Pillar Biosciences Innovates NGS Library Preparation for MPN
Pillar Biosciences, Inc., and Hamilton Company recently made an exciting announcement about the validation and release of a groundbreaking automated method for next-generation sequencing (NGS) library preparation designed to bolster research in myeloproliferative neoplasms (MPN). This innovative automation technology is specifically tailored for use with the renowned Hamilton Microlab STAR liquid handling systems.
Advancements in NGS Technology
The new automation method involves the oncoReveal Essential MPN panel, a powerful tool that evaluates MPNs by tracking mutations in three critical genes: JAK2, CALR, and MPL. This first-of-its-kind NGS panel has been optimized for automation on the Hamilton Microlab STAR, allowing for efficient handling of samples.
Key Features of the New Automation Method
The oncoReveal Essential MPN method facilitates the preparation of up to 96 NGS libraries in a single run. Here are some standout features:
- Efficient Sample Processing: The integration of synchronous on-deck operations along with the Multi-Probe Head (MPH) makes the sample processing remarkably swift.
- Flexible Throughput: Users can select from 8 to 96 libraries per run, adaptable in increments of 8.
- User-Friendly Interface: An intuitive interface guides users through every step of the process with ease.
- Streamlined Workflow: The method requires minimal hands-on effort for preparing samples and reagents, as it eliminates mandatory mid-run tip reloads.
- Economical Reagent Usage: Optimized pipetting techniques minimize dead volume and waste, contributing to cost efficiency.
Expert Insights on the New System
Joseph Goffreda, an Automation Specialist at Pillar Biosciences, commented on the growing global demand for automated NGS panels. He remarked, "The oncoReveal NGS Kits using our innovative SLIMamp enrichment chemistry are designed to integrate seamlessly with the Hamilton STAR systems, simplifying NGS workflows while providing rapid and precise results. This advancement reflects our commitment to enhancing cancer research."
Additionally, Michael Mouradian, Vice President of Scientific Strategy and Market Development at Hamilton, expressed enthusiasm over this collaboration. He stated, "We are excited to achieve this initial milestone with Pillar Biosciences. Merging Pillar’s simplified NGS library preparation method with our advanced liquid handling systems opens doors for faster and more efficient research in MPN and beyond. This alignment brings forth a game-changing solution for researchers worldwide."
About Pillar Biosciences
Pillar Biosciences is a pioneer in Decision Medicine™, harnessing sophisticated NGS technology to enable informed therapy choices for cancer patients. Their methods emphasize swift tumor profiling, therapy selection, and disease recurrence monitoring. Through its proprietary technologies, SLIMamp and PiVAT, Pillar aims to localize testing, enhance accessibility, reduce diagnostic expenses, and streamline the complex testing processes in clinical settings globally. The company boasts an extensive portfolio of over 20 testing kits available for varied clinical applications, with several panels currently under development.
About Hamilton
Hamilton is recognized for its leadership in automated liquid handling technology. As a manufacturer of innovative laboratory systems, Hamilton integrates patented technologies with a diverse range of products, including liquid handling platforms and customized solutions. The company is committed to improving performance, reliability, and operational flexibility within multiple scientific markets including life sciences, clinical diagnostics, and biotechnology. Hamilton adheres to stringent quality standards and is certified ISO 9001, ensuring excellence in every aspect of its operations.
Frequently Asked Questions
What is the significance of the new NGS library preparation method?
This method enhances the efficiency and accuracy of preparing NGS libraries, crucial for myeloproliferative neoplasm research.
How many samples can be processed at once?
The system can process up to 96 libraries in a single continuous run, offering flexibility in sample throughput.
What are the key benefits of using this automated system?
Benefits include reduced processing time, user-friendly interface, minimal hands-on time, and economical reagent usage.
Who are the key players involved in this collaboration?
Pillar Biosciences and Hamilton Company are the primary collaborators in developing this innovative NGS library preparation method.
Where can I find more information about Pillar Biosciences?
Further information is available on their official website, where insights about their products and technologies are provided.
