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The new research, though, highlights much smaller and more dangerous shapes: α-synuclein oligomers. These tiny structures appear to puncture nerve cell membranes with microscopic holes.

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α-synuclein oligomers damaging the nerve cell membrane would increase intracellular calcium (CA2+) this additional burden on top of the intracellular CA2+ due to CCR5 would enhance mitochondrial destruction leading to nerve cell death. Leronlimab decreases intracellular CA2+.