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Novabay Technology Overview We develop

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Post# of 52
Posted On: 02/19/2012 9:46:24 AM
Posted By: crookedneck




Novabay Technology



Overview


We developed our Aganocide compounds through research and development based on the human body’s natural immune system and the molecules involved in combating infections. The body’s primary defense against infection is the anatomic barrier of the skin and mucous membranes. Once pathogens penetrate the primary defense, the next line of defense is provided by the white blood cells. The most numerous of the white blood cells is the neutrophil. When it encounters a bacterium or other pathogen, the neutrophil engulfs it and generates a series of small molecules with which to destroy it. The process in which these molecules are created is called the “oxidative burst”. These molecules typically have a very short life as they are created “on demand” to accomplish a specific task. We have focused our efforts on understanding these molecules and finding ways, primarily by chemical modification, to impart qualities to them to allow them to be developed as therapeutic products.



Aganocide Compounds


Our proprietary Aganocide compounds work by mimicking our own natural defense against infection. Since our immune system works without ever creating resistance, NovaBay has taken the effective and rapidly acting molecules that function within our own bodies and created stable analogs of these molecules. Our lead Aganocide compound is NVC-422, but we have synthesized several other analogs.


Our Aganocide compounds are:



  • Fast acting

  • Broad in spectrum of activity

  • Effective against multi-drug resistant bacteria

  • Effective against biofilm

  • Have a good safety profile


Fast


Unlike most antibiotics, which can take many hours to kill certain kinds of bacteria, NVC-101 and the Aganocide compounds, even at small doses, can kill bacteria in minutes.


Broad spectrum of activity


NVC-101 and our Aganocide compounds have killed,  in vitro , all bacteria, viruses, yeasts and fungi against which they have been tested.


Effective against multi-drug resistant bacteria


Our Aganocide compounds were highly effective in  in vitro  studies against multi-drug resistant bacteria including Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Enterococcus (VRE).


Effective against biofilm


In data developed at an independent laboratory on our behalf and at our direction, NVC-422 was demonstrated to be highly effective against well-established biofilm grown on urinary tract catheters.


High therapeutic index


Both NVC-101 and NVC-422 demonstrate greater  in vitro  therapeutic index (ratio of toxicity to efficacy) than existing topical antiseptics.



Biofilm


The Center for Integrative Biology and Infectious Diseases of the National Institutes of Health estimates that 80% of all infections in the US involve biofilm. At present, there is no effective treatment that both disrupts the development of biofilm and eradicates the bacteria within. NovaBay’s products, however, have demonstrated in in-vitro and in-vivo studies the ability to penetrate biofilm, as well as to kill microbes sheltered within the biofilm.


Biofilm is often associated with conditions such as:



  • Sinus infections

  • Ear infections

  • Chronic wounds

  • Infections related to cystic fibrosis


Biofilms can also be found on the surface of medical devices such as:

  • Catheters

  • Stents

  • Contact lenses

  • Bone implants

  • Cochlear implants

  • Breast implants


Many bacteria spend much of their existence within a matrix that they create, called biofilm. Biofilm consists of mucopolysaccharide (or slime-like) structures produced by microorganisms as a defense mechanism against their environment. Encased in biofilm, bacteria can survive for prolonged periods by assuming a dormant state. When bacteria are in a dormant state, they are largely immune to antibiotics, which are generally only effective against bacteria during specific non-dormant stages in their life cycle. When bacteria are protected by biofilm, antibiotics frequently provide only temporary relief and bacteria can eventually emerge from their biofilm to re-infect the patient. In biofilm, bacteria are also largely protected from white blood cells that normally kill most pathogens that enter the body. White blood cells combat bacteria by engulfing them, which they are unable to do once bacteria have created biofilm. Furthermore, many commonly used antiseptics are neutralized by biofilm.



Antibiotic Resistance


Bacteria are becoming resistant to different classes of existing antibiotics at increasing rates. These increasing levels of resistance are principally the result of repeated exposure of bacteria to non-lethal quantities of antibiotics and the ability of certain bacteria to transmit mutant genes to other bacterial species, thus enabling different species of bacteria to survive the antibiotic to which the first species was exposed. The increase in antibiotic resistance since 1990 has been substantial and is especially prevalent in hospital environments. According to the State of Pennsylvania 2005 Report, 14% of hospital ICU infections were fatal and those infections accounted for $2.9 billion in increased costs.



