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Posted On: 08/19/2025 1:29:15 PM
Post# of 156156
Does LL positively impact enzyme SSAT?
https://scitechdaily.com/psoriasis-breakthrou...e-effects/
As the researchers’ analyses revealed, the enzyme SSAT plays a key role in the loss of function of Treg cells. SSAT is involved in the regulation of certain molecules (polyamines) that are important for the balance between anti-inflammatory and pro-inflammatory immune cells. If SSAT is produced in increased amounts in Treg cells, they lose their regulatory function and begin to produce pro-inflammatory messenger substances themselves. This fuels the excessive immune response typical of psoriasis.
Targeted interruption of the inflammatory cycle
With the key role of SSAT in the inflammatory process, the researchers have simultaneously discovered a new starting point for therapy: In a mouse model with psoriasis-like skin inflammation, it was shown that inhibiting SSAT can restore the regulatory function of Treg cells and break the cycle of inflammation.
https://scitechdaily.com/psoriasis-breakthrou...e-effects/
As the researchers’ analyses revealed, the enzyme SSAT plays a key role in the loss of function of Treg cells. SSAT is involved in the regulation of certain molecules (polyamines) that are important for the balance between anti-inflammatory and pro-inflammatory immune cells. If SSAT is produced in increased amounts in Treg cells, they lose their regulatory function and begin to produce pro-inflammatory messenger substances themselves. This fuels the excessive immune response typical of psoriasis.
Targeted interruption of the inflammatory cycle
With the key role of SSAT in the inflammatory process, the researchers have simultaneously discovered a new starting point for therapy: In a mouse model with psoriasis-like skin inflammation, it was shown that inhibiting SSAT can restore the regulatory function of Treg cells and break the cycle of inflammation.
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