the IND process, we want to ensure that our candidates have the most potent in vitro activity possible before engaging in preclinical efficacy and toxicity studies. Accordingly, we believe that the newly identified candidates are exceedingly more potent in activity when compared to the first generation compounds."
Cancer stem cells, also known as the cancer initiating cells, are the cells in a cancer that are tumorigenic, meaning they have the ability to cause formation of new tumors when implanted in animals. Blocking their ability to self-renew by silencing NR2F6 transforms cancer cells in to a non-tumorigenic state by guiding cells toward a process called differentiation and cellular maturation.
"Developing of therapeutics that target cancer stem cells and transform them into non-tumorigenic cells through the process of differentiation is anticipated to dramatically improve the way we treat cancer," said Dr. Christine Ichim. "At a conceptual level, one of the major failures of cancer therapy is the desire to chemically kill the cancer cell. The cancer cell, which possesses properties of normal cells, has protective mechanisms against being killed. Specifically, when chemotherapy is administered, cancer cells start to produce drug resistance proteins, which act as cellular pumps, that remove the chemotherapy from inside of the cell, thus resulting in treatment resistance. In contrast, the approach being developed by Regen involves 'coaxing' the cancer cell to turn into a normal cell."
Stimulation of cancer cells to convert or "differentiate" into normal cells has been previously used successfully in patients with acute promyelocytic leukemia (APL)2, where cure rates of > 80% have been reported by administration of agents that modulate retinoic acid receptor, a nuclear receptor3. The Company is working on the hypothesis that blocking of specific nuclear receptors, may result in a similar type of "leukemic differentiation," which would be applicable to a broader range of cancers.
"The findings of novel candidate sequences to improve gene silencing of NR2F6 is a fundamental advancement in our work towards biologically treating cancer," said Dr. Thomas Ichim, Chief Scientific Officer. "Given that Regen BioPharma is already clinically developing gene-silencing therapeutics in its IND for dCellVax, we anticipate substantial synergy of these programs."
About Regen BioPharma Inc.: Regen BioPharma Inc. (OTCBB: RGBP) is a majority owned subsidiary of Bio-Matrix Scientific Group, Inc. (OTC PINK: BMSN). Regen is a biotechnology company focused on identifying undervalued regenerative medicine applications in the stem cell space and rapidly advancing these technologies through pre-clinical and Phase I/ II clinical trials. Currently the Company is focused on developing treatments for Aplastic Anemia and a gene silencing therapy for treating cancer. For more information refer to the company's website http://www.regenbiopharma.com/
Disclaimer: This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
1 Ichim et al. Identification of a role for the nuclear receptor EAR-2 in the maintenance of clonogenic status within the leukemia cell hierarchy. Leukemia. 2011 Nov;25(11):1687-96
2 Warrell et al. Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid). N Engl J Med 1991; 324:1385-1393.
3 Lo-Coco et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med. 2013 Jul 11;369(2):111-21
http://www.marketwired.com/press-release/rege...981358.htm
March 03, 2015 08:30 ET
Regen BioPharma Inc. Files Patent Application for Treatment of Myelodysplastic Syndrome Utilizing Gene Silencing Therapy
Company Developing Drug Candidate to Potentially Augment HemaXellerate Therapy for Treating Aplastic Anemia
SAN DIEGO, CA--(Marketwired - Mar 3, 2015) - Regen BioPharma Inc. (OTCBB: RGBP) (OTC PINK: RGBP) announced today the filing of patent application # 14,572/574 covering methods, compositions, and protocols for the treatment of myelodysplastic syndrome by gene silencing using Regen's proprietary siRNA therapeutic sequences platform.
Myelodysplastic Syndrome (MDS) is a collection of diseases that include aplastic anemia, a condition where the bone marrow does not produce sufficient numbers of blood cells. Survival for patients with myelodysplastic syndrome is shorter than survival for patients with lung cancer, as treatment options for these patients with MDS are limited.
Patients with myelodysplastic syndrome are often older and cannot tolerate the side effects associated with aggressive chemotherapy regimens (current baseline form of treatment). As a result they are given palliative therapies, like blood transfusions, because curative options do not exist for most patients.
"Regen has filed a patent on a novel form of therapy called differentiation therapy that is expected to have much milder toxicity than chemotherapy. The mechanism of action of the therapeutic in development is to correct the specific genes that prevent the myelodysplastic syndrome stem cell from producing mature blood cells," said Dr. Thomas Ichim, Chief Scientific Officer of Regen BioPharma.
