PPHM Alerts 08/11/2014 21:52:59 $PPHM
Guess we will find out in approx 60 days if they applied and subsequently approved
Hey if they can fund one and partner the other that's fine with me. A little clarity on direction would be helpful to investors
Why not do both? But I agree, it's time we start getting some clear direction from management. Lock into a partnership or multiple partnerships and maybe we get better communication.
Where did the anti-PPHM crowd go? Ignore function doesn't block them all. You would think they would post something just to plead ignorance when the SEC boys come knocking.
good question on what this will do... or possibly do... to the Phase III lung.
I think that the DMC members live and die on statistics and probabilities and use "ALL" information at hand in any problem. Their current problem.... is sitting on the SunrRise Phase III trial of Peregrines and "if" new inputs are available to them to help them make their decision, then I'm certain they must use all available data.
IF during a clinical trial they find that all persons that pass on ... are all of a sudden found to have a "specific" DNA trait... then they may stop the trial because now the trial may be enrolling patients that are put at risk.
IF the DMC find new information regarding MDSC's or some other form of blood test that proves their immune system is performing optimally and they all happen to be on the Bavi arm of the trial.... ??
Well... I think they can stock the trial right at this point.
Peregrine just may see some intercept type (market cap) price spikes
Fingers crossed.
Wish I knew,
From my conversation last spring heard about biomarkers in liver and melanoma but was told that the lung trial was a straight one without them. Now that was last March and in this spinning world things seem to be changing quite rapidly.
What will this do to lung?
Quote:
now you need to think whether you move forward with that combo or advance the recent anti pd1 preclinical to phase I human trials
... with Pvalues of .004 that is 100% BTD from the FDA, which moves us right into Phase III
I'll agree with Sulaco... "Peregrine sitting in the cat bird seat.." is how I think he worded it
North.... I hope this means that my #1 hope of having CALICO involved with Peregrine is still alive ??
hmmm, maybe so after seeing that shade of green they used on their website.... looks awfully like that shade of green from Peregrines website lol : )
No, not serious about the green shade.... but after seeing green grass grow faster than Peregrines news cycle, one can get anxious
Big Pharma more anxious though and they don't like seeing all these combos coming out, especially with Pvalues of .004
My math friends who I told about Peregrine many months ago seen this today to call and say this is getting interesting now
Math is universal and they see a big, bright future in Tustin, CA
Big Pharma has hid behind Pvalues for many years... and now, its Pvalues that will unleash Peregrine as the top dog
We have phase II with taxane chemo in breast now you need to think whether you move forward with that combo or advance the recent anti pd1 preclinical to phase I human trials. Need better direction from leadership.
SW...you know THEY will try.....PG missed it.....DAD GUM!!!!
Send in PM.....
I'm all the place and really need to catch up on PPHMs' interesting news.
sheesh...where's my wookie copier...I need another one of me! LOL (NOT) 'sigh' yawn.....zzzzzzzzzz
wook
You know I was joking right dude?
Congrats brother porkchop!!!!! Bring the ship around.....I need a ride to the SS Thorpe......time to start prepping the ship.....Again......PPHM may be about to fuel her up with some serious hopium!!!!!
The trend will be our friend again.....just a month and half late. : ) imho
wook
Great PPHM can't even buy their own shares, how amusing lolz
That bodes well for your Kyoto projection IMO.
Here's some biomarkers from pr...
Quote:
Also, the once weekly combination treatment with ch1N11 and anti-PD-1 led to a 78% and 81% increase in intratumoral CD4+ and CD8+ T cells, two key indicators that show that tumor fighting immune cells are present in the local tumor environment, compared to the single agent anti-PD-1.
Local environment.
Got me another 1k today, early.
Imo.
porkchop11 :0
I'd agree with that theory... maybe MDSC's are being used and the level of MDSC's or evene white blood cells or some form of leukocytes..etc are being used to compare the ones that are complete responses vs those immune systems that may not have been helped by the Bavi/PS Targeting arm...
If so... hopefully that blood test is just about ready to be used in conjunction with possibly any type of scans the insurance companies may require...
in time... blood tests will most likely be all that is required
time will tell
"WARRANT AN EXPANDED CLINICAL INVESTIGATION IN BREAST CANCER..."
The writing's on the wall, folks. We've got a PIII running in lung CA, and now they're talking BREAST? These are the biggest cancers out there - and the COMPELLING PPHM data, which are stat sig, will NOT go unnoticed by the Big Boys.
Bristol or Merck, with their anti-PD-1 and anti-CTLA-4 babies, WILL most likely partner with PPHM.
They just HAVE to. They've already invested gazillions in these Mabs, and they don't work well without Bavi. Talk about gnashing of teeth....the data are provoking more and more BP angst.
Sooo thankful we didn't partner with Abbvie back in Sept. 2012.
Sitting right now in the cat. bird. seat.
Hopeful the BOD continues to do what they've been doing i.e. holding tight and sitting tight as this poker hand slowly but surely reveals itself.
GLTAL!
Joe
How about that with the new markers that they are using in this trial they are able to reach decisions earlier??
Isn't that the reason that we expect earlier results from the Melanoma trial??
