Posted On: 09/13/2013 3:03:53 AM
Post# of 72446
Oh! I am so sorry about your yellow lab friend! Awful.
So Pete - I haven't had time to review that pipeline yet. But Kard hires MS and PhD level scientists - so Menon won't have to babysit. He'll give overarching instructions - have the isomer specialist start looking for isomers, reverse isomers, etc... Have the structural 'bond' or 'allele' person break the bonds holding the active molecule together and try new structure with different bonds that might create less toxicity. Maybe he'll try isomer wrapped in fatty coating to see how it metabolizes over glycerin coating, etc...Polkadot would really be able to explain what the lab activity might look like - I'm just guessing - but either way, Menon has competent people there who'll report to him when they make progress.
Don't have to go back to square one usually with reformulated drug... But.... none of these drugs were approved so if they reformulate they don't have many shortcuts available they way they would if they reformulated a drug already in use.
So Pete - I haven't had time to review that pipeline yet. But Kard hires MS and PhD level scientists - so Menon won't have to babysit. He'll give overarching instructions - have the isomer specialist start looking for isomers, reverse isomers, etc... Have the structural 'bond' or 'allele' person break the bonds holding the active molecule together and try new structure with different bonds that might create less toxicity. Maybe he'll try isomer wrapped in fatty coating to see how it metabolizes over glycerin coating, etc...Polkadot would really be able to explain what the lab activity might look like - I'm just guessing - but either way, Menon has competent people there who'll report to him when they make progress.
Don't have to go back to square one usually with reformulated drug... But.... none of these drugs were approved so if they reformulate they don't have many shortcuts available they way they would if they reformulated a drug already in use.
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