Initial labs will be qpcr and basic hematology - c

Initial labs will be qpcr and basic hematology - cbc to check for any alteration in blood count, liver panel to monitor for metabolic stress, kidney monitoring etc..as well as dose related calculations of drug half-life, activity of primary metabolites, secondary metabolites, how active drug is with first and second pass thru liver, what drug properties remain active after traveling thru liver once and then twice.Efficacy will not be early pr. Early prs will have to be concrete (lab test supported quantifiable measurements) re tolerance and toxicity as well as p53 activation.