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Posted On: 09/25/2025 1:36:49 PM
Post# of 157259
thanks mgk...I'm not clear on what relates to what in the chart--I was looking specifically at the 1 year survival rate mentioned in the Pestell study and trying to see how it compared to trodelvy or keytruda (SOC) alone:
Survival outcomes:
Of the patients (median age, 48.5 years (32-83; N=28), prior lines of therapy in the metastatic setting (median=2), visceral metastases (64% (N=18)), of which (N=
had brain metastases, and non-visceral metastases (36% (N=10)), ∼18% of heavily pretreated mTNBC patients are currently alive after median >60 months. (1 year survival 35.7%; 2 year survival 21.4%; 3 and 4 year survival 17.9%).
So from your chart,
Median Overall Survival (OS)
(Keytruda) 23.0 months (PD-L1 CPS ≥10) vs. 16.1 months (chemo alone)
(Trodelvy) 11.8 months vs. 6.9 months (chemo alone)
What number is the apples-to-apples comparison to the 23.0 and 11.8 -- is there a pure Median OS in Pestell's abstract? Is it the >60 months?? That would be astounding but I want to make sure they're the same parameters. That's why I latched onto the 1 year survival rate, to try to find a straightforward point of comparison.
(I apologize for my blurryheadedness-- I took stats in grad school, even got an A, but that was decades ago and not in medicine!)
Survival outcomes:
Of the patients (median age, 48.5 years (32-83; N=28), prior lines of therapy in the metastatic setting (median=2), visceral metastases (64% (N=18)), of which (N=
had brain metastases, and non-visceral metastases (36% (N=10)), ∼18% of heavily pretreated mTNBC patients are currently alive after median >60 months. (1 year survival 35.7%; 2 year survival 21.4%; 3 and 4 year survival 17.9%). So from your chart,
Median Overall Survival (OS)
(Keytruda) 23.0 months (PD-L1 CPS ≥10) vs. 16.1 months (chemo alone)
(Trodelvy) 11.8 months vs. 6.9 months (chemo alone)
What number is the apples-to-apples comparison to the 23.0 and 11.8 -- is there a pure Median OS in Pestell's abstract? Is it the >60 months?? That would be astounding but I want to make sure they're the same parameters. That's why I latched onto the 1 year survival rate, to try to find a straightforward point of comparison.
(I apologize for my blurryheadedness-- I took stats in grad school, even got an A, but that was decades ago and not in medicine!)
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