Yep. We have evolved with cannabis. Cannabinoid receptor Most dense receptor in the brain. We have been cannabinoid deficient as a peoples because of fear. The whole increasing THC potency has had a negative effect as well. Kinda like the difference between chewing in coca leaf and cocaine. We are designed to have our cannabinoid receptors getting dosed. Dharmanol is the new era....it is juiced leaves in a supplement.