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Latest Anavex Life Sciences (AVXL) Headlines

Anavex: Research Report Reveals Cardioprotective Action of Sigma-1 Receptor Agonists
GlobeNewswire - Tue Mar 04, 6:33AM CST
Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB:AVXL) is encouraged by the findings of a research report published in the current issue of peer-reviewed scientific journal Life Sciences. Among its conclusions, the report reveals that sigma-1 receptor (S1R) agonists play an important role in the prevention, delay or reduction of heart disease. These findings correlate with the positive electrocardiogram (EKG) parameters in the successfully completed human clinical Phase 1 safety trial of ANAVEX 2-73, an orally available S1R agonist drug candidate developed to treat Alzheimer's through potential disease modification. ANAVEX 2-73 has also shown highly encouraging synergy with donepezil, the world's best-selling Alzheimer's drug, and a Phase 1b/2a clinical trial of this combination, ANAVEX PLUS, is planned for the first half of 2014.

Research Report Confirms Opportunity for Anavex Anti-Cancer and Neuropathic Pain Compounds
GlobeNewswire - Wed Feb 26, 7:42AM CST
Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB:AVXL) today announced that a research article in the current issue of peer-reviewed scientific journal Molecular Pain reveals a new opportunity for the Company's anti-cancer and neuropathic pain compounds. The article describes that sigma-1 receptor (S1R) modulation prevents neuropathic pain and mitochondrial abnormalities induced by the chemotherapy drug paclitaxel.

Anavex to Present at 16th Annual BIO CEO & Investor Conference
GlobeNewswire - Mon Feb 03, 6:27AM CST
Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB:AVXL) today announced that Christopher U. Missling, PhD, President and Chief Executive Officer, will be presenting at the 16th Annual BIO CEO & Investor Conference on Monday, February 10, 2014, at 1:00 p.m. ET in the Conrad Room. The conference will be held at the Waldorf-Astoria Hotel in New York, NY.

Sigma-1 receptor Implicated in Cell Survival of Rare Neurodegenerative Diseases - Expanding the Opportunity for Application of ANAVEX PLUS in Rare Diseases
GlobeNewswire - Thu Jan 23, 6:17AM CST
Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB:AVXL) today announced that a publication in the current issue of scientific journal Neuropathology potentially extends the opportunity for ANAVEX PLUS to additional neurodegenerative diseases beyond Alzheimer's.

Anavex Agreement With The Roskamp Institute to Advance the Clinical Development of ANAVEX PLUS
GlobeNewswire - Tue Jan 14, 4:15PM CST
Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB:AVXL) today announced that they have established an agreement with The Roskamp Institute for the clinical development of ANAVEX PLUS, a new combination drug of ANAVEX 2-73 and donepezil (Aricept(R)) for the treatment of Alzheimer's disease. This study will evaluate the safety, tolerability, pharmacokinetics, and possible clinical benefits of ANAVEX PLUS in Alzheimer's disease patients and other diseases associated with dementia and cognitive impairment.

Anavex CEO Invited to Present at Upcoming Investment Conferences
GlobeNewswire - Tue Jan 07, 7:11AM CST
Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB:AVXL) today announced that its President and Chief Executive Officer Christopher U. Missling, PhD, will participate in the 7 Annual OneMedForum: Investing in Healthcare 2014 ("OneMedForum") and the Noble Financial Capital Markets ("Noble") Tenth Annual Equity Conference.

Anavex Life Sciences Corp elects John Harrison to Scientific Advisory Board
M2 - Wed Dec 11, 4:18AM CST
Biopharmaceutical company Anavex Life Sciences Corp (OTC Markets:AVXL) revealed on Tuesday the election of John Harrison, PhD, to its Scientific Advisory Board.

Anavex Appoints Clinical Design Expert to Scientific Advisory Board
GlobeNewswire - Tue Dec 10, 7:10AM CST
Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB:AVXL) today announced the appointment of John Harrison, PhD, to its Scientific Advisory Board. Dr. Harrison is an internationally acknowledged specialist for design of human clinical outcome measurement in Alzheimer's disease and other cognitive impairments.