There are currently 3 drugs approved by the FDA for the treatment of myelodysplastic syndrome: Revlimid (Celgene) with $3.767 billion sales in 2012; Vidaza (Celgene) with $823 million in sales in 2012; and Dacogen (Jansen) which generated royalty revenue of $60 million in 2011. Regen sees each of these 3 drugs having benefited a limited patient population. However, Regen believes its gene silencing approach may serve a broader patient population in a more effective manner.
"We are pleased to announce the expansion of the Company's aplastic anemia platform to include myelodysplastic syndromes. While our HemaXellerate product addresses immunological causes of aplastic anemia, the current differentiation product addresses molecular causes," said David Koos, President, CEO, and Chairman of Regen BioPharma. "We see this expanded approach strengthening the treatment model."
ABOUT REGEN BIOPHARMA INC.: Regen BioPharma Inc. is a publicly traded biotechnology company (OTCBB: RGBP) (OTC PINK: RGBP). The Company seeks to identify undervalued regenerative medicine applications in the immunotherapy and stem cell space. The Company is focused on rapidly advancing these technologies through pre-clinical and Phase I/ II clinical trials. Currently the Company is centering on gene silencing therapy for treating cancer, telomeres and small molecule therapies, along with developing stem cell treatments for aplastic anemia.
Disclaimer: This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
http://www.marketwired.com/press-release/rege...996855.htm
March 10, 2015 08:30 ET
Regen BioPharma Acquires Issued Patent and Preclinical Data Package for Targeting Cancer Stem Cell
Regen Has Raised Almost $700,000 From "Angel" Investors Since December 29, 2014 to Finance Its Ongoing Research
SAN DIEGO, CA--(Marketwired - Mar 10, 2015) - Regen BioPharma Inc. (OTCBB: RGBP) (OTC PINK: RGBP) announced today successful closing of a transaction resulting in acquisition of issued US patent #8,263,571, and associated preclinical data package. The intellectual property covers specific therapeutic agents that gene silence CTCFL. CTCFL, otherwise known as Brother of the Regulator of Imprinted Sites (BORIS) is a gene that is critical for cancer stem cells to survive, in part by inducing expression of telomerase, a protein that creates cellular immortality1.
Thomas Ichim, Ph.D., Chief Scientific Officer of Regen is co-inventor of the patent, which was filed in October 2007 by Vendevia Group. Through a private transaction, Dr. Ichim obtained assignment of the patent and preclinical package, which was subsequently assigned by Dr. Ichim to Regen.
"Having co-authored the peer-reviewed publication dating back to 2008 in which potent inhibition of breast cancer was demonstrated by gene silencing of CTCFL2, and having assigned my own gene silencing/immunotherapy patent to Regen3, I am highly enthusiastic that this very promising approach to killing cancer stem cells has now been brought under the Regen umbrella." Stated Dr. Wei-Ping Min, Professor of Immunology at the University of Western Ontario and Member of Regen's Scientific Advisory Board. "The use of RNA interference to kill cancer stem cells adds another powerful weapon in Regen's arsenal on the war on cancer."
CTCFL, also termed Brother of the Regulator of Imprinted Sites (BORIS) is a key protein that was originally discovered by Dr. Victor Lobanenkov at the NIH4, which acts as a "master orchestrator" of numerous genes needed for cancer to maintain the properties of cancer5. Dr. Ichim previously co-authored papers with NIH and other academic groups demonstrating that immunotherapy targeting CTCFL results in regression of breast cancer, leukemia, and glioma6,7,8.
"Having worked for several years on developing the CTCFL gene-silencing therapeutic approach, and witnessing first-hand the promise of this technology in terms of specifically targeting tumor stem cells, I am excited that we identified a mechanism of bringing this highly complementary technology into Regen," said Dr. Ichim. "Currently Regen is using gene silencing to block NR2F6 in cancer stem cells. The acquisition of the CTCFL intellectual property allows for performing experiments in parallel, thus significantly reducing developmental costs while doubling the probability of success."
"The possession of an issued US patent in this rapidly evolving space allows for a wide range of possibilities ranging from internal development, to co-development, to outright licensing," said David Koos, Chairman and CEO of Regen. "We have initiated discussions with entities in this industry in order to most rapidly optimize value of this asset."
