PeptiDream Unveils New Therapeutic Program for Gastric Cancer

PeptiDream Launches Innovative Peptide Radiopharmaceutical Program

PeptiDream Inc., a prominent biopharmaceutical company located in Kanagawa, Japan, has recently disclosed an exciting new chapter in its development journey. This initiative centers around a promising peptide radiopharmaceutical therapeutic program aimed at targeting Claudin 18.2 (CLDN18.2), a protein of great significance in the context of gastric cancer. The new therapeutic candidate is identified as PD-29875, representing the company’s second internally developed project in this innovative area. This announcement signals PeptiDream's ongoing commitment to addressing critical medical needs in oncology.

Understanding Claudin 18.2 and Its Impact on Cancer

CLDN18.2 is a member of the claudin family, essential proteins found in tight junctions of epithelial tissues. This particular protein's expression is notably prominent in various solid tumors, such as pancreatic cancer, biliary cancer, and colorectal cancer, in addition to gastric cancer. The connection between CLDN18.2 and these types of cancers highlights its potential as a robust target for therapeutic interventions.

The Role of PD-29875

PD-29875, the latest development from PeptiDream, is a first-in-class macrocyclic peptide-radioisotope conjugate designed with high selectivity for CLDN18.2. Through its proprietary Peptide Discovery Platform System (PDPS), PeptiDream has identified and optimized this candidate, which has undergone comprehensive in vivo imaging and efficacy studies through its subsidiary, PDRadiopharma. The dual focus on developing both a therapeutic option and a paired diagnostic imaging agent positions PD-29875 uniquely in the market.

Clinical Development Pathway

PeptiDream has embarked on IND-enabling studies for PD-29875, which include the treatment (using the therapeutic agent 225Ac-PD-29875) and paired diagnostic imaging agent (64Cu-PD-29875). This diagnostic tool is intended to effectively screen patients expressing CLDN18.2 in their tumors, helping to ensure those most likely to benefit from treatment are identified. The strategy not only enhances the therapeutic use of PD-29875 but also integrates into routine clinical practices, ensuring broader accessibility for patients in need.

The Urgency of Gastric Cancer Treatments

Gastric cancer remains a substantial global health challenge, being the fifth most prevalent cancer worldwide and the fourth leading cause of cancer-related deaths. With a troubling five-year survival rate of just 32%, the urgency for effective treatments has never been more apparent. The projections indicate that by 2040, the incidence of gastric cancer could skyrocket to approximately 1.8 million new cases annually. This context underscores the importance of PeptiDream’s efforts in advancing PD-29875 through clinical studies, with human imaging studies planned for 2025.

Expert Insights on PeptiDream's Vision

Patrick C. Reid, PhD, President and CEO of PeptiDream, expressed enthusiasm about the company's latest developments, underscoring the high unmet medical needs within gastric cancer treatment options. He stated, “We are preparing to potentially take PD-29875 into human imaging studies in 2025, before bringing the therapeutic and paired diagnostic into clinical development. Our PDPS platform continues to prove extremely effective in discovering novel macrocyclic peptides for the targeted delivery of conjugated radionuclide payloads to tumors.” Reid's comments highlight not only PeptiDream’s advancements but also a broader vision to expand their cancer treatment pipeline further.

About PeptiDream Inc.

Founded as a leading entity in the biopharmaceutical landscape, PeptiDream Inc. is redefining the future of treatment with its groundbreaking approach to macrocyclic peptides. The company is dedicated to translating innovative peptide discoveries into advanced therapeutic solutions that satisfy unmet medical needs. PeptiDream, through PDRadiopharma, actively markets a range of approved radiopharmaceuticals in Japan, while continuously enriching its portfolio with new, targeted raditherapeutics and diagnostics. This commitment to improving the quality of life for patients around the world demonstrates PeptiDream's impactful role in the evolving field of oncology.

Frequently Asked Questions

What is the significance of PD-29875?

PD-29875 is a novel peptide radiopharmaceutical candidate targeting CLDN18.2 for the diagnosis and treatment of gastric cancer, addressing a critical area in oncology.

How does PeptiDream plan to assess PD-29875's effectiveness?

PeptiDream will conduct IND-enabling studies and human imaging studies, aiming to evaluate the clinical responses of patients receiving the treatment.

What impact does gastric cancer have globally?

Gastric cancer is a major health concern, with rising cases and low survival rates; it is the fifth most common cancer worldwide.

What technologies does PeptiDream utilize?

PeptiDream employs its proprietary PDPS technology, which aids in the discovery and development of targeted peptide therapeutics.

What future plans does PeptiDream have?

PeptiDream aims to continue expanding its pipeline of peptide-RI conjugate therapies for various cancers, enhancing patient outcomes through innovative treatments.

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