Market Research: Depression - Pipeline Review, H2 2013
M2 - Fri Dec 06, 3:43AM CST
Research and Markets (http://www.researchandmarkets.com/research/q2dd65/depression) has announced the addition of the "Depression - Pipeline Review, H2 2013" report to their offering. 'Depression - Pipeline Review, H2 2013', provides an overview of the indication's therapeutic pipeline. This report provides information on the therapeutic development for Depression, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Depression. Scope - A snapshot of the global therapeutic scenario for Depression. - A review of the Depression products under development by companies and universities/research institutes based on information derived from company and industry-specific sources. - Coverage of products based on various stages of development ranging from discovery till registration stages. - A feature on pipeline projects on the basis of monotherapy and combined therapeutics. - Coverage of the Depression pipeline on the basis of route of administration and molecule type. - Key discontinued pipeline projects. - Latest news and deals relating to the products. Companies Mentioned Bristol-Myers Squibb Company Johnson & Johnson Boehringer Ingelheim GmbH AstraZeneca PLC GlaxoSmithKline plc Daiichi Sankyo Company, Ltd Taisho Pharmaceutical Co., Ltd. Takeda Pharmaceutical Company Limited Neurocrine Biosciences, Inc. Aphios Corporation Eisai Co., Ltd. H Lundbeck A/S Mitsubishi Tanabe Pharma Corporation Pfizer Inc. Sigma-Tau S.p.A. Addex Pharmaceuticals FAES Farma SA Anavex Life Sciences Corp. Karo Bio KunWha Pharmaceutical Co., Ltd. Newron Pharmaceuticals S.p.A. M et P Pharma AG Angelini Group Domain Therapeutics For more information visit http://www.researchandmarkets.com/research/q2dd65/depression About Research and Markets Research and Markets is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

Anavex Life Sciences Corp hires Dr Michael Gold to Scientific Advisory Board
M2 - Wed Dec 04, 6:51AM CST
Biopharmaceutical company Anavex Life Sciences Corp (Other OTC:AVXL) revealed on Tuesday the election of Dr Michael Gold, MD as a member of its Scientific Advisory Board.

Anavex Appoints Alzheimer's Industry Leader to Scientific Advisory Board
PR Newswire - Tue Dec 03, 6:30AM CST
Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB: AVXL) today announced the appointment of Michael Gold, MD, as a member of its Scientific Advisory Board. Dr. Gold has over 20 years of experience in the clinical development of Alzheimer's and other central nervous system (CNS) drugs and currently serves as Vice President of the CNS practice at UCB, Inc., a global biopharmaceutical company. His background also includes leadership roles with GlaxoSmithKline (GSK), Johnson & Johnson (J&J) and Bristol-Myers Squibb (BMS).

Anavex Announces Expansion of Scientific Advisory Board
PR Newswire - Wed Nov 20, 6:30AM CST
Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB: AVXL) announced today the appointment of Dr. Ottavio Arancio, MD, PhD to the Company's Scientific Advisory Board. Dr. Arancio is a cellular neurobiologist who has pioneered the field of mechanisms of synaptic dysfunction in Alzheimer's disease. He is Associate Professor of Pathology and Cell Biology at the Columbia University Medical Center and The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University. Over the last 10 years, Dr. Arancio has raised more than $25 million in grant funding and published more than 100 peer-reviewed scientific papers.

Anavex Reports Predicted Clinical Effect for ANAVEX 2-73 in Computer Simulation Model of Alzheimer's Disease
PR Newswire - Mon Nov 18, 6:30AM CST
Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB: AVXL) presented new data from a study evaluating ANAVEX 2-73 in a computer simulation model of Alzheimer's disease (AD) limited to symptomatic effects, which was presented during a poster session at the CNS Summit 2013 on Saturday, November 16th, 2013 in Boca Raton, Florida.

