I like it when a scientist gets rowdy and speculates wildly. I actually believe that cohorts #5-6 will indeed hold the keys to P21 expression and that the side effects will be tolerable. My WAG for this is October 21, 2013. And yes seel, you are both fun and good at this.

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p21 expression will be measured consistently in all patients of cohorts 5 and 6. There will be only manageable side effects at cohort 5-6 doses, allowing for conclusion that future trials will start at dose that activates. Company will pr this activation. Hungry Pfizer will move out of the wings they've been waiting in and offer one of the most lucrative partnership deals we have ever witnessed. Buy-out will not occur - because Leo and Dr. M. have already told Pfizer that that is not goal for them at this time. Sp will spike to 26.00 on p21 news.