ABOUT REGEN BIOPHARMA INC.: Regen BioPharma Inc. is a publicly traded biotechnology company (OTCBB: RGBP) (OTC PINK: RGBP). The Company seeks to identify undervalued regenerative medicine applications in the immunotherapy and stem cell space. The Company is focused on rapidly advancing these technologies through pre-clinical and Phase I/ II clinical trials. Currently the Company is centering on gene silencing therapy for treating cancer, telomeres and small molecule therapies, along with developing stem cell treatments for aplastic anemia.
Disclaimer: This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
1 Alberti et al. High expression of hTERT and stemness genes in BORIS/CTCFL positive cells isolated from embryonic cancer cells. PLoS One. 2014 Oct 3;9(10):e109921
2 Dougherty et al. Selective apoptosis of breast cancer cells by siRNA targeting of BORIS. Biochem Biophys Res Commun. 2008 May 23;370(1):109-12
3 http://www.marketwired.com/press-release/bio-...834547.htm
4 Loukinov et al. BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6806-11.
5 Vatolin et al. Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes. Cancer Res. 2005 Sep 1;65(17):7751-62.
6 Loukinov et al. Antitumor efficacy of DNA vaccination to the epigenetically acting tumor promoting transcription factor BORIS and CD80 molecular adjuvant. J Cell Biochem. 2006 Aug 1;98(5):1037-43.
7 Ghochikyan et al. Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites. J Immunol. 2007 Jan 1;178(1):566-73.
8 Mkrtichyan et al. DNA, but not protein vaccine based on mutated BORIS antigen significantly inhibits tumor growth and prolongs the survival of mice. Gene Ther. 2008 Jan;15(1):61-4.
http://www.marketwired.com/press-release/rege...998901.htm
June 06, 2012 08:30 ET
Bio-Matrix' Regen BioPharma Unit Establishes Scientific Advisory Board and Research Relationship With Clinartis in Anticipation of Beginning Clinical Development Stem Cell Studies
SAN DIEGO, CA--(Marketwire - Jun 6, 2012) -
World renowned experts to accelerate development of stem cell therapeutics
Regen anticipates new relationship with Clinartis to fast track clinical studies
Bio-Matrix Scientific Group (OTCQB: BMSN) (PINKSHEETS: BMSN) announced today that its Regen BioPharma unit has appointed three internationally renowned regenerative medicine experts to its Scientific Advisory Board (SAB). The new SAB members appointed are David White, M.D., PhD; Wei-Ping Min, M.D., PhD and Vlad Bogin, M.D.
Dr. White is a member of the Surgery and Immunology faculty of The Schulic School of Medicine, University of Western Ontario. He is one of the leading experts on using regenerative medicine transplant procedures to treat pancreatic conditions, including diabetes. He is also the Chief Scientific Officer of Sernova Corp and was formerly a Therapeutic Area Head for Novartis. He received the B.Sc. degree from the University of Surrey and the M.D. and PhD degrees from Cambridge University.
Dr. Wei-Ping Min is Professor at the Lawson Health Research Center in Canada. He is inventor of siRNA therapeutics in the area of immunology and cell therapy to inhibit disease modalities. He is also the founder/cofounder of several biotech companies including MedVax Pharma Corp, and ToleroTech Inc. Dr. Min brings detailed scientific and mechanistic expertise to Regen BioPharma. He earned graduate and medical degrees from Nanchang University Medical School and the PhD degree from Kyushu University.
Dr. Bogin is the President and CEO of Cromos Pharma, a contract research organization that specializes in biopharmaceutical clinical outsourcing. He was formerly the Director of Boehringer Ingelheim in charge of the phase IV program for Dabigatran Etexilate. He studied at the Yale University School of Medicine and the University of Rochester School of Medicine and Dentistry.
Regen BioPharma has also entered into a Letter of Intent with Clinartis LLC, a global contract research organization (CRO). Clinartis is a full service global CRO serving pharmaceutical, biotech and medical device companies to support Phase I - IV drug and device clinical trials in the US and Europe.
The SAB and Clinartis will assist the Company in its acquisition of intellectual property related to stem cells, translation of the intellectual property into treatments, and optimizing the value of these new therapies.
"The potential of regenerative medicine products is significant," says Christopher Mizer, the President of Regen BioPharma. "We believe that strategic collaborative relationships between Regen BioPharma, our SAB and Clinartis will facilitate our efforts to create value from that potential by developing proprietary, life sciences technologies and demonstrating their clinical utility."
"Our strong SAB has scientific and regulatory expertise, coupled with Clinartis' access to world-class researchers and investigators will be very instrumental for accelerated commercialization of the cutting-edge biotechnology research on which Regen BioPharma is focused," according to Bio-Matrix Scientific Group's Chairman & CEO David Koos.
