Research Notes PPCH (.0048) >>>>>>>>>>>>>> Pro
Post# of 579
Posted On: 01/11/2015 12:07:52 PM
Research Notes PPCH (.0048) >>>>>>>>>>>>>>
Propanc Health Group Corporation
PPCH
Share Structure
Market Value $387,487 a/o Jan 09, 2015
Shares Outstanding 82,444,100 a/o Oct 14, 2014
Float Not Available
Authorized Shares Not Available
Par Value 0.001
Contact Info
• Level 13, Suite 1307
• 530 Collins Street
• Melbourne, VIC 3000
• Australia
• Website: http://www.propanc.com
• Phone: 61 03 9614 2795
• Email: info@propanc.com
Business Description
Propanc Health Group Corporation is a development stage healthcare company whose current focus is the development of new cancer treatments for patients with solid tumors such as pancreatic and colorectal cancer. Propanc was established in 2007 and located in Melbourne, Australia.
Financial Reporting/Disclosure
Reporting Status U.S. Reporting: SEC Filer
Audited Financials Audited
Latest Report Sep 30, 2014 10-Q
CIK 0001517681
Fiscal Year End 12/31
OTC Marketplace OTC Pink Current
Profile Data
SIC - Industry Classification 2834 - Pharmaceutical preparations
Incorporated In: DE, USA
Year of Inc. 2007
Employees Not Available
Company Officers/Contacts
James Nathanielsz
Service Providers
Accounting/Auditing Firm
Not Available
Legal Counsel
Szaferman Lakind Blumstein & Blader, PC
101 Grovers Mill Road
Suite 200
Lawrenceville, NJ, 08648
United States
Investor Relations Firm
Consulting for Strategic Growth 1, Ltd.
880 Third Ave.
6th Floor
New York, NY, 10022
United States
Network 1 Financial Securities
The Galleria Building, 2 Bridge Avenue
4th Floor
Red Bank, NJ, 07701
United States
Regal Consulting LLC
12533 El Camino Real
Unit E
San Diego, CA, 92130
United States
Propanc Health Group Targets Cancer Patient Trials in 2015
MELBOURNE, Australia, May 16, 2014 (GLOBE NEWSWIRE) -- Propanc Health Group Corporation (OTCQB
PCH) ("Propanc Health Group," "Propanc" or "the Company"
, a developmental stage a healthcare company focused on new cancer treatments for patients with solid tumors, today announced its key strategic objectives for the development of its lead product, PRP. This Company is now refocusing the preferred route of administration to intravenous (I.V.) injection. They are now targeting 2015 to prepare for and initiate human trials in patients with advanced colorectal and/or pancreatic cancers.
Dr Kenyon, Chief Scientific Officer of Propanc Health Group, states, "After a detailed strategic review of our scientific and preclinical research, our development team determined I.V. injection as the preferred route of administration. This approach would be the best way to maximise results in future patient trials, by ensuring maximum exposure of the drug to the tumor site."
James Nathanielsz, Chief Executive Officer of Propanc Health Group, said, "We believe this will help us to improve the results already observed in a Compassionate Use Study conducted by Dr Kenyon at the Dove Clinic (UK). We were able to extend life in a number of terminally ill patients, free from the serious side effects normally observed during conventional treatment methods."
Based on the Company's strategic review, Propanc Health Group will conduct a number of animal studies in various tumor models. This will identify a target dose for future patient trials. "Once we have assessed and identified the most effective dose in animals, we plan to meet with the FDA (Food and Drug Administration), to discuss and agree upon the planned formal preclinical program to support an Investigational New Drug Application (IND) to commence human trials in 2015," said Professor Klaus Kutz, Chief Medical Officer at Propanc Health Group. "Depending on the final indication selected for our initial patient trials, we may also seek Orphan Drug Designation for our treatment given the novelty of our proenzyme formulation and depending on the size of the target patient population we propose for trials."
The Company is seeking to complete the relevant animal studies and undertake preparation for patient trials next year. "Undertaking these development activities is a critical step for our future plans for the Company," James Nathanielsz, CEO of Propanc Health Group acknowledged. "Our attention will now turn toward raising the capital needed to complete these activities."
