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Posted On: 10/02/2025 11:28:20 AM
Post# of 157642
For what it's worth, ChatGPT did state:
4. CCR5 positivity by IHC
This is trickier. Data is sparse, but studies suggest ~50–60% of CRC tumors express CCR5 at detectable levels, though "positivity" by trial IHC cutoffs might be closer to 30–40%.
I didn't paste all of it's basis for conclusions although I can if it is something you'd like to see. But let's say it's off by 100% which by your calculation would mean a patient pool of 224,000. That's still a very small patient pool when we're only operating in 6 clinics over 4 states (that was updated today by the way if no one has mentioned it, looks like we added Nebraska and Pennsylvania). I don't know how many clinics there are in the country that see these kinds of patients but I can't imagine any of them are flooding with patients that fit our criteria.
4. CCR5 positivity by IHC
This is trickier. Data is sparse, but studies suggest ~50–60% of CRC tumors express CCR5 at detectable levels, though "positivity" by trial IHC cutoffs might be closer to 30–40%.
I didn't paste all of it's basis for conclusions although I can if it is something you'd like to see. But let's say it's off by 100% which by your calculation would mean a patient pool of 224,000. That's still a very small patient pool when we're only operating in 6 clinics over 4 states (that was updated today by the way if no one has mentioned it, looks like we added Nebraska and Pennsylvania). I don't know how many clinics there are in the country that see these kinds of patients but I can't imagine any of them are flooding with patients that fit our criteria.
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