About Bio-Matrix Scientific Group Inc. and Regen BioPharma, Inc.:
Bio-Matrix Scientific Group, Inc. (OTCQB: BMSN) (PINKSHEETS: BMSN) is a biotechnology company focused on the development of regenerative medicine therapies and tools. The Company is focused on human therapies that address unmet medical needs. Specifically, Bio-Matrix Scientific Group Inc. is looking to increase the quality of life through therapies involving stem cell treatments. These treatments are focused in areas relating to cardiovascular, hematology, oncology and other indications.
Through Its wholly owned subsidiary, Regen BioPharma, it is the Company's goal to develop translational medicine platforms for the rapid commercialization of stem cell therapies. The Company is looking to use these translational medicine platforms to advance intellectual property licensed from entities, institutions and universities that show promise towards fulfilling the Company's goal of increased quality of life.
Disclaimer
This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward-looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
http://www.marketwired.com/press-release/bio-...665962.htm
June 07, 2012 08:30 ET
Bio-Matrix Scientific Group's Regen BioPharma Subsidiary Executes Option Agreement to License Stem Cell Intellectual Property
SAN DIEGO, CA--(Marketwire - Jun 7, 2012) - Bio-Matrix Scientific Group, Inc. (OTCQB: BMSN) (PINKSHEETS: BMSN) announced today that its wholly owned subsidiary Regen BioPharma, Inc. has executed an exclusive option agreement which grants Regen BioPharma an option to license Patent #6,821,513 which patents methods of stimulating blood production in patients with deficient stem cells. The patent, as well as data licensed with the patent, covers methods of stimulating the bone marrow to generate new blood cells. The patent and option agreement are disclosed in the Company's most recent 8K filed with the US Securities and Exchange Commission on June 6, 2012.
"The technology has broad applicability to help cancer patients recover faster following chemotherapy, as well as for recipients of bone marrow and cord blood transplants. Currently, new blood cell production is stimulated by expensive drugs such as Neupogen and Neulasta which replicate the body's growth factors but can cause side effects and rely upon the diminished recuperative powers of an immune compromised patient," stated J. Christopher Mizer, President of Regen BioPharma.
David Koos, Chairman & CEO of Bio-Matrix Scientific Group, added, "We are excited to get this therapy into the clinic. Based on peer-reviewed published animal data, it has the potential to restore immune function faster and more effectively than the existing standard of care."
The licensed technology covers the use of a naturally-occurring cell type for stimulation of bone marrow stem cells. By utilizing cells as opposed to drugs, Regen BioPharma believes it possesses a substantial advantage to existing approaches in terms of safety and economics of production. Currently the market for growth factors that stimulate blood making stem cells is more than $4.84 billion per year (www.wikinvest.com/stock/Amgen).
About Bio-Matrix Scientific Group Inc. and Regen BioPharma, Inc.:
Bio-Matrix Scientific Group, Inc. (OTCQB: BMSN) (PINKSHEETS: BMSN) is a biotechnology company focused on the development of regenerative medicine therapies and tools. The Company is focused on human therapies that address unmet medical needs. Specifically, Bio-Matrix Scientific Group Inc. is looking to increase the quality of life through therapies involving stem cell treatments. These treatments are focused in areas relating to cardiovascular, hematology, oncology and other indications.
Through Its wholly owned subsidiary, Regen BioPharma, it is the Company's goal to develop translational medicine platforms for the rapid commercialization of stem cell therapies. The Company is looking to use these translational medicine platforms to advance intellectual property licensed from entities, institutions and universities that show promise towards fulfilling the Company's goal of increased quality of life.
Disclaimer
This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward-looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
http://www.marketwired.com/press-release/bio-...666586.htm
September 16, 2014 11:43 ET
Regen BioPharma Files Patent Application on New Therapy That Uses the "Innate" Immune System to Kill Cancer
Invention Leverages Research Discoveries in Development of dCellVax for New Cancer Immunotherapy Product
SAN DIEGO, CA--(Marketwired - Sep 16, 2014) - Regen BioPharma Inc. (OTCBB: RGBP) announced today filing of a patent application covering novel means of stimulating the "innate" immune system to kill cancer. The patent discloses specific siRNA molecules that were discovered by Regen BioPharma during the preclinical development of dCellVax. Preliminary data generated by the Company suggests that the new approach appears effective against various human cancers including lung, skin, glioma, and breast cancer.