Propanc Health Group aims to fast-track the development of proenzyme-related oncology products into clinical trials, initially for colorectal and pancreatic tumors. The world market for colorectal cancer is expected to reach $8.8 billion by 2020 and the global pancreatic cancer market is projected to exceed $1.2 billion by the year 2015, according to Global Analyst Reports.
About Propanc Health Group Corporation
Propanc Health Group Corporation is a development stage healthcare company whose current focus is the development of new cancer treatments for patients with solid tumors such as pancreatic and colorectal cancer. Propanc, together with its scientific and oncology consultants, has developed a rational, composite formulation of anti-cancer compounds which together exert a number of anti-cancer actions. Propanc's leading products are novel, patented formulations based on proenzymes, which are inactive precursors of enzymes. As a result of positive early indications of the anti-cancer effects, Propanc intends to progress their lead product along the rigorous, formal non-clinical and clinical development pathway required to obtain regulatory approval to market its proenzyme formulation. Propanc intends to undertake development of manufacturing, formal non-clinical studies and then Phase I, II and III clinical trials in order to generate the quality, safety and efficacy data required for regulatory approval. For more information, please visit: www.propanc.com.
Forward-looking Statements:
Certain of the matters discussed in this announcement contain forward-looking statements that involve material risks to and uncertainties in the company's business that may cause actual results to differ materially from those anticipated by the statements made herein. Such risks and uncertainties include, among other things, our ability to establish and maintain the proprietary nature of our technology through the patent process, as well as our ability to possibly license from others patents and patent applications necessary to develop products; the availability of financing; the company's ability to implement its long range business plan for various applications of its technology; the company's ability to enter into agreements with any necessary marketing and/or distribution partners; the impact of competition, the obtaining and maintenance of any necessary regulatory clearances applicable to applications of the company's technology; and management of growth and other risks and uncertainties that may be detailed from time to time in the company's reports filed with the Securities and Exchange Commission. This is not a solicitation to buy or sell securities and does not purport to be an analysis of the company's financial position. See the company's most recent Quarterly Report on Form 10-Q and related 8K filings.
CONTACT: Propanc Health Group Corporation
James Nathanielsz, Chief Executive Officer
Tel: +61-039208-4182
Email: info@propanc.com
Web: www.propanc.com
Source: GlobeNewswire (May 16, 2014 - 4:00 PM EDT)
News by QuoteMedia
www.quotemedia.com
Propanc enters into $5 million Equity Purchase Agreement with Southridge Partners
MELBOURNE, Australia, Sept. 22, 2014 /PRNewswire/ -- Propanc Health Group Corporation (OTCQB: PPCH) ("Propanc" or "the Company" , an emerging healthcare company that focuses on the development of new and proprietary treatments for cancer patients, is pleased to announce it has executed an equity purchase agreement (the "EPA" with Southridge Partners II, L.P., an institutional investor, in the amount of $5 million, which will create significant growth capital for Propanc, enabling the execution of its business plan, on favorable terms.
Under terms of the EPA, Propanc has the right, but not the obligation to sell, from time to time, up to $5 million of its common stock to Southridge by submitting a "Draw Down" notice in an amount that the company determines. In order to draw down on the EPA, Propanc will need to file and register an S-1 registration statement with the Securities and Exchange Commission.
"We are pleased to be partnering with Southridge, an institutional investor with a long, reliable history of providing capital to the small cap space. We believe this capital will be sufficient to fund our growth strategy, enabling us to progress our product candidates through preclinical development and into clinical trials," said James Nathanielsz, Propanc's Chief Executive Officer. "The terms of this agreement are favorable to our shareholders and provide Propanc with the best opportunity to execute its business plan and deliver long-term shareholder value. We are grateful for the confidence Southridge has shown in Propanc, our management team, and our strategy."
"Propanc's business plan provided us with the confidence necessary to provide growth capital. We are excited to partner with Propanc and its seasoned management team as they execute their strategy," commented Stephen Hicks, Principal and CEO of Southridge Partners II, L.P.
