" Overall purpose is to find a method to manipulate IDO for clinical applications, mainly the focus of this review is is cancer prevention and treatment. The first study proving the connection between IDO and immune response came from, a very natural event, a protection of pregnancy in human. This led to discover that high IDO expression is a common factor in cancer tumors. Thus, attention promoted investigations on IDO’s role in various disease states, immune disorders, transplantation, inflammation, women health, mood disorders. Many approaches, vaccines and adjuvants are underway to find new immunotherapies by combining the power of DCs in immune response regulation and specific direction of siRNA . As a result, with this unique qualities of IDO, DCs and siRNA, we orchestrated a novel intervention for immunomodulation of IDO by inhibiting with small interference RNA, called siRNA-IDO-DCvax. Proven that our DCvax created a delay and regression of tumor growth without changing the natural structure and characterization of DCs in melanoma and breast cancers in vivo. (** The shRNA IDO- DCvax is developed by Regen BioPhrama, San Diego, CA , Thomas Ichim, Ph.D, CSO. and David Koos, CEO)"
Current IDO Clinical Trials; short version. Is a matter of time before Regen will be among these listed.
| 1 | Clinical Trials From Clinicaltrials.Gov Title And Details Of The Study | NCT Number | Recruitment | Condition | Primary Completion Date | Sponsor/Collaborator | Phase or Observation.
| Intervention Type |
| 2 | IDO Inhibitor Study For Relapsed Or Refractory Solid Tumors
| NCT00739609 | Terminated | Breast Cancer|Lung Cancer|Melanoma|Pancreatic Cancer|Solid Tumors
| October 2012 | NewlLink enetics Corp. | 1 | CHEM |
| 3 | IDO2 Genetic Status Informs The Neoadjuvant Efficacy Of Chloroquine (CQ) In Brain Metastasis Radiotherapy
| NCT01727531 | Recruiting | Brain Metastasis | Dec. 2020 | Main Line Health | NA | CHEM |
| 4 | Peptide Vaccine And Temozolomide For Metastatic Melanoma Patients
| NCT01543464 | Recruiting | Malignant Melanoma | September 2014
| Newlink Genetics Corporation | 2 | CHEM |
| 5 | A Phase 1/2 Randomized, Blinded, Placebo Controlled Study Of Ipilimumab In Combination With INCB024360 Or Placebo In Subjects With Unresectable Or Metastatic Melanoma
| NCT01604889 | Recruiting | Metastatic Melanoma | August 2014 | Incyte Corporation | 1/2 | BIOL INH+ CHEM |
| 6 | A Phase 2 Study Of The IDO Inhibitor INCB024360 Versus Tamoxifen For Subjects With Biochemical-Recurrent-Only EOC, PPC Or FTC Following Complete Remission With First-Line Chemotherapy
| NCT01685255 | Recruiting |
| April 2014 | Incyte Corporation | 2 | CHEM |
| 7 | Different Injection Number Of The Same Dose Of Botulinum Toxin A On Overactive Bladder Syndrome
| NCT01657409 | Recruiting | Overactive Bladder
| March 2014
| Buddhist Tzu Chi General Hospital | 2 | CHEM |
| 8 | Study On The Effect Of Intravenous Ascorbic Acid On Intraoperative Blood Loss In Women With Uterine Myoma Interventions: Drug: Ascorbic Acid | NCT01715597 | Recruiting | Uterine Leiomyoma
| January 2014
| Seoul National University Hospital | 3 | CHEM |
|
9 | 1-Methyl-D-Tryptophan In Treating Patients With Metastatic Or Refractory Solid Tumors That Cannot Be Removed By Surgery | NCT00567931 | Recruiting | Unspecified Adult Solid Tumor, Protocol Specific | September 2013 | National Cancer Institute (NCI) | 1 | CHEM |
