Posted On: 07/24/2013 10:58:21 PM
Post# of 72440
I think it will cover a majority of the autoimmune diseases specifically rheumatoid arthritis. I also believe it will cover multiple cancers. They have found overexpression of interleukin 20 in RA, cervical cancer, prostate cancer and likely many others that I have yet to read the research on.
If you look over the data the IL-20 was decreased substantially more with prurisol than methotrexate which is standard of care. Methotrexate is used as first line for multiple autoimmune disorders and is a mild chemotherapy drug.
What I have also found in my reading is that human and mice IL-20 are both composed of 174 or 176 amino acids (going from memory here) and are 76% percent identical.
P21 is also a biomarker that can be used to measure the activity of IL-20 inhibitors
If you look over the data the IL-20 was decreased substantially more with prurisol than methotrexate which is standard of care. Methotrexate is used as first line for multiple autoimmune disorders and is a mild chemotherapy drug.
What I have also found in my reading is that human and mice IL-20 are both composed of 174 or 176 amino acids (going from memory here) and are 76% percent identical.
P21 is also a biomarker that can be used to measure the activity of IL-20 inhibitors
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