About Southridge
Southridge is a diversified financial holding company specializing in direct investment and advisory services to small and middle market companies. Since 1996, the structured finance team has made direct investment of over $1.7 billion into growth companies worldwide. Southridge's expertise lies in an ability to customize a financing plan for the prospective client and then to execute on that plan without failing.
About Propanc:
We are a development stage healthcare company that is currently focused on developing new cancer treatments for patients suffering from pancreatic and colorectal cancer. Together with our scientific and oncology consultants, we have developed a rational, composite formulation of anti-cancer compounds, which together exert a number of effects designed to control or prevent tumors from recurring and spreading throughout the body. Our leading products are variations upon our novel formulation and involve or employ pro-enzymes, which are inactive precursors of enzymes. As a result of positive early indications of the anti-cancer effects of our technology, we intend to submit our pro-enzyme treatment to the rigorous, formal non-clinical and clinical development and trial processes required to obtain the regulatory approval necessary to commercialize it and any product(s) derived and/or to be derived therefrom.
In the near term, we intend to target patients with limited remaining therapeutic options for the treatment of solid tumors such as colorectal or pancreatic tumors. In the future, we intend to development our lead product to treat (i) early stage cancer and (ii) pre-cancerous diseases and (iii) as a preventative measure for patients at risk of developing cancer based on genetic screening. For more information, please visit: www.propanc.com.
Forward-looking Statements:
Certain of the matters discussed in this announcement involve risks and uncertainties including, without limitation, those regarding the Company's ability to establish and maintain the proprietary nature of its technology through the patent process, its ability to license from others patents and patent applications, if necessary, to develop certain products, its ability to implement its long range business plan for various applications of its technology, and its ability to enter into agreements with any necessary marketing and/or distribution partners for purposes of commercialization. This is not a solicitation to buy or sell securities and does not purport to be an analysis of the company's financial position. See Propanc's most recent Quarterly Report on Form 10-Q and related 8K filings.
SOURCE Propanc Health Group Corporation
Source: PR Newswire (September 22, 2014 - 4:01 PM EDT)
News by QuoteMedia
www.quotemedia.com
Bio-Tech Company with Groundbreaking Technology; Propanc Health Group Has Unique Anti-Metastasic Drug
M2 Communications "M2 PressWIRE"
Friday, January 09 2015 6:36 AM, EST
Propanc Health Group Corp. , a biopharmaceutical company organized in Melbourne, Australia , in 2007, has developed a unique drug for the treatment of many types of cancer specifically targeting the process of metastasis. Targeted therapies for metastatic cancer has long been regarded as an important goal in cancer research, as metastasis is the cause of most cancer-related deaths and as no currently approved cancer therapies target metastasis.
Most types of cancer - specifically those that initially arise as solid tumors - develop over long periods of time, remaining non-malignant or at least relatively treatable if identified at this early stage. Cancer becomes far more serious and difficult to treat when it spreads to new locations within the body. This process, called metastasis, is dangerous for a number of reasons. For one, it leads to the establishment of tumors in organs where simple surgical removal may not be possible. Tumors that begin in the skin, for example, can be easily removed if caught early, but metastases that end up in the lungs or the brain or anywhere near a large blood vessel can be dangerous to approach surgically.
Even more importantly, once a tumor has been found to spread to one site, it has very likely spread to many sites already. In these cases, simple surgical removal of one of the metastatic tumor is not nearly enough to deal with the spread. And metastatic tumors are often difficult to define clearly - tumors that start out as well-defined lumps are often diffuse and deeply integrated into the tissue when they are metastatic, again making them hard to approach surgically.
Finally, metastatic tumors have other qualities that make them more dangerous than primary tumors. Tumors that arise in skin, for example, maintain some of the qualities of skin cells for a time, but if they progress toward metastasis, they have typically acquired the qualities of the less well defined cells that normally live in places below the skin or below the surfaces of organs called mesenchymal cells. This transition from the qualities of epithelial (skin-like) cells to mesenchymal cells, also referred to as an epithelial to mesenchymal transition (EMT), has long been recognized as a general feature of the development of many types of cancer. Scientists have documented characteristic changes in the surfaces of these cells that are associated with the epithelial to mesenchymal transition, which includes the loss of a protein that normally allows these cells to stick tightly together, as in skin. This molecule, called E-cadherin, is a normal part of all skin cells and many other cell types that line the surfaces of organs.
