This is very unlike the Covid trial where patients were desperate to avoid intubation and death but when Remdesivir was pronounced “trending toward significance” by Fauci it sucked up all the treatment oxygen. With mss CRC patients are also desperate to avoid death…that is a get your affairs in order diagnosis. it’s an open lane on the treatment highway beyond standard of care, which is not moving the needle much. You have to remind yourself there are stringent inclusion/exclusion criteria for any patient to be inducted. Some patients may want the drug but don’t pass the inclusion exclusion criteria filters. There is also the ramp up of each trial site, physicians and trial nurses have to be alert to potential qualifying patients. Often IT is invoked to screen for potential trial participants. At the end of the day this is not a huge stretch for the doctor or patient. A consent has to be signed…would you sign it with that diagnosis? Forget what you know about the drug. If you are told…based on current research data it could seriously move the clinical needle and there is no known serious safety signal…are you signing? I am…this one is easy. Liability is not an issue for the physician…that is what the consent is for. If I were the doctor injecting bleach I would be reticent even with a signed consent…but our ace in the hole here is the safety record! Can Cytodyn do more to push the process? Perhaps…if I we’re Jay I would be pinging Dr Weinberg…he is the PI and the general trying to move things forward. We might get a lot of traction when the high volume clinic comes on line.