ASTRAZENECA ANNOUNCES NON-EXECUTIVE BOARD CHANGES

17 February 2015 AstraZeneca today announced that Dr Cornelia (Cori) Bargmann will be proposed to shareholders for election as a Non-Executive Director at the Company's Annual General Meeting (AGM) on 24 April 2015.  On election, the Board also proposes appointing Dr Bargmann to AstraZeneca's Science Committee. Cori is the Torsten N. Wiesel Professor and head of the Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior at The Rockefeller University, New York, and a Howard Hughes Medical Institute investigator. John Varley, senior independent Non-Executive Director and Dame Nancy Rothwell, Non-Executive Director, both intend to retire from the Board at the close of the AGM on 24 April 2015, each having served as a Board member for nine years. John is currently Chairman of the Remuneration Committee and a member of the Nomination and Governance Committee.  Dame Nancy Rothwell is currently Chairman of the Science Committee, and a member of the Remuneration Committee and the Nomination and Governance Committee. As a result of the retirement of John Varley and Dame Nancy Rothwell, the following Board Committee changes will take place with effect from the close of the AstraZeneca 2015 AGM: ·  Rudy Markham will become senior independent Non-Executive Director. ·  Graham Chipchase will become Chairman of the Remuneration Committee and      a member of the Nomination and Governance Committee. ·  Bruce Burlington will become Chairman of the Science Committee and a member      of the Nomination and Governance Committee. ·  Geneviève Berger will oversee sustainability matters on behalf of the Board. In addition, Shriti Vadera will become a member of the Remuneration Committee with immediate effect. Leif Johansson, AstraZeneca Chairman, said: "John Varley and Dame Nancy Rothwell have been committed and hard-working Board members, serving the Company and its shareholders for the best part of a decade. I would like to pay tribute to their experience, wisdom, common sense and collegiality, as well as their leadership of the Remuneration Committee and the Science Committee respectively. I speak for all of my colleagues on the Board in saying that we will miss them and their contribution to our work; they go with our very best wishes for their future endeavours." "Their retirement has provided us with an opportunity to propose the appointment of new Board members. We welcomed Ann Cairns last year and are delighted that Cori Bargmann has agreed to join the Board in April. Cori will bring a wealth of experience in scientific research, fitting the needs of AstraZeneca's Board very well." All other current Directors will be presenting themselves for re-election at the AGM, in accordance with AstraZeneca's normal practice. In making the proposals and Board Committee appointments described above, the Board considered and satisfied itself as to the availability and time commitment of the Directors concerned. In relation to the proposed election of Cori Bargmann as a Non-Executive Director, there are no directorships to disclose under paragraph (1) and no disclosure obligations arise under paragraphs (2) to (6) of LR 9.6.13 R of the UK Listing Authority's Listing Rules. -ENDS- NOTES TO EDITORS Dr Cori Bargmann - biographical details Dr Cori Bargmann is the Torsten N. Wiesel Professor and head of the Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior at The Rockefeller University, New York.  She has been a Howard Hughes Medical Institute investigator since 1995.  She is a neurobiologist who studies the relationships between genes, neural circuits and behaviour using C. elegans, a tiny roundworm, as the model for her work.  Many of the genes and neural pathways in C. elegans are similar to those of mammals and their study provides an insight into the development and functioning of neural circuits. Cori holds a degree in biochemistry from the University of Georgia and a Ph.D. from the Massachusetts Institute of Technology, where she studied oncogenes with Robert Weinberg.  She pursued a postdoctoral fellowship with H. Robert Horvitz at MIT until 1991, when she accepted a faculty position in the Department of Anatomy at the University of California, San Francisco, spending 13 years there, latterly as Vice-Chair of the department.  She took up her current position at The Rockefeller University in 2004. Cori is the recipient of the 2015 Benjamin Franklin Medal in Life Science, one of nine individuals who will be presented with awards by The Franklin Institute, Philadelphia this year.  The award is for her contributions to neurobiology that have led to major discoveries elucidating the relationship between genes, neurons, neural circuits and behaviour. Membership of AstraZeneca Board Committees, with effect from the close of the AGM on 24 April 2015 Audit Committee Rudy Markham (Chairman of the Committee) Bruce Burlington Ann Cairns Jean-Philippe Courtois Shriti Vadera Remuneration Committee Graham Chipchase (Chairman of the Committee) Leif Johansson Rudy Markham Shriti Vadera Nomination and Governance Committee Leif Johansson (Chairman of the Committee) Bruce Burlington Graham Chipchase Rudy Markham Science Committee Bruce Burlington (Chairman of the Committee) Cori Bargmann Geneviève Berger Marcus Wallenberg About AstraZeneca AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of cardiovascular, metabolic, respiratory, inflammation, autoimmune, oncology, infection and neuroscience diseases. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information please visit: www.astrazeneca.com CONTACTS Media Enquiries Esra Erkal-Paler  +44 20 7604 8030 (UK/Global) Vanessa Rhodes  +44 20 7604 8037 (UK/Global) Ayesha Bharmal  +44 20 7604 8034 (UK/Global) Jacob Lund  +46 8 553 260 20 (Sweden) Michele Meixell  + 1 302 885 6351 (US) Investor Enquiries Thomas Kudsk Larsen  +44 20 7604 8199 mob: +44 7818 524185 Karl Hård  +44 20 7604 8123 mob: +44 7789 654364 Eugenia Litz   +44 20 7604 8233 mob: +44 7884 735627 Craig Marks  +44 20 7604 8591 mob: +44 7881 615764 Christer Gruvris  +44 20 7604 8126 mob: +44 7827 836825