Propanc has developed a blend of naturally-occurring chemicals - PRP - that has now been shown to specifically block or reverse the processes that lead to the development of metastases and their ability to grow and spread further. These chemicals, or proenzymes, are normally manufactured by the pancreas. In fact, the company name Propanc is derived from the words "proenzyme" and "pancreas". In tests on cancer cells, PRP was able to halt the growth of cancer cells and cause these cells to undergo cell death. It was also able to reverse the process of epithelial to mesenchymal transition, as indicated by specific changes in the proteins made by these cells, including the critical protein E-cadherin. Finally, PRP was also able to cause malignant cancer ce lls to transition to more harmless cell types, no longer cancerous. All three of these changes in cancer cells caused by PRP indicate that PRP may be highly effective in the treatment of metastatic cancers of many types. The results of these studies have been published in the peer-reviewed scientific journal Cellular Oncology in July, 2013.
What makes these findings particularly important is that there are currently no FDA -approved drugs specifically targeting metastatic cancer, yet without metastasis, most cancers would not be serious or fatal. Most chemical and radiological therapies for cancer are nonspecific, targeting all growing cells and therefore limiting their usefulness due to the inherent toxicity to normal cells. The demand for more targeted and less toxic drugs that specifically target metastasis is therefore enormous. Propanc has tremendous potential to change this market upon approval of PRP. It not only specifically targets metastatic cancer cells and the process of metastasis, it is composed of chemicals naturall y occurring in the human body and therefore lacking intrinsic toxicity to humans. This means that PRP could be used in a very high dose range, as needed for maximum effectiveness. It would also be less likely to exhibit toxic interactions when used in combination with other drugs.
The anti-tumor action of PRP can also be enhanced through the use of adjuncts that further enhance the tumor-killing properties of PRP. The Propanc formulation PRP-DCM adds well-studied chemotherapeutic agents that help to starve tumors of oxygen and increase the rate at which they undergo cell death.
Propanc is a forward-looking company that seeks to answer the large and growing demand for affordable, accessible, and easy to administer anti-cancer therapies. Propanc has developed a targeted anticancer therapeutic with the potential to extend survival among those patients with more advanced forms of cancer involving metastasis; currently, there are no drugs approved for the targeting of metastatic cancer, placing Propanc in a strong position as the regulatory process moves forward.
As a sector of the anti-cancer market, drugs targeting metastasis have not yet matured, and investors are not yet aware of its central importance for cancer therapy and its growth potential. Therefore, Propanc is currently likely to be highly undervalued as an investment.
Similar Companies to Propanc Health Group Corp. ( PPCH ) that are listed on major exchanges include:
Pluristem Therapeutics Inc. is a clinical-stage biotechnology company using placental cells and a unique, proprietary, three-dimensional (3D) technology platform to develop cell therapies for a broad spectrum of diseases.
AEterna Zentaris Inc. is a specialty biopharmaceutical company engaged in developing and commercializing novel treatments in oncology, endocrinology and women's health. The Company's pipeline encompasses compounds at various stages of development.
CTI BioPharma Corp. is a biopharmaceutical company whose mission is to acquire, develop and bring to market less toxic, more effective therapies to treat and cure cancer.
About regalconsultingllc.com
RegalConsultingLLC.com is a leading independent research, advisory and consulting firm serving Investors, Publicly Traded Companies, Private Companies and The Financial Community .
