100mg/kg created a slight improvement over the control group, but that was a single dose. At 200mg and 2 doses the tumor delay was almost to the end of the normal Nude Mouse life-cycle. I can't find it now, but I recall a communication from Menon where he talked about early testing and how 50mg 3 times had a small positive but inconclusive response, but when they upped to 200mg twice they had some subjects with full remission. 100mg (300mg/m2 human conversion) single dose is where the needle first moved conclusively .

We are still talking mice and not humans. Though Nude Mouse xenografts correlate with human results for many tumor types better than any other species or hybrid, they do not correlate with human results for the majority of cancers. We wait and see.