TriLink BioTechnologies Partners with Aldevron for mRNA Innovation
TriLink BioTechnologies and Aldevron Forge a New Partnership
TriLink BioTechnologies, part of Maravai LifeSciences, is paving the way for innovative advances in mRNA technology through a recent partnership with Aldevron, a prestigious Contract Development and Manufacturing Organization (CDMO). This collaboration is set to enhance the access to CleanCap® mRNA capping technologies, which are crucial for those in the race to develop effective mRNA-based therapeutics and vaccines.
Impact of the Licensing Agreement
The new non-exclusive License and Supply Agreement allows TriLink to provide its exceptional CleanCap® technology to Aldevron. This cutting-edge technology includes their patented CleanCap® M6, CleanCap® AG 3'OMe, CleanCap® AG, and CleanCap® AU cap analogs that will be utilized in Aldevron’s mRNA development services, spanning pre-clinical trials to Phase III programs for various therapeutic solutions.
What makes CleanCap® technology so remarkable is its efficiency—boasting over 95% efficiency in producing optimal 5’ Cap structures. This revolutionary co-transcriptional capping method dramatically enhances mRNA yield and process time compared to traditional methods that have been used in earlier developments.
Transforming Drug Development Milestones
Becky Buzzeo, the Chief Commercial Officer of Maravai, expressed enthusiasm about this partnership, noting how CleanCap technology has accelerated numerous drug development programs. She emphasized that it has been the preferred choice for mRNA constructs in more than 350 clinical and preclinical trials.
Since its introduction in 2017, the CleanCap® technology has significantly transformed the mRNA capping landscape, being integral to the majority of approved COVID-19 mRNA and saRNA vaccines. In mid-2023, TriLink unveiled its most advanced CleanCap® analog, CleanCap® M6, promising enhanced mRNA expression surpassing enzymatic capping methods by over 30%.
Aldevron's Commitment to Development
Aldevron’s reputation as a leader in biological science is cemented by its commitment to providing high-quality plasmid DNA, RNA, and proteins. Their role as a manufacturing partner is essential for researchers who are striving to pioneer groundbreaking treatments and therapies.
This strategic partnership means that researchers and developers will have improved access to cutting-edge mRNA technologies, offering a robust platform to accelerate their research and product development initiatives.
About TriLink BioTechnologies
TriLink BioTechnologies stands out as a global frontrunner in nucleic acid and mRNA solutions. With a rich background in chemical and biological services, they provide high-quality ready-made and customized materials, prominently featuring their patented CleanCap® mRNA capping technology. Renowned pharmaceutical companies, biotech innovators, and various governmental bodies rely on TriLink to deliver on challenges such as developing COVID-19 vaccines and pioneering forward-thinking treatments for diseases across oncology, infections, cardiovascular issues, and neurological disorders.
About Maravai LifeSciences
Maravai is a notable entity in the life sciences sector, delivering essential products that facilitate the advancement of drug therapies, diagnostics, and novel vaccines. Recognized for its comprehensive contributions in nucleic acid synthesis and biologics safety testing, Maravai serves many of the world’s leading biopharmaceutical and biotechnological firms.
About Aldevron
Aldevron is celebrated as a premier partner in manufacturing essential biological components such as plasmid DNA, RNA, and proteins. As part of the Danaher Corporation family, Aldevron is instrumental in supporting scientists dedicated to developing innovative, life-saving therapies.
Frequently Asked Questions
What is the CleanCap® technology?
CleanCap® technology is an advanced mRNA capping method that enhances yield and efficiency in mRNA synthesis, significantly improving the drug development process.
What companies are involved in the new agreement?
TriLink BioTechnologies has entered into a partnership with Aldevron to enhance mRNA development capabilities.
How has CleanCap® technology impacted vaccine development?
CleanCap® technology has been crucial in developing the majority of approved COVID-19 vaccines, improving the speed and efficacy of mRNA therapies.
What does this partnership mean for researchers?
This partnership means researchers will have greater access to cutting-edge mRNA technologies, accelerating their development of critical therapeutic solutions.
What are TriLink's main areas of expertise?
TriLink specializes in nucleic acid solutions and mRNA technology, providing high-quality reagents and services for pharmaceutical and biotechnological applications.
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