Legal Disclaimer
Except for the historical information presented herein, matters discussed in this article contain forward-looking statements that are subject to certain risks and uncertainties that could cause actual results to differ materially from any future results, performance or achievements expressed or implied by such statements. Regal Consulting , www.RegalConsultingLLC.com is not registered with any financial or securities regulatory authority, and does not provide nor claims to provide investment advice or recommendations to readers of this release. Regal Consulting, LLC . which owns www.RegalConsultingLLC.com may from time to time have a position in the securities mentioned herein and may increase or decrease such positions without notice. For making specific investment decisions, readers should seek their own advice. Regal Consulting, LLC . which may be compensated for its services in the form of cash-based compensation or equity securities in the companies it writes about, or a combination of the two.
Media Contact
Company Name: RegalConsultingLLC.com
Contact Person: Media Relations
Email: RegalConsutlingLLC@gmail.com
Phone: 702-575-9157
Country: United States
Website: http://regalconsultingllc.com/
Propanc Health Group Corporation
PPCH
Share Structure
Market Value $387,487 a/o Jan 09, 2015
Shares Outstanding 82,444,100 a/o Oct 14, 2014
Float Not Available
Authorized Shares Not Available
Par Value 0.001
Contact Info
• Level 13, Suite 1307
• 530 Collins Street
• Melbourne, VIC 3000
• Australia
• Website: http://www.propanc.com
• Phone: 61 03 9614 2795
• Email: info@propanc.com
Business Description
Propanc Health Group Corporation is a development stage healthcare company whose current focus is the development of new cancer treatments for patients with solid tumors such as pancreatic and colorectal cancer. Propanc was established in 2007 and located in Melbourne, Australia.
Financial Reporting/Disclosure
Reporting Status U.S. Reporting: SEC Filer
Audited Financials Audited
Latest Report Sep 30, 2014 10-Q
CIK 0001517681
Fiscal Year End 12/31
OTC Marketplace OTC Pink Current
Profile Data
SIC - Industry Classification 2834 - Pharmaceutical preparations
Incorporated In: DE, USA
Year of Inc. 2007
Employees Not Available
Company Officers/Contacts
James Nathanielsz
Service Providers
Accounting/Auditing Firm
Not Available
Legal Counsel
Szaferman Lakind Blumstein & Blader, PC
101 Grovers Mill Road
Suite 200
Lawrenceville, NJ, 08648
United States
Investor Relations Firm
Consulting for Strategic Growth 1, Ltd.
880 Third Ave.
6th Floor
New York, NY, 10022
United States
Network 1 Financial Securities
The Galleria Building, 2 Bridge Avenue
4th Floor
Red Bank, NJ, 07701
United States
Regal Consulting LLC
12533 El Camino Real
Unit E
San Diego, CA, 92130
United States
Propanc Health Group Targets Cancer Patient Trials in 2015
MELBOURNE, Australia, May 16, 2014 (GLOBE NEWSWIRE) -- Propanc Health Group Corporation (OTCQB
PCH) ("Propanc Health Group," "Propanc" or "the Company" , a developmental stage a healthcare company focused on new cancer treatments for patients with solid tumors, today announced its key strategic objectives for the development of its lead product, PRP. This Company is now refocusing the preferred route of administration to intravenous (I.V.) injection. They are now targeting 2015 to prepare for and initiate human trials in patients with advanced colorectal and/or pancreatic cancers. Dr Kenyon, Chief Scientific Officer of Propanc Health Group, states, "After a detailed strategic review of our scientific and preclinical research, our development team determined I.V. injection as the preferred route of administration. This approach would be the best way to maximise results in future patient trials, by ensuring maximum exposure of the drug to the tumor site."
James Nathanielsz, Chief Executive Officer of Propanc Health Group, said, "We believe this will help us to improve the results already observed in a Compassionate Use Study conducted by Dr Kenyon at the Dove Clinic (UK). We were able to extend life in a number of terminally ill patients, free from the serious side effects normally observed during conventional treatment methods."
Based on the Company's strategic review, Propanc Health Group will conduct a number of animal studies in various tumor models. This will identify a target dose for future patient trials. "Once we have assessed and identified the most effective dose in animals, we plan to meet with the FDA (Food and Drug Administration), to discuss and agree upon the planned formal preclinical program to support an Investigational New Drug Application (IND) to commence human trials in 2015," said Professor Klaus Kutz, Chief Medical Officer at Propanc Health Group. "Depending on the final indication selected for our initial patient trials, we may also seek Orphan Drug Designation for our treatment given the novelty of our proenzyme formulation and depending on the size of the target patient population we propose for trials."
