SpringWorks Therapeutics Shares Insight on Q4 2024 Performance

SpringWorks Therapeutics Reflects on Fourth Quarter and 2024 Achievements

SpringWorks Therapeutics, Inc. (Nasdaq: SWTX), a biopharmaceutical company dedicated to treating severe rare diseases and cancer, has reported strong preliminary fourth quarter and full year financial results for 2024. The company achieved notable U.S. net product revenues of $61.5 million in the fourth quarter and a total of $172.0 million for the year from its innovative therapy, OGSIVEO (nirogacestat).

As of the end of 2024, SpringWorks maintained a robust financial position with approximately $462 million in cash, cash equivalents, and marketable securities. This solid cash position indicates that the company is well-poised for further growth and intends to reach profitability by the first half of 2026.

Key Financial Highlights and Business Updates

The company presented its financial results and business updates during the prestigious 43rd Annual J.P. Morgan Healthcare Conference, emphasizing the importance of ongoing investment in its investigational pipeline and commercial execution strategies.

Financial Performance Overview

• The recorded preliminary U.S. net product revenue of $61.5 million for Q4 and $172.0 million for the entire year demonstrates strong market demand and commercial execution for OGSIVEO.
• SpringWorks forecasts that its existing cash reserves will be adequate to support its ongoing operations until it achieves profitability.

Clinical Developments

• The company showcased long-term follow-up data from its Phase 3 DeFi trial, which evaluated the effectiveness of nirogacestat in adults with progressing desmoid tumors. Results indicated significant tumor size reduction and improved patient outcomes.
• Additionally, a global license agreement was secured from Rappta Therapeutics Oy for a novel therapeutic targeting Protein Phosphatase 2A (PP2A), which is crucial in treating specific uterine cancers.

2025 Goals and Upcoming Milestones

Looking ahead, SpringWorks has set ambitious priorities for 2025, aimed at broadening its impact within the medical community and ensuring patient access to essential therapies.

Strategic Initiatives for OGSIVEO

• The company aims to drive the commercial launch of OGSIVEO in the U.S. while actively pursuing regulatory approval in the European Union.
• SpringWorks plans to publish pivotal data from the Phase 3 DeFi trial in peer-reviewed journals and report initial trial data on nirogacestat for ovarian granulosa cell tumors.
• Collaborative studies will be supported to explore nirogacestat in combination therapies for multiple myeloma, suggesting a proactive commitment to innovative treatment strategies.

Advancing Mirdametinib (NF1-PN)

• SpringWorks expects to secure FDA approval for mirdametinib, aimed at treating NF1-associated plexiform neurofibromas, by the end of February 2025.
• Parallel efforts in the EU are underway to introduce mirdametinib for both adult and pediatric patients.

Emerging Pipeline Developments

• In the second half of 2025, additional trial data from MapKure's brimarafenib will be revealed, reflecting SpringWorks’ commitment to an evolving pipeline of promising therapies.
• The company is set to file an Investigational New Drug (IND) application for its innovative therapy SW-3431 by year-end, further diversifying its treatment offerings.

According to Saqib Islam, Chief Executive Officer of SpringWorks, "2025 is poised to be transformative for the company, with the anticipated launches of new therapies and our global outreach efforts to combat rare diseases effectively. We remain committed to supporting underserved patient populations," he stated enthusiastically.

Engagement at the 43rd Annual J.P. Morgan Healthcare Conference

During the conference, SpringWorks shared insights into its strategies for commercializing its leading therapies and expanding the reach of its innovative treatments, reinforcing its dedication to patient communities and healthcare advancements.

About SpringWorks Therapeutics

SpringWorks is a commercial-stage biopharmaceutical company focusing on precision medicine to develop impactful therapies for severe rare diseases and cancer. Its flagship therapy, OGSIVEO, has been FDA-approved for adult patients with progressing desmoid tumors, marking a significant milestone in its therapeutic portfolio.

The company is also developing a comprehensive pipeline that spans solid tumors and hematological malignancies, addressing critical needs in oncology. SpringWorks remains committed to collaborations and innovation to enhance patient care.

Frequently Asked Questions

What are the preliminary financial results for SpringWorks in Q4 2024?

SpringWorks reported U.S. net product revenues of $61.5 million for Q4 and $172.0 million for the full year 2024.

What is OGSIVEO, and what are its indications?

OGSIVEO (nirogacestat) is a therapy approved for treating adult patients with progressing desmoid tumors requiring systemic treatment.

What strategic plans does SpringWorks have for 2025?

The company aims to launch OGSIVEO in the EU, enhance clinical trial data publication, and secure FDA approvals for mirdametinib.

How does SpringWorks support innovation in rare diseases?

SpringWorks focuses on precision medicine and collaborates on clinical trials to target severe rare diseases that lack effective treatments.

How can investors get more information about SpringWorks Therapeutics?

Investors can access detailed information on SpringWorks through their corporate website and by monitoring their press releases and SEC filings.

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