(Total Views: 348)
Posted On: 10/01/2025 4:02:35 PM
Post# of 157631
Re: Evil Rabbit #157465
Evil quoted the newsletter:
Actually, keep reading. Same paragraph as you cited:
So if 15/17 in the 525 mg category had increased PD-L1 expression, and 16/21 of all patients had increased PD-L1, expression, only 1 out of 4 in the 350 mg arm showed a significant increase in PD-L1 expression. 25% versus 88% in the 525 and 700 group.
350 mg isn't sugar water, but it isn't enough. Why would we want to give up 63% of any group of patients?
This is only regarding the PD-L1 expression. Ohm would know to what degree the 350 mg dose can help with macrophages, traveling cancer cells, etc.
Quote:
16/21 (76%) of patients showed a significant increase in PD-L1 expression on CTCs within 30-90 days after starting leronlimab, regardless of dose.
Actually, keep reading. Same paragraph as you cited:
Quote:
Even more remarkably, this shift from “cold” to “hot” occurred in 15/17 (88%) patients who received weekly leronlimab doses of 525 mg or higher.
So if 15/17 in the 525 mg category had increased PD-L1 expression, and 16/21 of all patients had increased PD-L1, expression, only 1 out of 4 in the 350 mg arm showed a significant increase in PD-L1 expression. 25% versus 88% in the 525 and 700 group.
350 mg isn't sugar water, but it isn't enough. Why would we want to give up 63% of any group of patients?
This is only regarding the PD-L1 expression. Ohm would know to what degree the 350 mg dose can help with macrophages, traveling cancer cells, etc.
(18)
(0)
