Tubulis Marks a Significant Breakthrough in ADC Development
Tubulis Achieves a Milestone in Cancer Treatment Development
Tubulis has made significant strides in the field of cancer treatment with the recent announcement that its first program from a strategic collaboration has entered clinical development. This marks a key milestone in Tubulis' efforts to innovate with next-generation antibody drug conjugates (ADCs). The partnership established with Bristol Myers Squibb combines their extensive oncology expertise with Tubulis' advanced Tubutecan technology to develop unique therapeutic options for solid tumors.
Understanding Tubutecan Technology
Tubulis' proprietary Tubutecan technology represents a breakthrough in ADC design. This method integrates a P5 conjugation system with an exatecan payload, resulting in stable and highly targeted ADCs. This enables the effective delivery of topoisomerase-1 inhibitors directly to tumor sites while reducing overall toxicity to healthy tissues. This innovation has the potential to overcome significant barriers associated with earlier ADC generations, thus providing new treatment avenues for patients suffering from aggressive and difficult-to-treat solid tumors.
Clinical Development and Future Prospects
As of now, Tubulis has successfully moved three Tubutecan-based ADC candidates into clinical trials within a remarkably short period. This includes their lead programs, TUB-030 and TUB-040, which are aimed at addressing high-need solid tumor indications. CEO Dominik Schumacher emphasizes the company's commitment to expanding its ADC pipeline and leveraging their robust partnership with Bristol Myers Squibb to deliver more effective cancer treatments.
Partnership with Bristol Myers Squibb
The collaboration with Bristol Myers Squibb was formalized to accelerate the development of several differentiated ADCs. Under this agreement, Tubulis will receive milestone payments tied to development and regulatory achievements, as well as royalties on commercialized products. This combination of resources and expertise not only boosts Tubulis’ innovation potential but also enhances the overall prospects for successful cancer therapies.
About Tubulis
Tubulis is dedicated to producing uniquely matched ADCs that exhibit superior biophysical properties. Their advanced drug candidates have been demonstrated to achieve durable delivery to tumor sites, resulting in long-lasting anti-tumor activity in preclinical models. Their focus remains on enhancing the therapeutic applications of ADCs, with plans to solidify their leadership role in the biotechnology landscape through relentless innovation.
Contact Information
For those seeking more information about Tubulis and their innovative therapies, the direct contact is:
Dominik Schumacher, CEO & Co-founder
Phone: +49 (0) 175 800 5594
Email: contact@tubulis.com
Frequently Asked Questions
What is Tubulis' recent achievement?
Tubulis announced that its first program from a strategic collaboration entered clinical development, marking a significant milestone.
What technology does Tubulis use?
Tubulis employs a proprietary Tubutecan technology that enables the development of stable, highly targeted antibody-drug conjugates (ADCs).
Who are Tubulis' partners in their ADC development?
The company collaborates with Bristol Myers Squibb, leveraging their clinical expertise to enhance cancer treatment options.
What are the lead programs of Tubulis?
The lead programs TUB-030 and TUB-040 are currently being evaluated for their effectiveness against high-need solid tumors.
How does Tubulis plan to expand its pipeline?
By continuing to innovate ADC design and leveraging their proprietary platform, Tubulis aims to enhance therapeutic potential in oncology.
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