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Posted On: 09/17/2025 12:07:55 AM
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???? New paper on CCR5 and MS, published Sept 10, 2025 in *Science Translational Medicine*:
Researchers showed that oligodendroglial precursor cells (OPCs) can amplify immune damage in MS by releasing the chemokine CCL4, which signals through CCR5. In a mouse model of MS, blocking CCR5 with the FDA-approved drug maraviroc significantly reduced immune cell infiltration, protected against demyelination, and slowed disease progression. This provides direct preclinical evidence that CCR5 antagonism could be protective in MS.
Full text (author-accepted manuscript):
https://pure.manchester.ac.uk/ws/files/362994...MS_STM.pdf
Citation: Wang Q, Huang T, Zheng Z, Su Y, Wu Z, Zeng C, et al. *Oligodendroglial precursor cells modulate immune response and early demyelination in a murine model of multiple sclerosis.* Sci Transl Med. 2025;17(792):eadn9980.
#CCR5 #MS #Maraviroc #Neuroinflammation #ScienceTranslationalMedicine
Researchers showed that oligodendroglial precursor cells (OPCs) can amplify immune damage in MS by releasing the chemokine CCL4, which signals through CCR5. In a mouse model of MS, blocking CCR5 with the FDA-approved drug maraviroc significantly reduced immune cell infiltration, protected against demyelination, and slowed disease progression. This provides direct preclinical evidence that CCR5 antagonism could be protective in MS.
Full text (author-accepted manuscript):
https://pure.manchester.ac.uk/ws/files/362994...MS_STM.pdf
Citation: Wang Q, Huang T, Zheng Z, Su Y, Wu Z, Zeng C, et al. *Oligodendroglial precursor cells modulate immune response and early demyelination in a murine model of multiple sclerosis.* Sci Transl Med. 2025;17(792):eadn9980.
#CCR5 #MS #Maraviroc #Neuroinflammation #ScienceTranslationalMedicine
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