New method to give Diamyd® will be tested in adults with

New Post Public Reply Private Reply Replies (0) Message Board

News Desk 2018

Sep 12, 2014 at 2:45 AM

New method to give Diamyd® will be tested in adults with type 1 diabetes

Diamyd Medical (NASDAQ OMX First North, Ticker: DMYD B) informs that a new way to give Diamyd® will be tested in a clinical study with five adults newly diagnosed with type 1 diabetes. The investigator initiated study has been approved by the Swedish MPA. In analogy to the development in allergy therapy, where the administration of allergen into lymph nodes has significantly improved the efficacy, Diamyd® will in this study be administered directly into lymph nodes in combination with treatment with vitamin D. “This is an innovative approach that may become important both for the treatment of type 1 diabetes as well as other autoimmune diseases,” says Professor Johnny Ludvigsson at Linköping University, principal investigator of the study. “We have previously shown that Diamyd® has some effect in terms of preservation of the insulin producing beta cells and now we are trying different ways to enhance this effect. Direct intralymphatic administration is one such way. Combination regimens with potentially effective molecules that fight the disease from other angles is another way. Just as in cancer therapy, different combination regimens must be tested to arrive at a cure of autoimmune diabetes.” Diamyd® is an Antigen Based Therapy (ABT) developed for the treatment and prevention of type 1 diabetes. The active ingredient is the autoantigen GAD. Diamyd® has shown an overall 16% efficacy (p = 0.10) in a European Phase III study and is intended to be included as a component in combination therapies for the disease. “Diamyd® is today the furthest developed ABT for the treatment and prevention of type 1 diabetes,” says Anders Essen-Möller, Chairman of Diamyd Medical. “We have identified several approved drugs that we believe act synergistically with our ABT. A clinical study with Diamyd® in combination with ibuprofen and vitamin D is ongoing and several others are being prepared.” The new study, DIAGNODE, is an open label pilot study with five patients between 18 and 30 years of age who have been diagnosed with type 1 diabetes within 6 months. An initial evaluation will be made after 6 months, with a focus on safety and immunological markers, and the patients will thereafter be followed for another 24 months. All five participants will receive a low dose (4μg) of Diamyd® in the lymph node on three occasions. Diamyd® is in this study combined with a high dose of vitamin D. The vitamin D is provided in order to down regulate the immune system’s inflammatory components to thereby increase the ABT's tolerance inducing effect in regard of preserving the patient's insulin producing capacity. About type 1 diabetes Type 1 diabetes is an autoimmune disease where the immune system attacks the patients’ own insulin producing beta cells. For these patients, daily treatment with insulin is mandatory to sustain life. The importance of finding a cure is high for the world’s health care systems and the wellbeing of patients. The annual market for an easy to use, successful therapeutic is estimated to several billion dollars. About Diamyd® Diamyd® is a therapeutic under development for the treatment and prevention of autoimmune diabetes. Diamyd® has been used in trials totaling more than one thousand patients with an excellent safety profile. Diamyd has shown an overall 16% efficacy (p=0.1) versus placebo regarding preservation of the patients’ endogenous insulin secretion in a European Phase III trial and is currently being further developed in combination regimens with other therapeutic compounds. Diamyd® is easy to administer in any clinical setting. For further information, please contact: Anders Essen-Möller, Chairman Diamyd Medical AB Phone: +46 70 55 10 679. E-mail: anders.essen-moller@diamyd.com About Diamyd Medical Diamyd Medical is dedicated to fight type 1 diabetes and to work towards a cure for the disease. Diamyd Medical’s current projects include development of combination regimens for arresting the successive destruction of insulin producing beta cells using the Company’s GAD65-based diabetes vaccine Diamyd®, such as Diamyd®+ Vitamin D with or without an anti-inflammatory compound; and Diamyd®+ GABA, for which Diamyd Medical licenses exclusive intellectual rights from the University of California in Los Angeles (UCLA). Diamyd Medical has further acquired 46% of the stem cell company Cellaviva AB that is establishing a Swedish commercial bank for private family saving of umbilical cord blood and other sources of stem cells. Stem cells are required for Personalized Regenerative Medicine (PRM), for example to restore beta cell mass in diabetes patients where autoimmunity has been arrested. Remium Nordic AB is the Company’s Certified Adviser. Diamyd Medical AB (publ) Kungsgatan 29, SE-111 56 Stockholm, Sweden. Phone: +46 8 661 00 26, Fax: +46 8 661 63 68 E-mail: info@diamyd.com. Reg. no.: 556242-3797. Website: www.diamyd.com.