| 10 | Properties Of Mesenchymal Stem Cells In Lung Transplant
| NCT01668576 | Recruiting | Lung Transplantation
| August 2013
| Emory University | OBS | BIOL |
| 11 | The Effects Of Medical Clowns In Children Undergoing Blood Tests
| NCT01396876 | Recruiting | Pain And Anxiety Reduction
| July 2012
| Tel-Aviv Sourasky Medical Center | NA | BIOL |
| 12 | Saline Injection - Assisted Anesthesia In Eyelid Surgery
| NCT01239498 | Recruiting | Blepharoptosis | October 2011
| Sheba Medical Center | 4 | CHEM BIOL |
| 13 | Effects Of The Consumption Of California Walnuts On Cardiovascular Health Interventions: Dietary Supplement: Walnuts
| NCT01235390 | Recruiting | Cardiovascular Disease|Immune Health | October 2011 | University Of California, Davis|California Walnut Commission | 1 | FOOD ALERGY-WALNUT |
| 14 | Pomegranate To Reduce Maternal And Fetal Oxidative Stress And Improve Outcome In Pregnancies Complicated With Preterm Premature Rupture Of The Membranes
| NCT01584323 | Recruiting | Preterm Premature Rupture Of Membranes|Pregnant State
| 2013 | Rambam Health Care Campus | NA | FOOD SUP |
| 1 | Phase II INCB024360 Study For Patients With Myelodysplastic Syndromes (MDS)
| NCT01822691 | Not Yet Recruiting
| Myelodysplastic Syndromes | September 2015 | H. Lee Moffitt Cancer Center And Research Institute|Incyte Corporation | 2 | CHEM-BIOL? |
| 2 | Title: Schizophrenia Imaging
| NCT01655472 | Not Yet Recruiting
| Foetal Differences Between Healthy And Schizophernic Parents | July 2014
| Tel-Aviv Sourasky Medical Center | IMAGE N |
|
| 3 | C11 AMT Positron Emission Tomography (PET) Imaging In Patients With Metastatic Invasive Breast Cancer
| NCT01302821 | Not Yet Recruiting
| Breast Cancer | April 2014 | H. Lee Moffitt Cancer Center And Research Institute|National Cancer Institute (NCI) | NA | BIOL DC AV-P53 MT RADIA |
| 4 | Sonographic Evaluation Of Visceral Fat After Bariatric Surgery | NCT01285791 | Not Yet Recruiting | Morbid Obesity | April 2012 | Hadassah Medical Organization | OBS | BIOL CELL |
| 5 | How Our Immune System Can Help Fight Cancer
| NCT01042847 | Not Yet Recruiting
| Ovarian Cancer | January 2011 | Winthrop University Hospita | EVAL NA | POLY. BIOL |
| 6 | Title: Study Of The Long-Term Effect Of Frequent Anti-VEGF Dosing On Retinal Function In Patients With Neovascular AMD
| NCT00533689 | Not Yet Recruiting
| Electrophysiology | 2013 NA | Tel-Aviv Sourasky Medical Center | NA EYE | BIOL |
| 7
| Microbial Surveillance In Children Hospitalized For Cardiovascular Surgery
| NCT00426894 | Not Yet Recruiting
| Cardiac Surgery|Perioperative Prophylaxis | 2013 NA | Hadassah Medical Organization | OBS
|
|
| 8 | Study Of Chemotherapy In Combination With IDO Inhibitor In Metastatic Breast Cancer
| NCT01792050 | Not Recruitinbut Active G | Metastatic Breast Cancer | January 2015 | Newlink Genetics Corporation
| 2 | CHEM |
| 9 | A Dose-Escalation Study In Subjects With Advanced Malignancies | NCT01195311 | Not BUT Active Recruiting
| Advanced Malignancies | November 2012 | Incyte Corporation | 1 | CHEM DOSE |
| SP | Title: Mesalamine To Reduce T Cell Activation In HIV Infection
| NCT01090102 | Enrolling By Invitation
| HIV Infections|Sexually Transmitted Diseases|Immune System Diseases|Lentivirus Infections|Acquired Immunodeficiency Syndrome
