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& Rogex broke down those that were in the post.....

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So how is it that Tumor survives within the body? Because Tumors have learned how to convince the Immune System that it is self. How does it do that? Through the expression of PD-L1 on its cell surface. Tumors which express PD-L1 on their cell surfaces are considered "Hot" Tumors. Through this expression of PD-L1 on their cell surface, Hot Tumors are able to convince the Immune System that they are self. If the Immune System considers the Hot Tumor Cells as self, then the Immune System passes over them and onto the next cell. Each and every Hot Tumor cell which communicates PD-L1, passes the check point test as self and therefore is not killed on the spot check.

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A mistaken impression I've seen here several times. Tumors are considered hot because they have a high immune response in other words a very high levels of M1 killer macrophages and natural killer T-cells. PD-L1 doesn't exist in cold tumors because PD-L1 is a response to a high level of killer macrophages and NKT cells. PD-L1 may be considered a marker of a hot tumor but only because the killer macrophages induce PD-L1 proliferation.

Ideally a hot tumor would not upregulate PD-L1 which protects the tumor, but that's not how it works because the immune system is trying to balance out the over-representation of killer cells. When leronlimab increases the M1 macrophage phenotype it results in an increased level of PD-L1 which must be knocked down for the killer cells to do their work most effectively.