The patent application describes the utilization of gene silencing, which is the basis of the Company's dCellVax product, together with specific peptides that have previously been demonstrated to stimulate aspects of the innate immune system that is effective at inducing tumor regression.
"To my knowledge there is only one reproducible system in which cancer is destroyed by the immune system, this is the SR/CR mice developed by Wake Forest University1. In these mice, which are resistant to challenges with various tumors, the 'innate' and not the 'adaptive' immune system is responsible for eradication of the cancer," said Thomas Ichim, Ph.D., Chief Scientific Officer of Regen BioPharma. "By following the example of nature and focusing augmenting immune responses that are already known to be effective, we believe we are pioneering a novel approach to treatment of cancer."
The immune system is divided into "innate," which recognizes threats to the body regardless of prior exposures to the threat, and "adaptive," which recognizes threats that the body has previously been exposed to. The majority of cancer immunotherapies in clinical development and FDA trials, including checkpoint inhibitors and CAR-T cells work through the "adaptive" immune system.
"While our efforts are focused on moving forward towards initiation of our HemaXellerate clinical trial and filing the IND for dCellVax, intellectual property on these novel products positions us for the possibility of licensing and co-development deals, which does not detract from the core developmental operations," said David Koos, Ph.D., Chairman & CEO of Regen BioPharma Inc.
The Company is currently preparing to file an IND application on its dCellVax therapy, which involves gene silencing for treating cancer.
About Regen BioPharma Inc.: Regen BioPharma Inc. (OTCBB: RGBP) is a majority owned subsidiary of Bio-Matrix Scientific Group, Inc. (PINKSHEETS: BMSN). Regen is a biotechnology company focused on identifying undervalued regenerative medicine applications in the stem cell space and rapidly advancing these technologies through pre-clinical and Phase I/ II clinical trials.
Currently the Company is focused on developing treatments for Aplastic Anemia and a gene silencing therapy for treating cancer. For more information refer to the company's website http://www.regenbiopharma.com/
Disclaimer: This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
References
1 Hicks AM et al. Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proceedings of the National Academy of Sciences USA, 2006, 103:7753.
http://www.marketwired.com/press-release/rege...947770.htm
November 25, 2014 08:30 ET
Regen BioPharma Acquires University of Toronto Cancer Stem Cell Intellectual Property
Company Aims to Use Small Molecule and Gene Silencing to Target "Root" of Cancer
SAN DIEGO, CA--(Marketwired - Nov 25, 2014) - Regen BioPharma Inc. (OTCBB: RGBP) announced today acquisition of patent application # US 13/652,395 with a priority date of November 2008 which covers a novel gene target essential for the survival of cancer stem cells. Inventors of the intellectual property on which this patent application was filed are University of Toronto Hematologist Dr. Richard Wells and Dr. Christine Ichim, Senior Research Consultant for Regen BioPharma.
The invention is based on findings that leukemic stem cells, which are capable of giving rise to aggressive leukemias, contained high levels of the NR2F6 gene, whereas leukemic cells that are less aggressive and cannot give rise to disease lack this gene. Importantly, when the NR2F6 gene was silenced by shRNA in leukemic stem cells, the stem cells lost leukemia forming ability and turned into normal cells. Some of these data were published in the peer-reviewed literature1. Subsequently, it was discovered that the same gene target NR2F6 is also found in cancer stem cells in other types of tumors such as breast, lung, ovarian, and colon2.
"Dr. Christine Ichim has spent over 10 years in identifying the importance of NR2F6 in cancer stem cells and devising means of killing these tumor initiating cells by genetically or chemically blocking NR2F6. We are enthusiastic about adding this new piece of intellectual property to our developmental pipeline," stated David Koos, Chairman & CEO of Regen BioPharma. "The area of cancer stem cells is associated with extremely high valuation at early stages of clinical development. An example of this is the $155 million upfront payment in the Celgene-OncoMed deal last year for preclinical candidates and one candidate in early phase 1.3 Through the acquisition of this intellectual property, which has such an early priority date, we believe we are well-positioned in this exciting new area at the interface between regenerative medicine and oncology."
Cancer stem cells are the subpopulation of cells in a tumor responsible for driving growth and metastasis of the tumor. These cells exhibit certain properties which include the capacity to divide and give rise to new cancer stem cells via a process called self-renewal and the capacity to differentiate or change into the other cells that form the bulk of the tumor. Common cancer drugs target bulk tumor cells but have limited impact on cancer stem cells, thereby not "hitting" the right target and allowing for cancer recurrence and metastases.
