Seel,  at the rate of dose escalation just received from Leo and posted by Big K., would you say that even though the trial may continue til the end of the year to reach MTD most of the risk will be over by the end of summer (say the end of Sept) as we should be in/finished cohort 6 and  should Kevetrin still be working strong  with safety still OK the rest of the year is just icing on the cake to reach MTD?