Sarepta Therapeutics, Inc. (SRPT)
Duchenne Muscular Dystrophy (DMD) is an X-linked rare degenerative neuromuscular disorder causing severe progressive muscle loss and premature death. One of the most common fatal genetic disorders, DMD affects approximately one in every 3,500 boys born worldwide.
A devastating and incurable muscle-wasting disease, DMD is associated with specific errors in the gene that codes for dystrophin, a protein that plays a key structural role in muscle fiber function.
Progressive muscle weakness in the lower limbs spreads to the arms, neck and other areas. Eventually, increasing difficulty in breathing due to respiratory muscle dysfunction requires ventilation support, and cardiac dysfunction can lead to heart failure. The condition is universally fatal, and death usually occurs before the age of 30.
SRPT reported positive data through Week 120 from Study 202, a Phase IIb open-label extension study of eteplirsen in patients with Duchenne muscular dystrophy (DMD).
According to SRPT , results through more than two years showed a continued stabilization of walking ability in eteplirsen-treated patients evaluable on the 6-minute walk test (6MWT), a well-accepted measure of ambulation and clinical function in DMD.
As previously reported, Study 202 met its primary endpoint of increased novel dystrophin as assessed by muscle biopsy at Week 48 and is now in the long-term extension phase in which patients continue to be followed for safety and clinical outcomes.
Through 120 weeks, SRPT's eteplirsen was well tolerated and there were no reported clinically significant treatment-related adverse events and no treatment-related serious adverse events
SRPT 's eteplirsen is designed to address the underlying cause of DMD by enabling the production of a functional dystrophin protein. Data from clinical studies of eteplirsen in DMD patients have demonstrated a broadly favorable safety and tolerability profile and restoration of dystrophin protein expression.
SRPT is focused on developing first-in-class RNA-based therapeutics to improve and save the lives of people affected by serious and life-threatening rare and infectious diseases.
More about Sarepta Therapeutics, Inc. (SRPT) at www.sarepta.com .
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Crown Equity Holdings Inc. (CRWE)
When it comes to online social networking, websites are commonly used. These websites are known as social sites. Social networking websites function like an online community of internet users. Depending on the website in question, many of these online community members share common interests in hobbies, religion, politics and alternative lifestyles. A social networking service is a platform to build social networks.
CRWE is looking to deliver value for its stockholders in both the near and long term, targeting the multi-billion dollar social networking service market.
CRWE is currently developing a social networking service and phone app, CRWE Network ( CRWE-PR.com ), that is designed to target all the communities in every state of the United States, with its geographic focus starting in Southern California and Las Vegas Nevada.
CRWE Network Travel Search is an information source for travelers searching for hotels, airline tickets, car rentals, cruise deals, Las Vegas events tickets, to find the cheapest vacations online
CRWE ‘s business plan is based on selling advertising to local businesses. Its goal is to facilitate exchanges of goods and services in a manner similar to Craigslist, a classified advertisements website with sections devoted to jobs, housing, personals, for sale, items wanted, services, community, gigs, résumés, and discussion forums.
CRWE offers advertising branding and marketing services as a worldwide online multi-media publisher.
More about Crown Equity Holdings Inc. (CRWE) at www.crownequityholdings.com .
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ZOOM Technologies, Inc. (ZOOM)
ZOOM reported that it has entered into a Letter of Intent (LOI) with Tinho Union Holding Group, a B2B e-commerce platform provider for the travel industry in China, to acquire all the outstanding shares of Tinho by issuing approximately 9.4 million new shares of ZOOM 's common stock at a valuation of $8.6505 per share to the shareholders of Tinho.
The transaction is subject to shareholder approval by both parties and other closing conditions.
ZOOM is a holding company that expects to invest in mobile and telecommunications businesses.
More about ZOOM Technologies, Inc. (ZOOM) at www.zoom.com
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