"Regen BioPharma has a track record of rapidly translating university originating intellectual property into products, as seen with granting of IND numbers for HemaXellerate and dCellVax. Additionally, the company has recruited top notch translational researchers such as Drs. Amit Patel, David White and David Suhy. I am very excited at the prospects of clinical implementation of the intellectual property that was assigned today," said Thomas Ichim, Ph.D.
About Regen BioPharma Inc.: Regen BioPharma Inc. (OTCBB: RGBP) is a majority owned subsidiary of Bio-Matrix Scientific Group, Inc. (PINKSHEETS: BMSN). Regen is a biotechnology company focused on identifying undervalued regenerative medicine applications in the stem cell space and rapidly advancing these technologies through pre-clinical and Phase I/ II clinical trials. Currently the Company is focused on developing treatments for Aplastic Anemia and a gene silencing therapy for treating cancer. For more information refer to the company's website http://www.regenbiopharma.com/
Disclaimer: This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
1 Ichim et al. Leukemia. 2011 Nov;25(11):1687-96
2 Safe et al. Mol Endocrinol. 2014 Feb;28(2):157-72
3 http://www.drugs.com/news/celgene-oncomed-177...49294.html
http://www.marketwired.com/press-release/rege...971502.htm
January 08, 2015 08:30 ET
Regen BioPharma Inc. Identifies Second Generation Gene Silencing Candidates for Blocking Cancer Stem Cell Gene Target
Company Augments Intellectual Property Portfolio Related to Cancer Stem Cell
SAN DIEGO, CA--(Marketwired - Jan 8, 2015) - Regen BioPharma Inc. (OTCBB: RGBP) announced today the discovery and demonstration of in vitro efficacy of a second generation of gene silencing drug candidates with specificity to the cancer stem cell gene NR2F6.
The Company has rights to an invention covered by a non-provisional patent application disclosing compositions of matter, protocols and methods of use of treatment for cancer and other diseases of aberrant cellular proliferation. The patent covers the use of its proprietary novel candidates administered as short interfering nucleic acid (siNA) antisense, short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA).
Proof-of-concept studies originally identifying NR2F6 as a target for cancer stem cells were performed by Dr. Christine Ichim, senior research consultant with Regen Biopharma, along with scientists at the University of Toronto. These studies showed that silencing of the NR2F6 gene in leukemia cells led to the cells losing their leukemic characteristics. This finding was the subject of a US patent application "Modulation of NR2F6 and methods and uses thereof" which was assigned to Regen BioPharma. The data was subsequently published in the peer-reviewed journal Leukemia1.
"The identification of novel means of more effectively blocking the NR2F6 gene provides a series of therapeutic candidates that we plan to develop as therapeutic agents, initially for leukemia, and subsequently for solid tumors," stated David Koos, Chairman and CEO of Regen BioPharma. "As we plan on rapidly moving these new drugs through the IND process, we want to ensure that our candidates have the most potent in vitro activity possible before engaging in preclinical efficacy and toxicity studies. Accordingly, we believe that the newly identified candidates are exceedingly more potent in activity when compared to the first generation compounds."
Cancer stem cells, also known as the cancer initiating cells, are the cells in a cancer that are tumorigenic, meaning they have the ability to cause formation of new tumors when implanted in animals. Blocking their ability to self-renew by silencing NR2F6 transforms cancer cells in to a non-tumorigenic state by guiding cells toward a process called differentiation and cellular maturation.
"Developing of therapeutics that target cancer stem cells and transform them into non-tumorigenic cells through the process of differentiation is anticipated to dramatically improve the way we treat cancer," said Dr. Christine Ichim. "At a conceptual level, one of the major failures of cancer therapy is the desire to chemically kill the cancer cell. The cancer cell, which possesses properties of normal cells, has protective mechanisms against being killed. Specifically, when chemotherapy is administered, cancer cells start to produce drug resistance proteins, which act as cellular pumps, that remove the chemotherapy from inside of the cell, thus resulting in treatment resistance. In contrast, the approach being developed by Regen involves 'coaxing' the cancer cell to turn into a normal cell."
Stimulation of cancer cells to convert or "differentiate" into normal cells has been previously used successfully in patients with acute promyelocytic leukemia (APL)2, where cure rates of > 80% have been reported by administration of agents that modulate retinoic acid receptor, a nuclear receptor3. The Company is working on the hypothesis that blocking of specific nuclear receptors, may result in a similar type of "leukemic differentiation," which would be applicable to a broader range of cancers.