NovaBay Publications


Published Articles


2011


Structure stability/activity relationships of sulfone stabilized
N,N- dichloroamines


Novel 3-chlorooxazolidin-2-ones as antimicrobial agents


Novel  N- chloroheterocyclic antimicrobials


Chemical Characterization and Biological Properties of NVC-422,
a Novel, Stable 
N- Chlorotaurine Analog


2009


N,N- Dichloroaminosulfonic acids as novel topical antimicrobial agents


Stieglitz rearrangement of  N,N- dichloro-β,β-disubstituted taurines under mild aqueous conditions


Quaternary ammonium  N , N -dichloroamines as topical, antimicrobial agents


2008


N- Chloro-2,2-dimethyltaurines: a new class of remarkably stable  N- chlorotaurines


2007


Hypochlorous Acid as a Potential Wound Care Agent



Posters


2011


American Chemical Society: N-Chlorooxazolidin-2-onesas Antimicrobial Agents at Neutral pH


American Chemical Society: Quaternary ammonium stabilized dichloroamines as antimicrobial agents


American Chemical Society: Sulfonyl-polyol N,N-dichloroamines with fast-acting, broad-spectrum antimicrobial activity


American Chemical Society: Towards the development of shelf-stable N-chloroamines as topical anti-microbial agents


Simon Foundation for Continenence - NVC-422 Prevents Urinary Catheter Blockage and Encrustation


Association for Research in Vision and Opthamology - Aganocide® Compounds Effective Against Ophthalmic Pathogens


Wound Healing Society - NeutroPhase® with Sorbact® Dramatically Enhances the Speed of Wound Healing


2010


American Chemical Society: New -Chloroamines: Chemical Synthesis, Solution Stability and Biological Activity


American Chemical Society: Water-soluble N-chloroheterocycles as topical antimicrobial agents


Association for Research in Vision and Opthamology - Topical Ophthalmic Agent


Interscience Conference on Antimicrobial Agents and Chemotherapy - Cath. Patency


Interscience Conference on Antimicrobial Agents and Chemotherapy - Anticoagulant


Interscience Conference on Antimicrobial Agents and Chemotherapy - Influenza


Interscience Conference on Antimicrobial Agents and Chemotherapy - Tissue Infection


Infectious Diseases Society of America - Impetigo


Infectious Diseases Society of America - Infected Nail


2009


American Chemical Society - Efficacy of NVC-422 / Biofilm


Interscience Conference on Antimicrobial Agents and Chemotherapy - Stabilized Derivatives of  N- Chlorotaurines


Interscience Conference on Antimicrobial Agents and Chemotherapy - Bactericidal Activity against Antiseptic and Antibiotic-Resistant Staphylococcus aureus Strains


Infectious Diseases Society of America -  In Vitro  Evaluation of Stable Derivatives of the Chlorotaurines on Infected Human Nail Model as Potent Antifungal Agents


2008


American Chemical Society - Stieglitz Rearrangement of  N , N -dichloro-β,β-disubstituted Taurines in Mild Aqueous Solution


American Chemical Society -  N , N -Dichloroamin



Relevant Articles


Impetigo


Emerging Infectious Diseases: NVC-422 topical gel for the treatment of Impetigo


Catheter-Associated Urinary Tract Infection


Novel Compound Found to Inhibit Biofilm Formation in Urinary Catheters (Including video)


Complicated Catheter-Associated Urinary Tract Infections Due to  Escherichia coli and  Proteus mirabilis


Why Are Foley Catheters So Vulnerable to Encrustation and Blockage by Crystalline Biofilm?


Drug-Resistant Bacteria


IJCEP: AgaDerm May be an Alternative to Bacitracin and Neomycin for Treating Skin Infections


Novel Infected Tissue Model for Pre-Clinical Evaluation of Antimicrobial Compounds (Including Video)


Compounds Do Double Duty as Antimicrobials and Anticoagulants (Including Video)


Drug-resistant infections Kill More Americans than AIDS and Breast Cancer Combined


World Health Organization Whitepaper on Antimicrobial Resistance


H1N1 Influenza


Aganocide Compounds Prove Effective against H1N1 Influenza Virus (Including Video)












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