Anavex Announces Positive Data for ANAVEX 2-73 in Alzheimer's Disease
PR Newswire - Tue Nov 12, 6:30AM CST
Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB: AVXL) is pleased to announce that new study data showed ANAVEX 2-73 to be effective in counteracting the progression of Alzheimer's disease under chronic treatment in a transgenic mouse model of Alzheimer's, named Tg2576. The new data was presented by Tangui Maurice, PhD, CNRS Research Director at the University of Montpellier and INSERM, at the Society for Neuroscience 2013 Annual Meeting, running November 9-13, 2013 in San Diego, California.

Anavex CEO to Present Clinical Prediction Data for ANAVEX 2-73 at CNS Summit 2013
PR Newswire - Thu Nov 07, 6:30AM CST
Anavex Life Sciences Corp. (OTCQB: AVXL) is pleased to announce that its President and Chief Executive Officer Christopher U. Missling, PhD, will be presenting new clinical predication data supporting its investigational compound, ANAVEX 2-73, as a potential therapeutic for the treatment of Alzheimer's disease. The data will be unveiled in a poster presentation at the CNS Summit 2013, which takes place November 14-17, 2013 in Boca Raton, Florida. The poster presentation was co-authored by Tangui Maurice, PhD, INSERM; Athan Spiros, In Silico BioSciences (ISB); Patrick Roberts, ISB and Oregon Health & Science University; and, Hugo Geerts, ISB and University of Pennsylvania.

Anavex reports ANAVEX 2-73 blocks Tau and Amyloid-Beta Proteins in a Preclinical Model of Alzheimer's Disease
PR Newswire - Mon Nov 04, 6:30AM CST
Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB: AVXL) announces that issue 38 (2013) of the international scientific journal Neuropsychopharmacology contains a report demonstrating that ANAVEX 2-73 dose-dependently blocks Tau and amyloid-beta ("amyloid") proteins and memory deficit in a mouse model of Alzheimer's disease (AD). A reduction in these two main hallmarks of Alzheimer's has the potential to stop, slow or reverse the disease. The report also suggests that, because it is targeting the mixed muscarinic and Sigma-1 receptors, ANAVEX 2-73 is able to achieve its effect further "upstream" in the Alzheimer's disease cascade. This compares to most other current AD clinical development compounds that are mainly downstream and single-targeted approaches, which might be limited by adverse effects. More interestingly, themixed muscarinic and Sigma-1 agonist ANAVEX 2-73 exhibited powerful effects despite its moderate affinity for these receptors, emphasizing its great advantage for potential therapy in Alzheimer's disease.

Anavex to Present Data for ANAVEX 2-73 at Society for Neuroscience 2013 Annual Meeting
PR Newswire - Tue Oct 29, 6:30AM CDT
Anavex Life Sciences Corp. (OTCQB: AVXL) today announced that Tangui Maurice, PhD, CNRS Research Director, Head of Team 2 'Endogenous Neuroprotection in Neurodegenerative Diseases', at the University of Montpellier and INSERM, will be presenting new data supporting the investigational compound ANAVEX 2-73 as a potential therapeutic for the treatment of Alzheimer's disease. The data will be presented in a poster presentation, co-authored by Valentine Lahmy, PharmD and Vanessa Villard, PhD, Amylgen, at the Society for Neuroscience 2013 Annual Meeting, which takes place November 9-13, 2013 in San Diego, California. Anavex is a clinical stage biopharmaceutical company engaged in the development of novel drug candidates for the treatment of Alzheimer's disease and other neurodegenerative disorders, as well as oncology therapeutics.

Anavex Encouraged by New Sigma-1 Receptor Study That May Explain Therapeutic Efficacy of ANAVEX 2-73 for Alzheimer's Disease
Marketwire - Tue Oct 22, 8:04AM CDT
Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB: AVXL) today announced that the current issue of the peer-reviewed scientific journal PLOS ONE explains that sigma-1 receptor (Sig-1R) activity is involved in cellular survival by regulating and stabilizing a key cell stress sensor. These findings may explain the therapeutic efficacy of Sig-1R agonists like ANAVEX 2-73 in Alzheimer's disease and other neurodegenerative disorders.

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