"The findings of novel candidate sequences to improve gene silencing of NR2F6 is a fundamental advancement in our work towards biologically treating cancer," said Dr. Thomas Ichim, Chief Scientific Officer. "Given that Regen BioPharma is already clinically developing gene-silencing therapeutics in its IND for dCellVax, we anticipate substantial synergy of these programs."
About Regen BioPharma Inc.: Regen BioPharma Inc. (OTCBB: RGBP) is a majority owned subsidiary of Bio-Matrix Scientific Group, Inc. (OTC PINK: BMSN). Regen is a biotechnology company focused on identifying undervalued regenerative medicine applications in the stem cell space and rapidly advancing these technologies through pre-clinical and Phase I/ II clinical trials. Currently the Company is focused on developing treatments for Aplastic Anemia and a gene silencing therapy for treating cancer. For more information refer to the company's website http://www.regenbiopharma.com/
Disclaimer: This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
1 Ichim et al. Identification of a role for the nuclear receptor EAR-2 in the maintenance of clonogenic status within the leukemia cell hierarchy. Leukemia. 2011 Nov;25(11):1687-96
2 Warrell et al. Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid). N Engl J Med 1991; 324:1385-1393.
3 Lo-Coco et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med. 2013 Jul 11;369(2):111-21
http://www.marketwired.com/press-release/rege...981358.htm
March 03, 2015 08:30 ET
Regen BioPharma Inc. Files Patent Application for Treatment of Myelodysplastic Syndrome Utilizing Gene Silencing Therapy
Company Developing Drug Candidate to Potentially Augment HemaXellerate Therapy for Treating Aplastic Anemia
SAN DIEGO, CA--(Marketwired - Mar 3, 2015) - Regen BioPharma Inc. (OTCBB: RGBP) (OTC PINK: RGBP) announced today the filing of patent application # 14,572/574 covering methods, compositions, and protocols for the treatment of myelodysplastic syndrome by gene silencing using Regen's proprietary siRNA therapeutic sequences platform.
Myelodysplastic Syndrome (MDS) is a collection of diseases that include aplastic anemia, a condition where the bone marrow does not produce sufficient numbers of blood cells. Survival for patients with myelodysplastic syndrome is shorter than survival for patients with lung cancer, as treatment options for these patients with MDS are limited.
Patients with myelodysplastic syndrome are often older and cannot tolerate the side effects associated with aggressive chemotherapy regimens (current baseline form of treatment). As a result they are given palliative therapies, like blood transfusions, because curative options do not exist for most patients.
"Regen has filed a patent on a novel form of therapy called differentiation therapy that is expected to have much milder toxicity than chemotherapy. The mechanism of action of the therapeutic in development is to correct the specific genes that prevent the myelodysplastic syndrome stem cell from producing mature blood cells," said Dr. Thomas Ichim, Chief Scientific Officer of Regen BioPharma.
There are currently 3 drugs approved by the FDA for the treatment of myelodysplastic syndrome: Revlimid (Celgene) with $3.767 billion sales in 2012; Vidaza (Celgene) with $823 million in sales in 2012; and Dacogen (Jansen) which generated royalty revenue of $60 million in 2011. Regen sees each of these 3 drugs having benefited a limited patient population. However, Regen believes its gene silencing approach may serve a broader patient population in a more effective manner.
"We are pleased to announce the expansion of the Company's aplastic anemia platform to include myelodysplastic syndromes. While our HemaXellerate product addresses immunological causes of aplastic anemia, the current differentiation product addresses molecular causes," said David Koos, President, CEO, and Chairman of Regen BioPharma. "We see this expanded approach strengthening the treatment model."
ABOUT REGEN BIOPHARMA INC.: Regen BioPharma Inc. is a publicly traded biotechnology company (OTCBB: RGBP) (OTC PINK: RGBP). The Company seeks to identify undervalued regenerative medicine applications in the immunotherapy and stem cell space. The Company is focused on rapidly advancing these technologies through pre-clinical and Phase I/ II clinical trials. Currently the Company is centering on gene silencing therapy for treating cancer, telomeres and small molecule therapies, along with developing stem cell treatments for aplastic anemia.
