Hi NotRichYet, Have not finished reading todays p

Hi NotRichYet,

Have not finished reading todays posts so perhaps this question has already been answered. They will check for p53 activation 7 hours after first does and 24 hours after first dose. This activation, evidenced by seeing p21 expression, will be confirmed on day one of dosing with each subject.

http://clinicaltrials.gov/ct2/show/NCT0166400...amp;rank=1

• Changes in the biomarker p21 in peripheral blood lymphocytes [ Time Frame: baseline and 7 hours ] [ Designated as safety issue: No ]
  
  For biomarker analysis, p21 expression, assayed by qPCR, in peripheral blood lymphocytes after Kevetrin administration.
  
  


• Changes in the biomarker p21 in peripheral blood lymphocytes [ Time Frame: baseline and 24 hours ] [ Designated as safety issue: No ]
  
  For biomarker analysis, p21 expression, assayed by qPCR, in peripheral blood lymphocytes after Kevetrin administration.