"Where will the Roche's and the Mercs and the Glaxo's of the world be when these Biotechs annihilate existing technology? The above companies are , most assuredly,"Once in a lifetime"companies.

When these diseases are conquered by these companies (which is happening as we speak),what is left of "Big Pharma"?"

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Some big pharma will be thriving.  Look at SNY.  Not only is it buying hot, biopharmas like Genzyme, but it is acting as a Joint Venture partner with a lot of young small pharma companies.  SNY is a perfect example of how a big pharma company is morphing with the times and not dependent on just one tactic.  A company like CTIX, if the products work, will be bought out plain and simple.