Newer

Older

Scroll down for more posts ▼

Top 10 Most Recent News Articles

Biointron's RushDATA™: Speeding Up Antibody Discovery

A New Chapter in Antibody Discovery Well, color me intrigued. Biointron, a name you'd recognize if you've got even a toe in the biotech pond, just threw a serious curveball into the antibody discovery game with RushDATA™—an AI- and machine learning-driven platform that's packing a punch. And it's not just about throwing tech buzzwords around; this thing clocks...

First Horizon's $25M Bet: New Center Transforms Houston

New Markets Tax Credits: A Game Changer First things first, if you're thinking this is some typical charitable write-off, think again. First Horizon Bank (NYSE: FHN) is deep in the mix of something pretty transformative in the world of finance and community support. They're not just throwing money at a problem and hoping it sticks. Nope, we're talking real strategy with a...

When to Switch Your LLC to S Corp Status: Tips

Is Your LLC Ready for the S Corp Leap? Thinking about shifting your LLC to S corporation status? You're not alone—many business owners hit this fork in the road as their enterprise starts rolling in more dough. And if you're scratching your head wondering if this switch makes sense for your venture, listen up because timing and context are everything here. When Should...

Will Hair Loss Drugs Challenge Transplant Clinics?

Emerging Treatments Stir Up Hair Loss Scene You ever get the feeling we're on the brink of something big? That's where we are with hair loss treatments, folks. As of late 2026, new drugs are making waves in clinical trials, but they’re not yet giving hair transplant clinics any sleepless nights. Smile Hair Clinic's co-founders, Dr. Mehmet Erdo?an and Dr. Gökay Bilgin,...

SPOC Energy's Hiring Push Signals Growth Surge

A Growing Workforce for a Growing Demand Here we are, smack dab in a bustling week of business news, and among it, SPOC Energy is ramping up its workforce across Alabama. Now, SPOC isn't any run-of-the-mill operation; this Birmingham-based manufacturer messes around with advanced power conversion systems and motor-control automation—a mouthful, sure, but critical stuff...

Foreigner to Rock Irvine with Night Ranger in 2027

Irvine Set for a Rock Revival Talk about a blast from the past! On March 27, 2027, two titans of the rock world, Foreigner and Night Ranger, are set to ignite Irvine like it's the glory days of arena rock all over again. Hosted at the Great Park Live, this show isn't just a concert—it's a full-scale invasion of rock's golden age right into Southern California's heart....

Philip Scroggie's Legacy in Global Energy Projects

A Lifetime of Energy Industry Excellence When you've been around the block in the energy sector as long as Philip D. Scroggie has, you're bound to pick up a few accolades. Recognized as an Inner Circle Lifetime Member, this guy has etched his name in the annals of global energy project management. Yeah, he's been a heavyweight in the oil, gas, and LNG industries, and he's...

TruGreen Finds New Growth in Birch Hill Acquisition

TruGreen's New Chapter Begins In the world of lawn care, TruGreen is sowing the seeds for a revitalized future, courtesy of its recent acquisition by Birch Hill Equity Partners. Based out of Franklin, Tennessee, this powerhouse in the green arena is set to start a fresh chapter, swapping partners like old gloves after a long, 19-year stint with Clayton, Dubilier & Rice...

The Melt Expands with Key Texas Franchise Deal

Throwing Down the Gauntlet: The Melt Expands If there's one thing I've learned after decades watching these restaurant chains multiply like rabbits it’s this: when a veteran gets involved, you perk up. The Melt has done just that by roping in Syed Ahmad—a name that actually means something in this game—to open eight new locations in the Lone Star State. It isn't...

ADI Global Faces Investor Investigation Over Major Write-Down

Towering Goodwill Falls and Investor Scrutiny Well, let's dig into this mess ADI Global Distribution has found itself in. If you were hanging onto ADIG shares, your portfolio probably took quite the hit when they revealed a nasty $659 million goodwill write-down. Imagine opening up those financials and seeing about 62% of goodwill value wiped out overnight. Suddenly, that...