| January 2013 | UC, San Francisco|California HIV/AIDS Research Program|Salix Pharmaceuticals | 4 | CHEM
|
| 1 | Study Of Indoleamine 2,3-Dioxygenase Activity, Serum Levels Of Cytokines, BDNF, BH4 And | NCT00919295 | Completed | Fibromyalgia Syndrome | October 2011 | Mahidol University|University Of Texas|University Of Wuerzburg | 2 | CHEM. |
| 2 | Diagnosis Of Posttraumatic Stress Disorder Following Primary Rhegmatogenous Retinal Detachment
| NCT01233908 | Completed | Stress Disorders, Post-Traumatic|Retinal Detachment | September 2010 | Sheba Medical Center | OBS EYE | BIOL |
| 3 | Comparison Of DCT, ORA And GAT In Eyes After Penetrating Keratoplasty
| NCT00834782 | Completed | Corneal Transplantation
| December 2009 | Sheba Medical Center | 4 |
|
| 4 | Disturbances Of Kynurenine Pathway Of Trytophan Metabolism In Schizophrenia: A Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) Study
| NCT00573300 | Completed | Schizophrenia | May 2009
| North Suffolk Mental Health Association | OBSV. | BIOL |
| 5 | Effect Of Biological Therapy On Biomarkers In Patients With Untreated Hepatitis C, Metastatic Melanoma, Or Crohn Disease
| NCT00897312 | Completed | Melanoma | August 2008 | Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) | OBSV. | BIOL-CHEM
|
| 6 | A Prospective Comparative Study Of Induction Of Labor With A Cervical Ripening Double Balloon Vs Foley Catheter
| NCT00501033 | Completed | Induction Of Labor|Cesarean|Endometritis | February 2008 | Western Galilee Hospital-Nahariya | NA | DEVICE |
| 7 | Tryptophan, Serotonin And Kynurenine In Septic Shock
| NCT00684736 | Completed | Shock, Septic | April 2007 | Central Hospital, Versailles | OBS | KYN |
| 8 | Imatinib Mesylate In Treating Patients With Metastatic Breast Cancer
| NCT00045188 | Completed | Male Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer | July 2004 | National Cancer Institute (NCI) | 2 | CHEM |
| 9 | IDO Peptid Vaccination For Stage III-IV Non Small-Cell Lung Cancer Patients.
| NCT01219348 | Completed | NSCLC|Lung Cancer | NA | IDO Peptide Vaccinantio | 1
|
|
| 10 | Indoleamine 2,3-Dioxygenase (IDO) Activity In Patients With Chronic Lymphocytic Leukemia (CLL) | NCT01397916
| Completed | CLL | NA | Tampere University Hospital
| NA |
|
| 11 | Tryptophan Metabolism In Kidney Disease
| NCT00758537 | Completed | Chronic Kidney Disease
| NA | Charite University, Berlin, Germany | OBS | BIOL TRP LEVELS |
| 12 | Observational To Investigate The Efficacy Of CRESTOR 5mg In Reaching LDL-C Target Goals In Patients Who Are At High Risk For A Cardiovascular Event
| NCT00347217 | Completed
| Hypercholesteremia Cardiovascular | NA | Astrazeneca | 4 | CHEM |
| 13 | The Association Between Delivery Method And Maternal Rehospitalization
| NCT00501501 | Completed | Hospitalization | NA | Western Galilee Hospital-Nahariya | OBS | BIOL |
| 14 | Uterine Flora During Elective And Urgent Cesarean Sections
| NCT00500019 | Completed | Endometritis | NA | Western Galilee Hospital-Nahariya
| OBS | BIOL |
| 15 | Title: Pilot, Proof-Of-Concept Study Of Sublingual Tizanidine In Children With Chronic Traumatic Brain Injury (TBI) | NCT00287157 | Completed | Traumatic Brain Injury
| NA | Teva GTC | 1 B | CHEM |
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