DS107G-01 - Successful Completion of Phase I Oral DGLA

New Post Public Reply Private Reply Replies (0) Message Board
News Desk 2018
DS107G-01 - Successful Completion of Phase I Oral DGLA Clinical Trial

DUBLIN, Ireland, July 30, 2014 (GLOBE NEWSWIRE) -- via PRWEB - Dignity Sciences Limited, a privately held biopharmaceutical company, today announced the successful completion of a Phase I trial with DS107G, an oral formulation of Dihomo Gamma Linolenic Acid (DGLA).

This study was a randomized, placebo-controlled, double-blind, single-ascending and multiple dose Phase I clinical trial to assess the safety, pharmacokinetics and effect of food on DS107G in healthy subjects.

The study confirmed the benign safety profile of DGLA following both single and multiple oral doses over 28 days, thereby achieving the trial's primary safety objective. In addition, orally administered DGLA distributed well to the skin resulting in high dermal bioavailability which has important clinical implications. It was found that free DGLA skin blister fluid concentrations were similar to plasma concentrations after about 8 days of repeated dosing.

Commenting on the results, Dignity Sciences said that given the importance of DGLA for healthy skin, the large increase in skin concentrations of DGLA and the safety profile observed, DS107G (oral DGLA) is a strong candidate for the treatment of inflammatory skin diseases. A topical DGLA formulation (DS107E) was recently reported to result in an overall dose response improvement in a Phase II Atopic Dermatitis clinical trial.

The detailed analysis of these clinically significant results supports progressing the compound into a Phase II trial.

About Dignity Sciences

Dignity Sciences, a privately held biopharmaceutical company, was established to discover and develop scientifically innovative healthcare solutions that improve the quality of life of people with diseases for which current therapies are unsatisfactory. Dignity Sciences is led by recognized experts in developing fatty acids, including their bioactive derivatives, for the treatment of human disease.

This article was originally distributed on PRWeb. For the original version including any supplementary images or video, visit http://www.prweb.com/releases/2014/07/prweb12051851.htm

Dignity Sciences Limited Mark O' Neill ACA +353 12933590

Scroll down for more posts ▼

Top 10 Most Recent News Articles

Sinopec's Catalyst Conference: Driving Global Innovation

Updated Category News Views 90

The Role of Catalysts in Modern Industry Swing by any bustling industrial hub, and you're likely to catch talk about catalysts—unsung heroes that make the machinery of modern industry run smoother, faster, and cleaner. Over in Tianjin, China, Sinopec just wrapped up its Second International Catalyst Customer Conference, which is less of a tongue-twister than it sounds....

Continue Reading
Canton Fair 2026: Tech and Tradition Transform Jewelry

Updated Category News Views 0

Tech-Savvy Elegance at Canton Fair Dive into the glitz and glamour of the jewelry zone at the 140th Canton Fair, where technology and craftsmanship are forging a new narrative for luxury accessories. This isn’t just your grandmother’s jewelry box we're talking about anymore. We’re witnessing the dawn of precious metal smart rings and dual-band smart watches that...

Continue Reading
Flagstar Faces Heat: 9.2% Stock Drop Spurs Probe

Updated Category News Views 0

Flagstar's Descent: What Led to the Stock Tumble? And here we go again with a big name in finance taking a hit right between the eyes. Flagstar Bank, under ticker NYSE:FLG, saw its shares plummet by over 9.2% on October 23, 2026. This isn't just a blip—it's a spill. The backdrop here is an eye-watering $12.9 billion loan book tied to rent-regulated apartment buildings....

Continue Reading
Nucor's Q3 2026 Earnings: Strong Growth Amid Steel Surge

Updated Category News Views 65

Nucor's Solid Third Quarter Performance Nucor Corporation is flexing its muscles, reporting a robust third quarter for 2026. With net earnings hitting $1.32 billion and a diluted earnings per share of $5.80, the steel giant has shown it can more than hold its ground in a competitive market. Compare that to last quarter's $1.16 billion - we're seeing serious momentum....

Continue Reading
Greenhouse and Planetarium Revamp Enrich Florida Southern

Updated Category News Views 38

A Celebration of Science and Heritage In an era where institutions are either scaling back or going digital, Florida Southern College is doubling down on its roots and looking skyward. On October 22, 2026, the campus buzzed with a celebration that would have done any investor in education and heritage proud—raising the Ben and Missy Albritton Citrus and Horticulture...

