(Total Views: 278)
Posted On: 10/01/2025 5:21:40 PM
Post# of 157645
"... but 350 mg dose is inadequate for covering CCR5 or efficacy...."
Dose escalation studies were done and higher doses are used in a variety of fashions. Your point is well taken, but a study is about comparing SOC to LL, and we have to show an efficacy escalation, let me say, for irrefutable trial data.
525mg seems a sweet spot, 700mg works best for RO but comes with a bit of diarrhea. It'll be nice when the CRC trial patients begin to receive 700mg hopefully soon. Recruitment should go much quicker then, and with on boarding new sites. IMHO
Dose escalation studies were done and higher doses are used in a variety of fashions. Your point is well taken, but a study is about comparing SOC to LL, and we have to show an efficacy escalation, let me say, for irrefutable trial data.
525mg seems a sweet spot, 700mg works best for RO but comes with a bit of diarrhea. It'll be nice when the CRC trial patients begin to receive 700mg hopefully soon. Recruitment should go much quicker then, and with on boarding new sites. IMHO
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