The Company is seeking to complete the relevant animal studies and undertake preparation for patient trials next year. "Undertaking these development activities is a critical step for our future plans for the Company," James Nathanielsz, CEO of Propanc Health Group acknowledged. "Our attention will now turn toward raising the capital needed to complete these activities."
Propanc Health Group aims to fast-track the development of proenzyme-related oncology products into clinical trials, initially for colorectal and pancreatic tumors. The world market for colorectal cancer is expected to reach $8.8 billion by 2020 and the global pancreatic cancer market is projected to exceed $1.2 billion by the year 2015, according to Global Analyst Reports.
About Propanc Health Group Corporation
Propanc Health Group Corporation is a development stage healthcare company whose current focus is the development of new cancer treatments for patients with solid tumors such as pancreatic and colorectal cancer. Propanc, together with its scientific and oncology consultants, has developed a rational, composite formulation of anti-cancer compounds which together exert a number of anti-cancer actions. Propanc's leading products are novel, patented formulations based on proenzymes, which are inactive precursors of enzymes. As a result of positive early indications of the anti-cancer effects, Propanc intends to progress their lead product along the rigorous, formal non-clinical and clinical development pathway required to obtain regulatory approval to market its proenzyme formulation. Propanc intends to undertake development of manufacturing, formal non-clinical studies and then Phase I, II and III clinical trials in order to generate the quality, safety and efficacy data required for regulatory approval. For more information, please visit: www.propanc.com.
Forward-looking Statements:
Certain of the matters discussed in this announcement contain forward-looking statements that involve material risks to and uncertainties in the company's business that may cause actual results to differ materially from those anticipated by the statements made herein. Such risks and uncertainties include, among other things, our ability to establish and maintain the proprietary nature of our technology through the patent process, as well as our ability to possibly license from others patents and patent applications necessary to develop products; the availability of financing; the company's ability to implement its long range business plan for various applications of its technology; the company's ability to enter into agreements with any necessary marketing and/or distribution partners; the impact of competition, the obtaining and maintenance of any necessary regulatory clearances applicable to applications of the company's technology; and management of growth and other risks and uncertainties that may be detailed from time to time in the company's reports filed with the Securities and Exchange Commission. This is not a solicitation to buy or sell securities and does not purport to be an analysis of the company's financial position. See the company's most recent Quarterly Report on Form 10-Q and related 8K filings.
CONTACT: Propanc Health Group Corporation
James Nathanielsz, Chief Executive Officer
Tel: +61-039208-4182
Email: info@propanc.com
Web: www.propanc.com
Source: GlobeNewswire (May 16, 2014 - 4:00 PM EDT)
News by QuoteMedia
www.quotemedia.com
Propanc enters into $5 million Equity Purchase Agreement with Southridge Partners
MELBOURNE, Australia, Sept. 22, 2014 /PRNewswire/ -- Propanc Health Group Corporation (OTCQB: PPCH) ("Propanc" or "the Company"
, an emerging healthcare company that focuses on the development of new and proprietary treatments for cancer patients, is pleased to announce it has executed an equity purchase agreement (the "EPA" with Southridge Partners II, L.P., an institutional investor, in the amount of $5 million, which will create significant growth capital for Propanc, enabling the execution of its business plan, on favorable terms. Under terms of the EPA, Propanc has the right, but not the obligation to sell, from time to time, up to $5 million of its common stock to Southridge by submitting a "Draw Down" notice in an amount that the company determines. In order to draw down on the EPA, Propanc will need to file and register an S-1 registration statement with the Securities and Exchange Commission.
"We are pleased to be partnering with Southridge, an institutional investor with a long, reliable history of providing capital to the small cap space. We believe this capital will be sufficient to fund our growth strategy, enabling us to progress our product candidates through preclinical development and into clinical trials," said James Nathanielsz, Propanc's Chief Executive Officer. "The terms of this agreement are favorable to our shareholders and provide Propanc with the best opportunity to execute its business plan and deliver long-term shareholder value. We are grateful for the confidence Southridge has shown in Propanc, our management team, and our strategy."