Disclaimer: This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
http://www.marketwired.com/press-release/rege...996855.htm
March 10, 2015 08:30 ET
Regen BioPharma Acquires Issued Patent and Preclinical Data Package for Targeting Cancer Stem Cell
Regen Has Raised Almost $700,000 From "Angel" Investors Since December 29, 2014 to Finance Its Ongoing Research
SAN DIEGO, CA--(Marketwired - Mar 10, 2015) - Regen BioPharma Inc. (OTCBB: RGBP) (OTC PINK: RGBP) announced today successful closing of a transaction resulting in acquisition of issued US patent #8,263,571, and associated preclinical data package. The intellectual property covers specific therapeutic agents that gene silence CTCFL. CTCFL, otherwise known as Brother of the Regulator of Imprinted Sites (BORIS) is a gene that is critical for cancer stem cells to survive, in part by inducing expression of telomerase, a protein that creates cellular immortality1.
Thomas Ichim, Ph.D., Chief Scientific Officer of Regen is co-inventor of the patent, which was filed in October 2007 by Vendevia Group. Through a private transaction, Dr. Ichim obtained assignment of the patent and preclinical package, which was subsequently assigned by Dr. Ichim to Regen.
"Having co-authored the peer-reviewed publication dating back to 2008 in which potent inhibition of breast cancer was demonstrated by gene silencing of CTCFL2, and having assigned my own gene silencing/immunotherapy patent to Regen3, I am highly enthusiastic that this very promising approach to killing cancer stem cells has now been brought under the Regen umbrella." Stated Dr. Wei-Ping Min, Professor of Immunology at the University of Western Ontario and Member of Regen's Scientific Advisory Board. "The use of RNA interference to kill cancer stem cells adds another powerful weapon in Regen's arsenal on the war on cancer."
CTCFL, also termed Brother of the Regulator of Imprinted Sites (BORIS) is a key protein that was originally discovered by Dr. Victor Lobanenkov at the NIH4, which acts as a "master orchestrator" of numerous genes needed for cancer to maintain the properties of cancer5. Dr. Ichim previously co-authored papers with NIH and other academic groups demonstrating that immunotherapy targeting CTCFL results in regression of breast cancer, leukemia, and glioma6,7,8.
"Having worked for several years on developing the CTCFL gene-silencing therapeutic approach, and witnessing first-hand the promise of this technology in terms of specifically targeting tumor stem cells, I am excited that we identified a mechanism of bringing this highly complementary technology into Regen," said Dr. Ichim. "Currently Regen is using gene silencing to block NR2F6 in cancer stem cells. The acquisition of the CTCFL intellectual property allows for performing experiments in parallel, thus significantly reducing developmental costs while doubling the probability of success."
"The possession of an issued US patent in this rapidly evolving space allows for a wide range of possibilities ranging from internal development, to co-development, to outright licensing," said David Koos, Chairman and CEO of Regen. "We have initiated discussions with entities in this industry in order to most rapidly optimize value of this asset."
ABOUT REGEN BIOPHARMA INC.: Regen BioPharma Inc. is a publicly traded biotechnology company (OTCBB: RGBP) (OTC PINK: RGBP). The Company seeks to identify undervalued regenerative medicine applications in the immunotherapy and stem cell space. The Company is focused on rapidly advancing these technologies through pre-clinical and Phase I/ II clinical trials. Currently the Company is centering on gene silencing therapy for treating cancer, telomeres and small molecule therapies, along with developing stem cell treatments for aplastic anemia.
Disclaimer: This news release may contain forward-looking statements. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking statements. The risks and uncertainties to which forward looking statements are subject include, but are not limited to, the effect of government regulation, competition and other material risks.
1 Alberti et al. High expression of hTERT and stemness genes in BORIS/CTCFL positive cells isolated from embryonic cancer cells. PLoS One. 2014 Oct 3;9(10):e109921
2 Dougherty et al. Selective apoptosis of breast cancer cells by siRNA targeting of BORIS. Biochem Biophys Res Commun. 2008 May 23;370(1):109-12
3 http://www.marketwired.com/press-release/bio-...834547.htm
4 Loukinov et al. BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6806-11.
5 Vatolin et al. Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes. Cancer Res. 2005 Sep 1;65(17):7751-62.
6 Loukinov et al. Antitumor efficacy of DNA vaccination to the epigenetically acting tumor promoting transcription factor BORIS and CD80 molecular adjuvant. J Cell Biochem. 2006 Aug 1;98(5):1037-43.
7 Ghochikyan et al. Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites. J Immunol. 2007 Jan 1;178(1):566-73.
8 Mkrtichyan et al. DNA, but not protein vaccine based on mutated BORIS antigen significantly inhibits tumor growth and prolongs the survival of mice. Gene Ther. 2008 Jan;15(1):61-4.
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