Andy C.
Guess we will find out in approx 60 days if they applied and subsequently approved
Hey if they can fund one and partner the other that's fine with me. A little clarity on direction would be helpful to investors
Why not do both? But I agree, it's time we start getting some clear direction from management. Lock into a partnership or multiple partnerships and maybe we get better communication.
Where did the anti-PPHM crowd go? Ignore function doesn't block them all. You would think they would post something just to plead ignorance when the SEC boys come knocking.
good question on what this will do... or possibly do... to the Phase III lung.
I think that the DMC members live and die on statistics and probabilities and use "ALL" information at hand in any problem. Their current problem.... is sitting on the SunrRise Phase III trial of Peregrines and "if" new inputs are available to them to help them make their decision, then I'm certain they must use all available data.
IF during a clinical trial they find that all persons that pass on ... are all of a sudden found to have a "specific" DNA trait... then they may stop the trial because now the trial may be enrolling patients that are put at risk.
IF the DMC find new information regarding MDSC's or some other form of blood test that proves their immune system is performing optimally and they all happen to be on the Bavi arm of the trial.... ??
Well... I think they can stock the trial right at this point.
Peregrine just may see some intercept type (market cap) price spikes
Fingers crossed.
Wish I knew,
From my conversation last spring heard about biomarkers in liver and melanoma but was told that the lung trial was a straight one without them. Now that was last March and in this spinning world things seem to be changing quite rapidly.
What will this do to lung?
Quote:
now you need to think whether you move forward with that combo or advance the recent anti pd1 preclinical to phase I human trials
... with Pvalues of .004 that is 100% BTD from the FDA, which moves us right into Phase III
I'll agree with Sulaco... "Peregrine sitting in the cat bird seat.." is how I think he worded it
North.... I hope this means that my #1 hope of having CALICO involved with Peregrine is still alive ??
hmmm, maybe so after seeing that shade of green they used on their website.... looks awfully like that shade of green from Peregrines website lol : )
No, not serious about the green shade.... but after seeing green grass grow faster than Peregrines news cycle, one can get anxious
Big Pharma more anxious though and they don't like seeing all these combos coming out, especially with Pvalues of .004
My math friends who I told about Peregrine many months ago seen this today to call and say this is getting interesting now
Math is universal and they see a big, bright future in Tustin, CA
Big Pharma has hid behind Pvalues for many years... and now, its Pvalues that will unleash Peregrine as the top dog
We have phase II with taxane chemo in breast now you need to think whether you move forward with that combo or advance the recent anti pd1 preclinical to phase I human trials. Need better direction from leadership.
SW...you know THEY will try.....PG missed it.....DAD GUM!!!!
Send in PM.....
I'm all the place and really need to catch up on PPHMs' interesting news.
sheesh...where's my wookie copier...I need another one of me! LOL (NOT) 'sigh' yawn.....zzzzzzzzzz
wook
You know I was joking right dude?
Congrats brother porkchop!!!!! Bring the ship around.....I need a ride to the SS Thorpe......time to start prepping the ship.....Again......PPHM may be about to fuel her up with some serious hopium!!!!!
The trend will be our friend again.....just a month and half late. : ) imho
wook
Great PPHM can't even buy their own shares, how amusing lolz
That bodes well for your Kyoto projection IMO.
Here's some biomarkers from pr...
Quote:
Also, the once weekly combination treatment with ch1N11 and anti-PD-1 led to a 78% and 81% increase in intratumoral CD4+ and CD8+ T cells, two key indicators that show that tumor fighting immune cells are present in the local tumor environment, compared to the single agent anti-PD-1.
Local environment.
Got me another 1k today, early.
Imo.
porkchop11 :0
I'd agree with that theory... maybe MDSC's are being used and the level of MDSC's or evene white blood cells or some form of leukocytes..etc are being used to compare the ones that are complete responses vs those immune systems that may not have been helped by the Bavi/PS Targeting arm...
If so... hopefully that blood test is just about ready to be used in conjunction with possibly any type of scans the insurance companies may require...
in time... blood tests will most likely be all that is required
time will tell
"WARRANT AN EXPANDED CLINICAL INVESTIGATION IN BREAST CANCER..."
The writing's on the wall, folks. We've got a PIII running in lung CA, and now they're talking BREAST? These are the biggest cancers out there - and the COMPELLING PPHM data, which are stat sig, will NOT go unnoticed by the Big Boys.
Bristol or Merck, with their anti-PD-1 and anti-CTLA-4 babies, WILL most likely partner with PPHM.
They just HAVE to. They've already invested gazillions in these Mabs, and they don't work well without Bavi. Talk about gnashing of teeth....the data are provoking more and more BP angst.
Sooo thankful we didn't partner with Abbvie back in Sept. 2012.
Sitting right now in the cat. bird. seat.
Hopeful the BOD continues to do what they've been doing i.e. holding tight and sitting tight as this poker hand slowly but surely reveals itself.
GLTAL!
Joe
How about that with the new markers that they are using in this trial they are able to reach decisions earlier??
Isn't that the reason that we expect earlier results from the Melanoma trial??
Andy C.