"Propanc's business plan provided us with the confidence necessary to provide growth capital. We are excited to partner with Propanc and its seasoned management team as they execute their strategy," commented Stephen Hicks, Principal and CEO of Southridge Partners II, L.P.
About Southridge
Southridge is a diversified financial holding company specializing in direct investment and advisory services to small and middle market companies. Since 1996, the structured finance team has made direct investment of over $1.7 billion into growth companies worldwide. Southridge's expertise lies in an ability to customize a financing plan for the prospective client and then to execute on that plan without failing.
About Propanc:
We are a development stage healthcare company that is currently focused on developing new cancer treatments for patients suffering from pancreatic and colorectal cancer. Together with our scientific and oncology consultants, we have developed a rational, composite formulation of anti-cancer compounds, which together exert a number of effects designed to control or prevent tumors from recurring and spreading throughout the body. Our leading products are variations upon our novel formulation and involve or employ pro-enzymes, which are inactive precursors of enzymes. As a result of positive early indications of the anti-cancer effects of our technology, we intend to submit our pro-enzyme treatment to the rigorous, formal non-clinical and clinical development and trial processes required to obtain the regulatory approval necessary to commercialize it and any product(s) derived and/or to be derived therefrom.
In the near term, we intend to target patients with limited remaining therapeutic options for the treatment of solid tumors such as colorectal or pancreatic tumors. In the future, we intend to development our lead product to treat (i) early stage cancer and (ii) pre-cancerous diseases and (iii) as a preventative measure for patients at risk of developing cancer based on genetic screening. For more information, please visit: www.propanc.com.
Forward-looking Statements:
Certain of the matters discussed in this announcement involve risks and uncertainties including, without limitation, those regarding the Company's ability to establish and maintain the proprietary nature of its technology through the patent process, its ability to license from others patents and patent applications, if necessary, to develop certain products, its ability to implement its long range business plan for various applications of its technology, and its ability to enter into agreements with any necessary marketing and/or distribution partners for purposes of commercialization. This is not a solicitation to buy or sell securities and does not purport to be an analysis of the company's financial position. See Propanc's most recent Quarterly Report on Form 10-Q and related 8K filings.
SOURCE Propanc Health Group Corporation
Source: PR Newswire (September 22, 2014 - 4:01 PM EDT)
News by QuoteMedia
www.quotemedia.com
Bio-Tech Company with Groundbreaking Technology; Propanc Health Group Has Unique Anti-Metastasic Drug
M2 Communications "M2 PressWIRE"
Friday, January 09 2015 6:36 AM, EST
Propanc Health Group Corp. , a biopharmaceutical company organized in Melbourne, Australia , in 2007, has developed a unique drug for the treatment of many types of cancer specifically targeting the process of metastasis. Targeted therapies for metastatic cancer has long been regarded as an important goal in cancer research, as metastasis is the cause of most cancer-related deaths and as no currently approved cancer therapies target metastasis.
Most types of cancer - specifically those that initially arise as solid tumors - develop over long periods of time, remaining non-malignant or at least relatively treatable if identified at this early stage. Cancer becomes far more serious and difficult to treat when it spreads to new locations within the body. This process, called metastasis, is dangerous for a number of reasons. For one, it leads to the establishment of tumors in organs where simple surgical removal may not be possible. Tumors that begin in the skin, for example, can be easily removed if caught early, but metastases that end up in the lungs or the brain or anywhere near a large blood vessel can be dangerous to approach surgically.
Even more importantly, once a tumor has been found to spread to one site, it has very likely spread to many sites already. In these cases, simple surgical removal of one of the metastatic tumor is not nearly enough to deal with the spread. And metastatic tumors are often difficult to define clearly - tumors that start out as well-defined lumps are often diffuse and deeply integrated into the tissue when they are metastatic, again making them hard to approach surgically.
