Transgene Advances Phase II Trial with Promising Results for Cancer Vaccine
Transgene’s Groundbreaking Progress in Cancer Immunotherapy
Transgene, known for its innovative approach in developing virus-based immunotherapies, recently made a significant step forward with the completion of initial patient screening in the Phase II of the TG4050 clinical trial. This trial focuses on operable HPV-negative squamous head and neck cancers, where TG4050 is assessed as a standalone therapeutic vaccine.
Impressive Outcomes from the Phase I Study
Highlights of Phase I Results
The Phase I segment of the trial revealed remarkable outcomes, with a 100% rate of disease-free survival after a minimum two-year follow-up. These results have provided robust clinical proof of TG4050's potential efficacy. The next stages of the trial are set to build on this foundational success.
Future Expectations
Transgene anticipates completing the randomization process for all patients involved in this Phase II segment by the end of 2025. With additional screenings taking place after surgical procedures and adjuvant therapies, the company aims to enroll about 80 patients demonstrating a complete response to initial treatment. Furthermore, the first set of immunogenicity data is expected to be available in the second half of 2026, with preliminary efficacy results anticipated in 2027.
Insights from Transgene’s Leadership
Chief Medical Officer's Perspective
Dr. Emmanuelle Dochy, MD, and Chief Medical Officer of Transgene, emphasized that the timely completion of patient screening is vital for the company and the potential options it provides for patients battling operable head and neck cancer. She expressed gratitude towards the patients and all contributors involved in the study, underscoring the collaborative effort necessary for such achievements.
CEO’s Vision for the Future
Dr. Alessandro Riva, Transgene’s CEO, praised the positive results from the Phase I trial, highlighting how it supports the potential of the myvac® platform utilized in TG4050. He conveyed the agility and efficiency the team has shown in advancing the trial and upcoming preparations for a new Phase I trial in an undisclosed indication, aiming for initiation in late 2025.
About Transgene and Its Innovative Approaches
Company Overview
Transgene (Euronext: TNG) specializes in the design and development of innovative immunotherapies targeting cancer. Their lead product, TG4050, is a unique therapeutic vaccine derived from the myvac® platform, which integrates patient-specific mutations driving tailored treatment solutions. This approach allows for precise targeting of tumors based on individual genetic profiles.
Expanding Horizons with myvac®
The myvac® platform has garnered attention for its capability to stimulate the immune system to recognize and combat tumors utilizing personal genetic data. The ongoing evolution of this technology, combined with the sophisticated AI systems developed in partnership with NEC, is set to enhance Transgene’s offerings in the oncological treatment landscape.
Frequently Asked Questions
What is TG4050?
TG4050 is an individualized therapeutic vaccine developed by Transgene for treating HPV-negative head and neck cancers, utilizing the company’s myvac® platform.
What were the results from the Phase I trial?
The Phase I trial reported a 100% disease-free survival rate after at least two years, showcasing strong potential for TG4050 in cancer treatment.
When is the expected completion of patient randomization?
Transgene aims to finalize the randomization of patients in the Phase II trial by the end of 2025.
What data is anticipated in the coming years?
Immunogenicity data from Phase II is expected in the second half of 2026, followed by preliminary efficacy data in 2027.
Who can I contact for more information about Transgene?
For media inquiries, contact Caroline Tosch. For investor relations, reach out to Lucie Larguier or Nadege Bartoli. Contact details can be found on Transgene's official website.
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