New Clinical Findings on Cadonilimab Advance Cancer Treatment

Insights into Cadonilimab for Advanced Gastric Cancer

Akeso, Inc. (9926.HK) is pleased to share significant updates following the publication of its groundbreaking research in the esteemed journal, Nature Medicine. The study focuses on cadonilimab, a dual-target PD-1/CTLA-4 bispecific antibody designed for the first-line treatment of advanced gastric cancer. The results showcase cadonilimab's potential when combined with standard chemotherapeutics, oxaliplatin, and capecitabine, in addressing advanced gastric or gastroesophageal junction adenocarcinoma.

Cadonilimab's Validation through Research

This publication not only highlights the efficacious nature of cadonilimab but also reinforces its role in meeting critical patient needs. Prior to this, cadonilimab's effectiveness in various cancers has garnered attention in several prestigious journals, including The Lancet and Clinical Cancer Research. The recognition from Nature Medicine signifies a considerable step forward in cancer treatment research.

Impressive Clinical Outcomes

The recent clinical study released in Nature Medicine revealed compelling evidence that cadonilimab, regardless of PD-L1 expression, significantly enhances overall survival for patients battling advanced gastric cancer. With an overall survival hazard ratio of 0.62, the results underscore the survival benefit even for patients showing low or negative PD-L1 expression (OS HR 0.70). This breakthrough effectively addresses long-standing challenges within PD-1 monoclonal antibody treatments.

Expanding Treatment Options

Following its approval for first-line treatment in September 2024, cadonilimab is set to transform clinical practices. The ongoing development includes a Phase III trial assessing cadonilimab alongside a VEGFR-2 monoclonal antibody, aiming to enhance outcomes for previously treated advanced gastric cancers. Akeso's strategic approach is focused on broadening cadonilimab's indications, ensuring that more patients can benefit from effective immunotherapy.

Targeting Multiple Cancer Types

Cadonilimab is currently under investigation in over 23 clinical trials targeting various malignancies including gastric, lung, liver, cervical, and pancreatic cancers. The drug showcases remarkable efficacy across a diverse patient population, encompassing those with varying PD-L1 expression levels. Notably, cadonilimab already holds approval for recurrent or metastatic cervical cancer, with first-line gastric cancer treatment widely adopted.

Potential for the Future

Remarkably, cadonilimab is also advancing in several Phase III trials for liver cancer and non-small cell lung cancer. The drug has exhibited breakthrough efficacy among diverse patient populations, highlighting its potential as a cornerstone in next-generation cancer immunotherapy. Its capability to synergistically target both PD-1 and CTLA-4 establishes cadonilimab as a frontrunner in the global bispecific antibody landscape.

Frequently Asked Questions

What is cadonilimab?

Cadonilimab is a bispecific antibody targeting both PD-1 and CTLA-4 pathways, aimed at enhancing immune response against tumors.

How does cadonilimab work in cancer treatment?

Cadonilimab works by inhibiting immune checkpoints that cancer cells exploit to evade the immune system, thus improving overall survival rates in patients.

What are the results published in Nature Medicine?

The results illustrate that cadonilimab significantly improves overall survival for advanced gastric cancer patients, irrespective of their PD-L1 expression status.

Is cadonilimab approved for clinical use?

Yes, cadonilimab was approved for first-line treatment of advanced gastric cancer and is now being widely implemented in clinical settings.

What future studies are planned for cadonilimab?

Ongoing studies include trials evaluating cadonilimab's effectiveness when combined with other therapies, further expanding its indications across cancer types.

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