Finally, metastatic tumors have other qualities that make them more dangerous than primary tumors. Tumors that arise in skin, for example, maintain some of the qualities of skin cells for a time, but if they progress toward metastasis, they have typically acquired the qualities of the less well defined cells that normally live in places below the skin or below the surfaces of organs called mesenchymal cells. This transition from the qualities of epithelial (skin-like) cells to mesenchymal cells, also referred to as an epithelial to mesenchymal transition (EMT), has long been recognized as a general feature of the development of many types of cancer. Scientists have documented characteristic changes in the surfaces of these cells that are associated with the epithelial to mesenchymal transition, which includes the loss of a protein that normally allows these cells to stick tightly together, as in skin. This molecule, called E-cadherin, is a normal part of all skin cells and many other cell types that line the surfaces of organs.
Propanc has developed a blend of naturally-occurring chemicals - PRP - that has now been shown to specifically block or reverse the processes that lead to the development of metastases and their ability to grow and spread further. These chemicals, or proenzymes, are normally manufactured by the pancreas. In fact, the company name Propanc is derived from the words "proenzyme" and "pancreas". In tests on cancer cells, PRP was able to halt the growth of cancer cells and cause these cells to undergo cell death. It was also able to reverse the process of epithelial to mesenchymal transition, as indicated by specific changes in the proteins made by these cells, including the critical protein E-cadherin. Finally, PRP was also able to cause malignant cancer ce lls to transition to more harmless cell types, no longer cancerous. All three of these changes in cancer cells caused by PRP indicate that PRP may be highly effective in the treatment of metastatic cancers of many types. The results of these studies have been published in the peer-reviewed scientific journal Cellular Oncology in July, 2013.
What makes these findings particularly important is that there are currently no FDA -approved drugs specifically targeting metastatic cancer, yet without metastasis, most cancers would not be serious or fatal. Most chemical and radiological therapies for cancer are nonspecific, targeting all growing cells and therefore limiting their usefulness due to the inherent toxicity to normal cells. The demand for more targeted and less toxic drugs that specifically target metastasis is therefore enormous. Propanc has tremendous potential to change this market upon approval of PRP. It not only specifically targets metastatic cancer cells and the process of metastasis, it is composed of chemicals naturall y occurring in the human body and therefore lacking intrinsic toxicity to humans. This means that PRP could be used in a very high dose range, as needed for maximum effectiveness. It would also be less likely to exhibit toxic interactions when used in combination with other drugs.
The anti-tumor action of PRP can also be enhanced through the use of adjuncts that further enhance the tumor-killing properties of PRP. The Propanc formulation PRP-DCM adds well-studied chemotherapeutic agents that help to starve tumors of oxygen and increase the rate at which they undergo cell death.
Propanc is a forward-looking company that seeks to answer the large and growing demand for affordable, accessible, and easy to administer anti-cancer therapies. Propanc has developed a targeted anticancer therapeutic with the potential to extend survival among those patients with more advanced forms of cancer involving metastasis; currently, there are no drugs approved for the targeting of metastatic cancer, placing Propanc in a strong position as the regulatory process moves forward.
As a sector of the anti-cancer market, drugs targeting metastasis have not yet matured, and investors are not yet aware of its central importance for cancer therapy and its growth potential. Therefore, Propanc is currently likely to be highly undervalued as an investment.
Similar Companies to Propanc Health Group Corp. ( PPCH ) that are listed on major exchanges include:
Pluristem Therapeutics Inc. is a clinical-stage biotechnology company using placental cells and a unique, proprietary, three-dimensional (3D) technology platform to develop cell therapies for a broad spectrum of diseases.
AEterna Zentaris Inc. is a specialty biopharmaceutical company engaged in developing and commercializing novel treatments in oncology, endocrinology and women's health. The Company's pipeline encompasses compounds at various stages of development.
CTI BioPharma Corp. is a biopharmaceutical company whose mission is to acquire, develop and bring to market less toxic, more effective therapies to treat and cure cancer.
About regalconsultingllc.com
RegalConsultingLLC.com is a leading independent research, advisory and consulting firm serving Investors, Publicly Traded Companies, Private Companies and The Financial Community .
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