Continue Reading
Canton Fair: More Than Trade—A Cultural Exchange

Updated Category News Views 142

Why a Trade Fair Needs Lion Dances October 2026 marks a time when talking about a trade fair means diving headfirst into a whirlpool of global exchange and cultural tango we don’t often see in the West. Yeah, I'm looking at you, Canton Fair—a long-runner over in China that's managed to haul in the globe to not just showcase wares, but bring people together in a clash...

Continue Reading
Innventure Faces Legal Scrutiny Over DarkNX Debacle

Updated Category News Views 110

Innventure’s Market Tumult: Unraveling the Drama Talk about a mess. Innventure Inc. (NASDAQ: INV) investors are likely feeling a sting sharper than a bee that's lost its hive after a painful 55% stock crash back in August 2026. The culprit? A scuttled project involving a shadowy partner, DarkNX, and a lot of questions about who knew what and when. A Puzzling...

Continue Reading
Essential Oils Market Booms; Hits $29.52Bn by 2031

Updated Category News Views 41

Essential Oils: Aromatherapy's New Frontier and Pharma Ally What’s the deal with essential oils? Well, it seems they’re not just for your neighbor’s pricey diffuser anymore. According to some fresh numbers, we're staring down a market worth nearly $30 billion by 2031. And it ain't all incense and hippie stores fueling this beast — we're talking a serious expansion...

Continue Reading
Key Sewer Line Damage Signs Homeowners Often Ignore

Updated Category News Views 71

Spotting Trouble Beneath the Surface Now, when was the last time you eyeballed your home’s plumbing with more than a passing glance? Most folks don’t give their sewer lines two thoughts until something foul pops up. Plumbing expert Jessica Gerdeman from Heggemann, Inc. in Warrenton, Missouri, isn’t just blowing hot air when she points out the indicators of looming...

Continue Reading
Thanksgiving Relief: Alabama Firm Offers $200 Gift Cards

Updated Category News Views 125

A Firm's Gratitude with a Dash of Holiday Cheer It takes more than just legal prowess to make waves in a community. Tyler Mann Injury Law is stepping outside the courtroom to bring some warmth to Alabama families this Thanksgiving. They're hosting a giveaway that puts a little financial relief where it counts—at the Thanksgiving dinner table, straightening out the...

Continue Reading

Top 5 Most Recently Viewed Articles

Dr. Chitra Rajagopal Joins American Oncology Network Team

Updated Category News Views 186

Welcoming Dr. Chitra Rajagopal to the Oncology Team American Oncology Network (AON), known for its rapid growth in community-based oncology practices, proudly announces the addition of Dr. Chitra Rajagopal, an esteemed medical oncologist. Her presence enhances the physician care team at The Center for Cancer and Blood Disorders, where she will be treating patients in the...

Continue Reading
Positive Earnings Outlook for Rapid Micro Biosystems Ahead

Updated Category News Views 137

Earnings Forecast for Rapid Micro Biosystems Rapid Micro Biosystems (NASDAQ: RPID) is poised to reveal its quarterly earnings soon. Investors are eager to see if the company can meet or exceed analyst expectations, particularly as they await the announcement regarding an estimated earnings per share (EPS) of $-0.26. This figure serves as a benchmark, providing insight...

Continue Reading
AppLovin's Options Activity: Insights and Future Implications

Updated Category News Views 162

Understanding Recent Options Activity of AppLovin In the world of stocks and investments, intriguing signals often emerge, especially when deep-pocketed investors begin to take interest. Recently, AppLovin (NASDAQ: APP) has captured the attention of many with its unusual options activity, hinting at potential market movements that traders shouldn't overlook. A Surge in...

Continue Reading
Empowering Youth Against Corruption: ICAC's Landmark Program

Updated Category News Views 135

Empowering Youth Against Corruption: ICAC's Landmark Program The Hong Kong International Academy Against Corruption, in collaboration with key international partners, has successfully launched the first-ever regional capacity building program focused on engaging youth in anti-corruption efforts. This initiative is crucial for fostering a culture of integrity among young...

Continue Reading
Innovaderm Research Strengthens Team with Rheumatology Expert

Updated Category News Views 78

Innovaderm Research Expands into Rheumatology Innovaderm Research, recognized for its expertise in dermatology, is thrilled to announce an important new addition to its team. Dr. Juan Gabriel Ovalles Bonilla, MD, PhD, an accomplished and board-certified rheumatologist, will be joining Innovaderm. His extensive experience brings added strength to the company’s efforts...

Continue Reading