ProBio Showcases Cutting-Edge Innovations at ASGCT 2025
ProBio Showcases Cutting-Edge Innovations at ASGCT 2025
ProBio recently announced its participation in the American Society of Gene and Cell Therapy (ASGCT) 28th Annual Meeting, where it will feature six informative poster presentations that delve into the latest advancements in the realm of DNA and viral vector manufacturing. These presentations underscore ProBio's commitment to advancing cell and gene therapy, with a focus on innovations that push the boundaries of what's possible.
Innovations in Gene Therapy Manufacturing
As a premier contract development and manufacturing organization (CDMO), ProBio is positioning itself at the forefront of the biotechnology landscape. The innovations that will be highlighted during ASGCT include methodologies for plasmid DNA production, enzymatic processes for linearized DNA pertaining to mRNA therapeutics, and systematic optimizations surrounding the manufacturing of recombinant AAV and lentiviral vectors. These advancements aim to enhance efficiency and reliability in developing new therapies.
Commitment to Quality and Efficiency
“Our presence at ASGCT this year illustrates ProBio's unwavering dedication to pushing the frontiers of gene and cell therapy through our cutting-edge manufacturing solutions,” said Allen Guo, CEO of ProBio. The ability to provide scalable production and maintain high-quality standards is essential for meeting the demands characteristic of pre-clinical and clinical development. ProBio's state-of-the-art facilities are engineered to drive progress in the development not only of therapies but of the methodologies that underpin their success.
Highlighting Poster Presentations
The presentations at ASGCT are expected to gather significant attention and shed light on the following areas:
- Advanced Plasmid Linearization: This method utilizes Type I and II restriction enzymes to create a high-purity, scalable platform tailored for cell and gene therapy applications.
- Enhanced Plasmid Biomanufacturing: ProBio's PowerS-ITR E. coli platform has yielded remarkable improvements in yield and structural integrity.
- Optimization Studies: Insights into comparative analyses of host cell DNA/RNA quantification approaches, involving both cost-effective agarose gel electrophoresis and high-sensitivity qPCR techniques.
- Viral Vector Production: An efficient cell line designed specifically for viral vector generation, namely PowerS™-293/293T, promises to optimize the production landscape.
- Quality by Design: Implementing a digital Quality Management System (QMS) that ensures excellence in risk-based manufacturing tailored for plasmid DNA and gene therapy needs.
- Enzymatic Linearized DNA: An innovative approach that provides a cell-free platform for expediting mRNA therapeutic development.
Opportunities for Collaboration
ProBio is eager to engage with innovators, collaborators, and potential partners during ASGCT 2025, encouraging discussions on how its flexible strategies can support partners in their cell and gene therapy endeavors. The goal is to shape future therapies that will cement significant advancements in treating various diseases.
About ProBio
ProBio is recognized globally for spearheading the growth of next-generation biologics and advanced therapies tailored for the evolving biotech and pharmaceutical sectors. Acting as a fully integrated CDMO, it partners with clients to streamline drug development, curtail time-to-market, and provide extensive life-cycle support. Through a collaborative approach, ProBio embraces flexible licensing and co-development avenues to navigate the complexities associated with human diseases effectively.
ProBio’s commitment to innovation and quality remains evident in its operations as it strives to meet the challenges of the biotechnology industry head-on.
Frequently Asked Questions
What are the key innovations presented by ProBio at ASGCT 2025?
ProBio is presenting innovations in plasmid DNA production, viral vector manufacturing, and enzymatic processes for mRNA therapeutics.
Who is Allen Guo?
Allen Guo is the CEO of ProBio, who emphasized the organization’s commitment to advancing cell and gene therapy.
How does ProBio support gene therapy development?
ProBio supports gene therapy development by providing scalable, high-quality manufacturing solutions that address clinical and pre-clinical needs.
Where is ProBio located?
ProBio operates state-of-the-art facilities designed for advanced biotechnology applications.
How can interested parties connect with ProBio at ASGCT 2025?
ProBio invites innovators and collaborators to visit their exhibits at the meeting to discuss partnership opportunities and learn more about their solutions.
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